FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078694570> ?p ?o ?g. }

• W2078694570 endingPage "1527" @default.
• W2078694570 startingPage "1519" @default.
• W2078694570 abstract "In addition to industrial sources, benzene is present in the environment as a component of cigarette smoke and automobile emissions. Toxicity of benzene most likely results from oxidative metabolism of benzene to reactive products. However, susceptibility to these toxic effects may be related to a balance between activation (phase I) and detoxication (phase II) reactions. In the present study, we have estimated kinetic parameters of the two major detoxication reactions for benzene metabolites—phenol sulfation and hydroquinone glucuronidation—in liver subcellular fractions from 10 humans, and single samples from mice and rats. The extent of oxidative metabolism of benzene by these liver samples has been reported previously. Here, initial rates of phenol sulfation varied 3-fold (range 0.309–0.919 nmol/mg protein/min) among human samples. Measured rates were faster in rats (1.195 nmol/mg protein/min) than in mice (0.458 nmol/mg protein/min). Initial rates of hydroquinone glucuronidation by human samples also varied 3-fold (range 0.101–0.281 nmol/mg protein/min). Hydroquinone glucuronidation was more rapid by mouse microsomes (0.218 nmol/ mg protein/min) than by rat microsomes (0.077 nmol/mg protein/min). To integrate interindividual differences in various enzyme activities, a physiological compartmental model was developed that incorporates rates of both conjugation reactions and oxidation reactions. Model equations were solved for steady-state concentrations of phenol and hydroquinone attained in human, mouse and rat blood during continuous exposure to benzene (0.01 μM in blood). Among the 10 human subjects, steady-state concentrations of phenol varied 6-fold (range 0.38–2.17 nM) and steady-state concentrations of hydroquinone varied 5-fold (range 6.66–31.44 nM). Predicted steady-state concentrations of phenol were higher in mice compared with rats (2.28 and 0.83 nM respectively). Likewise, higher steady-state concentrations of hydroquinone were predicted in mice than in rats (42.44 and 17.99 nM respectively). Predicted steady-state concentrations of phenol and hydroquinone in mice were higher than predictions for the 10 human subjects, whereas predicted concentrations for rats fell among the human values. As such, our results underscore the importance of considering the balance between activation and detoxication reactions in the elimination of toxicants. Model simulations suggest that both phase I and phase II pathways influence the relative risk from exposure to benzene." @default.
• W2078694570 created "2016-06-24" @default.
• W2078694570 creator A5051939394 @default.
• W2078694570 creator A5056906170 @default.
• W2078694570 creator A5072806278 @default.
• W2078694570 date "1995-01-01" @default.
• W2078694570 modified "2023-09-27" @default.
• W2078694570 title "In vitro conjugation of benzene metabolites by human liver: potential influence of interindividual variability on benzene toxicity" @default.
• W2078694570 doi "https://doi.org/10.1093/carcin/16.7.1519" @default.
• W2078694570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7614685" @default.
• W2078694570 hasPublicationYear "1995" @default.
• W2078694570 type Work @default.
• W2078694570 sameAs 2078694570 @default.
• W2078694570 citedByCount "40" @default.
• W2078694570 countsByYear W20786945702012 @default.
• W2078694570 countsByYear W20786945702014 @default.
• W2078694570 countsByYear W20786945702021 @default.
• W2078694570 crossrefType "journal-article" @default.
• W2078694570 hasAuthorship W2078694570A5051939394 @default.
• W2078694570 hasAuthorship W2078694570A5056906170 @default.
• W2078694570 hasAuthorship W2078694570A5072806278 @default.
• W2078694570 hasConcept C114246631 @default.
• W2078694570 hasConcept C155138218 @default.
• W2078694570 hasConcept C178790620 @default.
• W2078694570 hasConcept C181199279 @default.
• W2078694570 hasConcept C185592680 @default.
• W2078694570 hasConcept C2777550763 @default.
• W2078694570 hasConcept C2777691172 @default.
• W2078694570 hasConcept C2779907587 @default.
• W2078694570 hasConcept C27881333 @default.
• W2078694570 hasConcept C29730261 @default.
• W2078694570 hasConcept C43617362 @default.
• W2078694570 hasConcept C55493867 @default.
• W2078694570 hasConcept C62231903 @default.
• W2078694570 hasConcept C87644729 @default.
• W2078694570 hasConceptScore W2078694570C114246631 @default.
• W2078694570 hasConceptScore W2078694570C155138218 @default.
• W2078694570 hasConceptScore W2078694570C178790620 @default.
• W2078694570 hasConceptScore W2078694570C181199279 @default.
• W2078694570 hasConceptScore W2078694570C185592680 @default.
• W2078694570 hasConceptScore W2078694570C2777550763 @default.
• W2078694570 hasConceptScore W2078694570C2777691172 @default.
• W2078694570 hasConceptScore W2078694570C2779907587 @default.
• W2078694570 hasConceptScore W2078694570C27881333 @default.
• W2078694570 hasConceptScore W2078694570C29730261 @default.
• W2078694570 hasConceptScore W2078694570C43617362 @default.
• W2078694570 hasConceptScore W2078694570C55493867 @default.
• W2078694570 hasConceptScore W2078694570C62231903 @default.
• W2078694570 hasConceptScore W2078694570C87644729 @default.
• W2078694570 hasIssue "7" @default.
• W2078694570 hasLocation W20786945701 @default.
• W2078694570 hasLocation W20786945702 @default.
• W2078694570 hasOpenAccess W2078694570 @default.
• W2078694570 hasPrimaryLocation W20786945701 @default.
• W2078694570 hasRelatedWork W1607804913 @default.
• W2078694570 hasRelatedWork W1979833417 @default.
• W2078694570 hasRelatedWork W1980214281 @default.
• W2078694570 hasRelatedWork W2078694570 @default.
• W2078694570 hasRelatedWork W2125512191 @default.
• W2078694570 hasRelatedWork W2133668097 @default.
• W2078694570 hasRelatedWork W2147593455 @default.
• W2078694570 hasRelatedWork W2772983166 @default.
• W2078694570 hasRelatedWork W2914923483 @default.
• W2078694570 hasRelatedWork W609726981 @default.
• W2078694570 hasVolume "16" @default.
• W2078694570 isParatext "false" @default.
• W2078694570 isRetracted "false" @default.
• W2078694570 magId "2078694570" @default.
• W2078694570 workType "article" @default.