Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078702704> ?p ?o ?g. }
- W2078702704 endingPage "e105331" @default.
- W2078702704 startingPage "e105331" @default.
- W2078702704 abstract "Ovarian cancer presents therapeutic challenges due to its typically late detection, aggressive metastasis, and therapeutic resistance. The transcription factor Krüppel-like factor 4 (KLF4) has been implicated in human cancers as a tumor suppressor or oncogene, although its role depends greatly on the cellular context. The role of KLF4 in ovarian cancer has not been elucidated in mechanistic detail. In this study, we investigated the role of KLF4 in ovarian cancer cells by transducing the ovarian cancer cell lines SKOV3 and OVCAR3 with a doxycycline-inducible KLF4 lentiviral vector. Overexpression of KLF4 reduced cell proliferation, migration, and invasion. The epithelial cell marker gene E-cadherin was significantly upregulated, whereas the mesenchymal cell marker genes vimentin, twist1 and snail2 (slug) were downregulated in both KLF4-expressing SKOV3 and OVCAR3 cells. KLF4 inhibited the transforming growth factor β (TGFβ)-induced epithelial to mesenchymal transition (EMT) in ovarian cancer cells. Taken together, our data demonstrate that KLF4 functions as a tumor suppressor gene in ovarian cancer cells by inhibiting TGFβ-induced EMT." @default.
- W2078702704 created "2016-06-24" @default.
- W2078702704 creator A5001969147 @default.
- W2078702704 creator A5002561503 @default.
- W2078702704 creator A5024774099 @default.
- W2078702704 creator A5025924166 @default.
- W2078702704 creator A5031540280 @default.
- W2078702704 creator A5036560647 @default.
- W2078702704 creator A5047305591 @default.
- W2078702704 creator A5065485631 @default.
- W2078702704 creator A5068097623 @default.
- W2078702704 creator A5068949602 @default.
- W2078702704 creator A5076715598 @default.
- W2078702704 creator A5083303279 @default.
- W2078702704 creator A5090610227 @default.
- W2078702704 date "2014-08-19" @default.
- W2078702704 modified "2023-10-12" @default.
- W2078702704 title "Doxycycline Inducible Kruppel-Like Factor 4 Lentiviral Vector Mediates Mesenchymal to Epithelial Transition in Ovarian Cancer Cells" @default.
- W2078702704 cites W1226810604 @default.
- W2078702704 cites W1521023654 @default.
- W2078702704 cites W1523544792 @default.
- W2078702704 cites W1775301645 @default.
- W2078702704 cites W1967903148 @default.
- W2078702704 cites W1971365179 @default.
- W2078702704 cites W1974012180 @default.
- W2078702704 cites W1984734909 @default.
- W2078702704 cites W1986931242 @default.
- W2078702704 cites W1994775779 @default.
- W2078702704 cites W2001293278 @default.
- W2078702704 cites W2008202172 @default.
- W2078702704 cites W2009270241 @default.
- W2078702704 cites W2015200386 @default.
- W2078702704 cites W2016080237 @default.
- W2078702704 cites W2019723293 @default.
- W2078702704 cites W2022205031 @default.
- W2078702704 cites W2022639530 @default.
- W2078702704 cites W2026324708 @default.
- W2078702704 cites W2030115828 @default.
- W2078702704 cites W2044064179 @default.
- W2078702704 cites W2044224053 @default.
- W2078702704 cites W2049565394 @default.
- W2078702704 cites W2060654974 @default.
- W2078702704 cites W2061747533 @default.
- W2078702704 cites W2065009934 @default.
- W2078702704 cites W2066866337 @default.
- W2078702704 cites W2084349416 @default.
- W2078702704 cites W2093324515 @default.
- W2078702704 cites W2094831008 @default.
- W2078702704 cites W2104600384 @default.
- W2078702704 cites W2125713917 @default.
- W2078702704 cites W2138065115 @default.
- W2078702704 cites W2147807172 @default.
- W2078702704 cites W2150059780 @default.
- W2078702704 cites W2168259018 @default.
- W2078702704 cites W2170367835 @default.
- W2078702704 doi "https://doi.org/10.1371/journal.pone.0105331" @default.
- W2078702704 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4138168" @default.
- W2078702704 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25137052" @default.
- W2078702704 hasPublicationYear "2014" @default.
- W2078702704 type Work @default.
- W2078702704 sameAs 2078702704 @default.
- W2078702704 citedByCount "43" @default.
- W2078702704 countsByYear W20787027042015 @default.
- W2078702704 countsByYear W20787027042016 @default.
- W2078702704 countsByYear W20787027042017 @default.
- W2078702704 countsByYear W20787027042018 @default.
- W2078702704 countsByYear W20787027042019 @default.
- W2078702704 countsByYear W20787027042020 @default.
- W2078702704 countsByYear W20787027042021 @default.
- W2078702704 countsByYear W20787027042022 @default.
- W2078702704 countsByYear W20787027042023 @default.
- W2078702704 crossrefType "journal-article" @default.
- W2078702704 hasAuthorship W2078702704A5001969147 @default.
- W2078702704 hasAuthorship W2078702704A5002561503 @default.
- W2078702704 hasAuthorship W2078702704A5024774099 @default.
- W2078702704 hasAuthorship W2078702704A5025924166 @default.
- W2078702704 hasAuthorship W2078702704A5031540280 @default.
- W2078702704 hasAuthorship W2078702704A5036560647 @default.
- W2078702704 hasAuthorship W2078702704A5047305591 @default.
- W2078702704 hasAuthorship W2078702704A5065485631 @default.
- W2078702704 hasAuthorship W2078702704A5068097623 @default.
- W2078702704 hasAuthorship W2078702704A5068949602 @default.
- W2078702704 hasAuthorship W2078702704A5076715598 @default.
- W2078702704 hasAuthorship W2078702704A5083303279 @default.
- W2078702704 hasAuthorship W2078702704A5090610227 @default.
- W2078702704 hasBestOaLocation W20787027041 @default.
- W2078702704 hasConcept C104317684 @default.
- W2078702704 hasConcept C121608353 @default.
- W2078702704 hasConcept C147447768 @default.
- W2078702704 hasConcept C203014093 @default.
- W2078702704 hasConcept C204232928 @default.
- W2078702704 hasConcept C2777933648 @default.
- W2078702704 hasConcept C2778265714 @default.
- W2078702704 hasConcept C2779013556 @default.
- W2078702704 hasConcept C2780427987 @default.
- W2078702704 hasConcept C2781018059 @default.
- W2078702704 hasConcept C29537977 @default.
- W2078702704 hasConcept C502942594 @default.