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• W2078697242 abstract "Despite overwhelming evidence that transcriptional activation by TP53 is critical for its tumor suppressive activity, the mechanisms by which TP53 engages the genome in the context of chromatin to activate transcription are not well understood. Using a compendium of novel and existing genome-wide data sets, we examined the relationship between TP53 binding and the dynamics of the local chromatin environment. Our analysis revealed three distinct categories of TP53 binding events that differ based on the dynamics of the local chromatin environment. The first class of TP53 binding events occurs near transcriptional start sites (TSS) and is defined by previously characterized promoter-associated chromatin modifications. The second class comprises a large cohort of preestablished, promoter-distal enhancer elements that demonstrates dynamic histone acetylation and transcription upon TP53 binding. The third class of TP53 binding sites is devoid of classic chromatin modifications and, remarkably, fall within regions of inaccessible chromatin, suggesting that TP53 has intrinsic pioneer factor activity and binds within structurally inaccessible regions of chromatin. Intriguingly, these inaccessible TP53 binding sites feature several enhancer-like properties in cell types within the epithelial lineage, indicating that TP53 binding events include a group of “proto-enhancers” that become active enhancers given the appropriate cellular context. These data indicate that TP53, along with TP63, may act as pioneer factors to specify epithelial enhancers. Further, these findings suggest that rather than following a global cell-type invariant stress response program, TP53 may tune its response based on the lineage-specific epigenomic landscape." @default.
• W2078697242 created "2016-06-24" @default.
• W2078697242 creator A5031423026 @default.
• W2078697242 creator A5060890139 @default.
• W2078697242 creator A5081437292 @default.
• W2078697242 creator A5086901195 @default.
• W2078697242 date "2014-11-12" @default.
• W2078697242 modified "2023-10-17" @default.
• W2078697242 title "TP53 engagement with the genome occurs in distinct local chromatin environments via pioneer factor activity" @default.
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• W2078697242 doi "https://doi.org/10.1101/gr.181883.114" @default.
• W2078697242 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4315292" @default.
• W2078697242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25391375" @default.
• W2078697242 hasPublicationYear "2014" @default.
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