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• W2078702456 abstract "In this work, the equilibrium shape and dynamics of a primary cilium under flow are investigated by using both theoretical modeling and experiment. The cilium is modeled as an elastic beam that may undergo large deflection due to the hydrodynamic load. Equilibrium results show that the anchoring effects of the basal body on the cilium axoneme behave as a nonlinear rotational spring. Details of the rotational spring are elucidated by coupling the elastic beam with an elastic shell. We further study the dynamics of cilium under shear flow with the cilium base angle determined from the nonlinear rotational spring, and obtain good agreement in cilium bending and relaxing dynamics when comparing between modeling and experimental results. These results potentially shed light on the physics underlying the mechanosensitive ion channel transport through the ciliary membrane." @default.
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• W2078702456 date "2012-08-01" @default.
• W2078702456 modified "2023-10-16" @default.
• W2078702456 title "Dynamics of the Primary Cilium in Shear Flow" @default.
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• W2078702456 doi "https://doi.org/10.1016/j.bpj.2012.07.009" @default.
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