FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078698002> ?p ?o ?g. }

• W2078698002 endingPage "127" @default.
• W2078698002 startingPage "119" @default.
• W2078698002 abstract "The ATP-gated K(+) channel openers - diazoxide, levcromakalim and morphine - enhance K(+) efflux by opening ATP-gated K(+) channels, thereby inducing cell hyperpolarization. Hyperpolarization decreases intracellular Ca(2+) levels, which leads to a decrease in neurotransmitter release contributing to the antinociceptive effects of the drugs. Previous findings implicate the release of endogenous opioids as the mediator of the antinociceptive effects of ATP-gated K(+) channel openers. Diazoxide and levcromakalim, administered intracerebroventricularly (i.c.v.), produced dose-dependent antinociception as determined by the tail-flick method ¿ED(50) 44 microg/mouse [95% confidence limits (CLs) from 28 to 68 microg/mouse] for diazoxide¿. Glyburide (10 microg/mouse), an ATP-gated K(+) channel antagonist, attenuated the effects of diazoxide, levcromakalim and morphine. Diazoxide- and levcromakalim-induced antinociception were both antagonized by CTOP (D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr amide), a mu-opioid receptor selective antagonist, and ICI 174,864 (N, N-diallyl-Tyr-Aib-Aib-Phe-Leu), a delta-opioid receptor antagonist, but were differentially attenuated by the kappa-opioid receptor antagonist, nor-Binaltorphimine. Combinations of inactive doses of the K(+) channel openers and opioid receptor agonists produced significant antinociceptive enhancement. Diazoxide (2 microg/mouse) shifted morphine's dose-response curve 47-fold, while levcromakalim (0.1 microg/mouse) shifted the curve 27-fold. The dose-response curve of kappa-opioid receptor agonist U50,488H (trans-(+/-)-3, 4 Dichloro-N-[2-(1-pyrrolidinyl)-cyclohexyl] benzeneacetamide methane sulfonate) was shifted 106-fold by diazoxide in a parallel manner, while levcromakalim administration increased the potency of U50,488H by 15-fold. Diazoxide shifted the dose-response curve of the delta-opioid receptor agonist, DPDPE [(D-Pen(2,5))-enkephalin], leftward in a non-parallel manner, while DPDPE was 6-fold more potent when combined with levcromakalim. We hypothesize that endogenous opioids mediate ATP-gated K(+) channel opener-induced antinociception and enhancement of opioids." @default.
• W2078698002 created "2016-06-24" @default.
• W2078698002 creator A5023651064 @default.
• W2078698002 creator A5073216406 @default.
• W2078698002 date "1999-12-01" @default.
• W2078698002 modified "2023-10-14" @default.
• W2078698002 title "ATP-gated K+ channel openers enhance opioid antinociception: indirect evidence for the release of endogenous opioid peptides" @default.
• W2078698002 cites W1582263310 @default.
• W2078698002 cites W1975909527 @default.
• W2078698002 cites W1985108182 @default.
• W2078698002 cites W1990640328 @default.
• W2078698002 cites W1992823328 @default.
• W2078698002 cites W2000857078 @default.
• W2078698002 cites W2004401380 @default.
• W2078698002 cites W2007452911 @default.
• W2078698002 cites W2012119611 @default.
• W2078698002 cites W2015414166 @default.
• W2078698002 cites W2017576562 @default.
• W2078698002 cites W2018414719 @default.
• W2078698002 cites W2018696433 @default.
• W2078698002 cites W2027752934 @default.
• W2078698002 cites W2028816743 @default.
• W2078698002 cites W2030533584 @default.
• W2078698002 cites W2033232160 @default.
• W2078698002 cites W2037388211 @default.
• W2078698002 cites W2040965816 @default.
• W2078698002 cites W2043899013 @default.
• W2078698002 cites W2071789342 @default.
• W2078698002 cites W2071998745 @default.
• W2078698002 cites W2083584165 @default.
• W2078698002 cites W2161531330 @default.
• W2078698002 cites W2165498557 @default.
• W2078698002 cites W2172913083 @default.
• W2078698002 cites W42425883 @default.
• W2078698002 doi "https://doi.org/10.1016/s0014-2999(99)00618-4" @default.
• W2078698002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10607867" @default.
• W2078698002 hasPublicationYear "1999" @default.
• W2078698002 type Work @default.
• W2078698002 sameAs 2078698002 @default.
• W2078698002 citedByCount "26" @default.
• W2078698002 countsByYear W20786980022012 @default.
• W2078698002 countsByYear W20786980022013 @default.
• W2078698002 countsByYear W20786980022015 @default.
• W2078698002 countsByYear W20786980022016 @default.
• W2078698002 countsByYear W20786980022021 @default.
• W2078698002 countsByYear W20786980022023 @default.
• W2078698002 crossrefType "journal-article" @default.
• W2078698002 hasAuthorship W2078698002A5023651064 @default.
• W2078698002 hasAuthorship W2078698002A5073216406 @default.
• W2078698002 hasConcept C126322002 @default.
• W2078698002 hasConcept C131453863 @default.
• W2078698002 hasConcept C134018914 @default.
• W2078698002 hasConcept C170493617 @default.
• W2078698002 hasConcept C184389661 @default.
• W2078698002 hasConcept C185592680 @default.
• W2078698002 hasConcept C2775962371 @default.
• W2078698002 hasConcept C2776885963 @default.
• W2078698002 hasConcept C2777953665 @default.
• W2078698002 hasConcept C2778750930 @default.
• W2078698002 hasConcept C2778938600 @default.
• W2078698002 hasConcept C2779306644 @default.
• W2078698002 hasConcept C2779872217 @default.
• W2078698002 hasConcept C2779886867 @default.
• W2078698002 hasConcept C2780561956 @default.
• W2078698002 hasConcept C2781063702 @default.
• W2078698002 hasConcept C55493867 @default.
• W2078698002 hasConcept C66974803 @default.
• W2078698002 hasConcept C71240020 @default.
• W2078698002 hasConcept C71924100 @default.
• W2078698002 hasConcept C83743174 @default.
• W2078698002 hasConcept C98274493 @default.
• W2078698002 hasConceptScore W2078698002C126322002 @default.
• W2078698002 hasConceptScore W2078698002C131453863 @default.
• W2078698002 hasConceptScore W2078698002C134018914 @default.
• W2078698002 hasConceptScore W2078698002C170493617 @default.
• W2078698002 hasConceptScore W2078698002C184389661 @default.
• W2078698002 hasConceptScore W2078698002C185592680 @default.
• W2078698002 hasConceptScore W2078698002C2775962371 @default.
• W2078698002 hasConceptScore W2078698002C2776885963 @default.
• W2078698002 hasConceptScore W2078698002C2777953665 @default.
• W2078698002 hasConceptScore W2078698002C2778750930 @default.
• W2078698002 hasConceptScore W2078698002C2778938600 @default.
• W2078698002 hasConceptScore W2078698002C2779306644 @default.
• W2078698002 hasConceptScore W2078698002C2779872217 @default.
• W2078698002 hasConceptScore W2078698002C2779886867 @default.
• W2078698002 hasConceptScore W2078698002C2780561956 @default.
• W2078698002 hasConceptScore W2078698002C2781063702 @default.
• W2078698002 hasConceptScore W2078698002C55493867 @default.
• W2078698002 hasConceptScore W2078698002C66974803 @default.
• W2078698002 hasConceptScore W2078698002C71240020 @default.
• W2078698002 hasConceptScore W2078698002C71924100 @default.
• W2078698002 hasConceptScore W2078698002C83743174 @default.
• W2078698002 hasConceptScore W2078698002C98274493 @default.
• W2078698002 hasIssue "2-3" @default.
• W2078698002 hasLocation W20786980021 @default.
• W2078698002 hasLocation W20786980022 @default.
• W2078698002 hasOpenAccess W2078698002 @default.
• W2078698002 hasPrimaryLocation W20786980021 @default.

• next