FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078694420> ?p ?o ?g. }

• W2078694420 endingPage "1640" @default.
• W2078694420 startingPage "1633" @default.
• W2078694420 abstract "This study examines a new method for the remote loading of doxorubicin into liposomes. It was shown that doxorubicin can be loaded to a level of up to 98% into large unilamellar vesicles composed of egg phosphatidylcholine/cholesterol (7/3 mol/mol) with a transmembrane phosphate gradient. The different encapsulation efficiencies which were achieved with ammonium salts (citrate 100%, phosphate 98%, sulfate 95%, acetate 77%) were significantly higher as compared to the loading via sodium salts (citrate 54%, phosphate 52%, sulfate 44%, acetate 16%). Various factors, including pH-value, buffer capacity, solubility of doxorubicin in different salt solutions and base counter-flow, which likely has an influence on drug accumulation in the intraliposomal interior are taken into account. In contrast to other methods, the newly developed remote loading method exhibits a pH-dependent drug release property which may be effective in tumor tissues. At physiological pH-value doxorubicin is retained in the liposomes, whereas drug release is achieved by lowering the pH to 5.5 (approximately 25% release at 25 degrees C or 30% at 37 degrees C within two h). The DXR release of liposomes which were loaded via a sulfate gradient showed a maximum of 3% at pH 5.5." @default.
• W2078694420 created "2016-06-24" @default.
• W2078694420 creator A5002972085 @default.
• W2078694420 creator A5008310812 @default.
• W2078694420 creator A5009365499 @default.
• W2078694420 creator A5030421320 @default.
• W2078694420 creator A5052992414 @default.
• W2078694420 date "2006-10-01" @default.
• W2078694420 modified "2023-10-11" @default.
• W2078694420 title "Remote loading of doxorubicin into liposomes driven by a transmembrane phosphate gradient" @default.
• W2078694420 cites W1495785845 @default.
• W2078694420 cites W1503396222 @default.
• W2078694420 cites W1605936672 @default.
• W2078694420 cites W1784578127 @default.
• W2078694420 cites W1849296542 @default.
• W2078694420 cites W1968351069 @default.
• W2078694420 cites W1972048837 @default.
• W2078694420 cites W1985309426 @default.
• W2078694420 cites W1990634170 @default.
• W2078694420 cites W1991387984 @default.
• W2078694420 cites W2003552025 @default.
• W2078694420 cites W2005408885 @default.
• W2078694420 cites W2007281600 @default.
• W2078694420 cites W2008296541 @default.
• W2078694420 cites W2013308107 @default.
• W2078694420 cites W2013342651 @default.
• W2078694420 cites W2019806179 @default.
• W2078694420 cites W2028065774 @default.
• W2078694420 cites W2029782824 @default.
• W2078694420 cites W2036944284 @default.
• W2078694420 cites W2037501592 @default.
• W2078694420 cites W2037563014 @default.
• W2078694420 cites W2039350685 @default.
• W2078694420 cites W2039810405 @default.
• W2078694420 cites W2040547723 @default.
• W2078694420 cites W2040876516 @default.
• W2078694420 cites W2044423157 @default.
• W2078694420 cites W2045091888 @default.
• W2078694420 cites W2045230140 @default.
• W2078694420 cites W2047245377 @default.
• W2078694420 cites W2048781063 @default.
• W2078694420 cites W2049043423 @default.
• W2078694420 cites W2049589023 @default.
• W2078694420 cites W2053516011 @default.
• W2078694420 cites W2054192565 @default.
• W2078694420 cites W2055265722 @default.
• W2078694420 cites W2058958777 @default.
• W2078694420 cites W2068524399 @default.
• W2078694420 cites W2075078368 @default.
• W2078694420 cites W2080742616 @default.
• W2078694420 cites W2090390505 @default.
• W2078694420 cites W2091130738 @default.
• W2078694420 cites W2094906575 @default.
• W2078694420 cites W2101742864 @default.
• W2078694420 cites W2113103250 @default.
• W2078694420 cites W2128183109 @default.
• W2078694420 cites W2142985551 @default.
• W2078694420 cites W2146974131 @default.
• W2078694420 cites W2154438514 @default.
• W2078694420 cites W2166003952 @default.
• W2078694420 doi "https://doi.org/10.1016/j.bbamem.2006.05.028" @default.
• W2078694420 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16887094" @default.
• W2078694420 hasPublicationYear "2006" @default.
• W2078694420 type Work @default.
• W2078694420 sameAs 2078694420 @default.
• W2078694420 citedByCount "336" @default.
• W2078694420 countsByYear W20786944202012 @default.
• W2078694420 countsByYear W20786944202013 @default.
• W2078694420 countsByYear W20786944202014 @default.
• W2078694420 countsByYear W20786944202015 @default.
• W2078694420 countsByYear W20786944202016 @default.
• W2078694420 countsByYear W20786944202017 @default.
• W2078694420 countsByYear W20786944202018 @default.
• W2078694420 countsByYear W20786944202019 @default.
• W2078694420 countsByYear W20786944202020 @default.
• W2078694420 countsByYear W20786944202021 @default.
• W2078694420 countsByYear W20786944202022 @default.
• W2078694420 countsByYear W20786944202023 @default.
• W2078694420 crossrefType "journal-article" @default.
• W2078694420 hasAuthorship W2078694420A5002972085 @default.
• W2078694420 hasAuthorship W2078694420A5008310812 @default.
• W2078694420 hasAuthorship W2078694420A5009365499 @default.
• W2078694420 hasAuthorship W2078694420A5030421320 @default.
• W2078694420 hasAuthorship W2078694420A5052992414 @default.
• W2078694420 hasBestOaLocation W20786944201 @default.
• W2078694420 hasConcept C12554922 @default.
• W2078694420 hasConcept C130316041 @default.
• W2078694420 hasConcept C13965031 @default.
• W2078694420 hasConcept C141071460 @default.
• W2078694420 hasConcept C155574463 @default.
• W2078694420 hasConcept C178790620 @default.
• W2078694420 hasConcept C185154212 @default.
• W2078694420 hasConcept C185592680 @default.
• W2078694420 hasConcept C2776330855 @default.
• W2078694420 hasConcept C2776694085 @default.
• W2078694420 hasConcept C2777132085 @default.
• W2078694420 hasConcept C2778918659 @default.
• W2078694420 hasConcept C2780925461 @default.

• next