FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078700613> ?p ?o ?g. }

• W2078700613 endingPage "70" @default.
• W2078700613 startingPage "64" @default.
• W2078700613 abstract "Little controlled drug administration data are available to aid in the interpretation of gamma-hydroxybutyric acid (GHB) distribution in conventional and nonconventional fluids and the potential correlation between the pharmacokinetics of GHB and drug effects. Single oral sodium GHB doses of 50 mg/kg were administered to five volunteers. Plasma, oral fluid, urine, and sweat were analyzed for GHB by gas chromatography-mass spectrometry. GHB stability in plasma was studied at different storage temperatures. Subjective effects were measured using a set of 13 different visual analog scales. Mean peak GHB plasma concentrations at 30 minutes were 83.1 μg/mL. After the absorption phase, concentrations declined to mean values of 0.9 μg/mL at 6 hours. GHB was found in oral fluid at peak value concentrations equivalent to one third to one fourth of those found in plasma. The oral fluid-to-plasma ratio varied two fold in the 1- to 6-hour time range but always was lower than unit. The mean half-life (t1/2) of GHB was approximately 0.7 hour in plasma and approximately 1.2 hours in oral fluid. GHB urinary excretion is less than 2% of the dose administered. GHB was also detected in sweat at low concentrations. GHB showed a mixed sedative-stimulant pattern with subjective effects peaking between 1 and 1.5 hours after drug administration and lasting for 2 hours. Oral fluid and sweat appeared not to be suitable biologic matrices for monitoring GHB consumption. GHB -mediated subjective effects are related to GHB plasma concentrations." @default.
• W2078700613 created "2016-06-24" @default.
• W2078700613 creator A5007695195 @default.
• W2078700613 creator A5013809289 @default.
• W2078700613 creator A5020006084 @default.
• W2078700613 creator A5033539160 @default.
• W2078700613 creator A5038117672 @default.
• W2078700613 creator A5050142892 @default.
• W2078700613 creator A5053212432 @default.
• W2078700613 creator A5087857627 @default.
• W2078700613 date "2007-02-01" @default.
• W2078700613 modified "2023-09-29" @default.
• W2078700613 title "Disposition of Gamma-Hydroxybutyric Acid in Conventional and Nonconventional Biologic Fluids After Single Drug Administration: Issues in Methodology and Drug Monitoring" @default.
• W2078700613 cites W1937806137 @default.
• W2078700613 cites W1959371971 @default.
• W2078700613 cites W1964528013 @default.
• W2078700613 cites W1973987848 @default.
• W2078700613 cites W1983282994 @default.
• W2078700613 cites W1988391948 @default.
• W2078700613 cites W1995062262 @default.
• W2078700613 cites W2000488780 @default.
• W2078700613 cites W2004805804 @default.
• W2078700613 cites W2011845889 @default.
• W2078700613 cites W2025987186 @default.
• W2078700613 cites W2057656968 @default.
• W2078700613 cites W2065451165 @default.
• W2078700613 cites W2069198409 @default.
• W2078700613 cites W2072863696 @default.
• W2078700613 cites W2074453710 @default.
• W2078700613 cites W2086729630 @default.
• W2078700613 cites W2088225142 @default.
• W2078700613 cites W2094913169 @default.
• W2078700613 cites W2116251941 @default.
• W2078700613 cites W2116326543 @default.
• W2078700613 cites W2124192083 @default.
• W2078700613 cites W2125100413 @default.
• W2078700613 cites W2125233562 @default.
• W2078700613 cites W2137107830 @default.
• W2078700613 cites W2140458643 @default.
• W2078700613 cites W2147135138 @default.
• W2078700613 cites W2162745202 @default.
• W2078700613 cites W2164382943 @default.
• W2078700613 cites W2164953838 @default.
• W2078700613 cites W2168371115 @default.
• W2078700613 cites W2169620727 @default.
• W2078700613 cites W2171142600 @default.
• W2078700613 cites W2333738191 @default.
• W2078700613 doi "https://doi.org/10.1097/ftd.0b013e3180307e5e" @default.
• W2078700613 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17304152" @default.
• W2078700613 hasPublicationYear "2007" @default.
• W2078700613 type Work @default.
• W2078700613 sameAs 2078700613 @default.
• W2078700613 citedByCount "60" @default.
• W2078700613 countsByYear W20787006132012 @default.
• W2078700613 countsByYear W20787006132013 @default.
• W2078700613 countsByYear W20787006132014 @default.
• W2078700613 countsByYear W20787006132015 @default.
• W2078700613 countsByYear W20787006132016 @default.
• W2078700613 countsByYear W20787006132017 @default.
• W2078700613 countsByYear W20787006132018 @default.
• W2078700613 countsByYear W20787006132019 @default.
• W2078700613 countsByYear W20787006132020 @default.
• W2078700613 countsByYear W20787006132021 @default.
• W2078700613 countsByYear W20787006132022 @default.
• W2078700613 countsByYear W20787006132023 @default.
• W2078700613 crossrefType "journal-article" @default.
• W2078700613 hasAuthorship W2078700613A5007695195 @default.
• W2078700613 hasAuthorship W2078700613A5013809289 @default.
• W2078700613 hasAuthorship W2078700613A5020006084 @default.
• W2078700613 hasAuthorship W2078700613A5033539160 @default.
• W2078700613 hasAuthorship W2078700613A5038117672 @default.
• W2078700613 hasAuthorship W2078700613A5050142892 @default.
• W2078700613 hasAuthorship W2078700613A5053212432 @default.
• W2078700613 hasAuthorship W2078700613A5087857627 @default.
• W2078700613 hasConcept C112705442 @default.
• W2078700613 hasConcept C121332964 @default.
• W2078700613 hasConcept C125287762 @default.
• W2078700613 hasConcept C126322002 @default.
• W2078700613 hasConcept C185592680 @default.
• W2078700613 hasConcept C24890656 @default.
• W2078700613 hasConcept C2777056448 @default.
• W2078700613 hasConcept C2777602617 @default.
• W2078700613 hasConcept C2780026642 @default.
• W2078700613 hasConcept C2780035454 @default.
• W2078700613 hasConcept C43617362 @default.
• W2078700613 hasConcept C63398376 @default.
• W2078700613 hasConcept C71924100 @default.
• W2078700613 hasConcept C98274493 @default.
• W2078700613 hasConceptScore W2078700613C112705442 @default.
• W2078700613 hasConceptScore W2078700613C121332964 @default.
• W2078700613 hasConceptScore W2078700613C125287762 @default.
• W2078700613 hasConceptScore W2078700613C126322002 @default.
• W2078700613 hasConceptScore W2078700613C185592680 @default.
• W2078700613 hasConceptScore W2078700613C24890656 @default.
• W2078700613 hasConceptScore W2078700613C2777056448 @default.
• W2078700613 hasConceptScore W2078700613C2777602617 @default.
• W2078700613 hasConceptScore W2078700613C2780026642 @default.
• W2078700613 hasConceptScore W2078700613C2780035454 @default.

• next