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- W2078695562 endingPage "12" @default.
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- W2078695562 abstract "11β-Hydroxysteroid dehydrogenase isoform 1 (11β-HSD1) is a member of the alcohol short-chain family enzyme, and catalyzes the interconversion between active glucocorticoid cortisol (in human) and inactive cortisone. The redox ratio of NADP+/NADPH determines its direction with NADPH favoring its reductase activity and NADP+ favoring its oxidase activity. In many tissues such as the liver and lung, 11β-HSD1 behaves primarily as a reductase because of the intracellular enzyme coupling with hexose-6-phosphate dehydrogenase, which uses the NADP+ as cofactor to supply NADPH driving 11β-HSD1 to function as a reductase. 11β-HSD1 catalyzes the metabolism of 7- or 11-keto steroids as well as many toxins and drugs. Some steroids, drugs and toxins are metabolically activated. The present review discusses the steroid, drug and toxin metabolism by 11β-HSD1." @default.
- W2078695562 created "2016-06-24" @default.
- W2078695562 creator A5023834243 @default.
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- W2078695562 creator A5080086185 @default.
- W2078695562 creator A5091243949 @default.
- W2078695562 creator A5091330490 @default.
- W2078695562 date "2012-02-01" @default.
- W2078695562 modified "2023-09-26" @default.
- W2078695562 title "The metabolism of steroids, toxins and drugs by 11β-hydroxysteroid dehydrogenase 1" @default.
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