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• W2078702908 startingPage "1886" @default.
• W2078702908 abstract "Recombinant Adenoviral vectors represent one of the best gene transfer platforms due to their ability to efficiently transduce a wide range of quiescent and proliferating cell types from various tissues and species. The activation of an adaptive immune response against the transduced cells is one of the major drawbacks of first generation Adenovirus vectors and has been overcome by the latest generation of recombinant Adenovirus, the Helper-Dependent Adenoviral (HDAd) vectors. HDAds have innovative features including the complete absence of viral coding sequences and the ability to mediate high level transgene expression with negligible chronic toxicity. This review summarizes the many aspects of HDAd biology and structure with a major focus on in vivo gene therapy application and with an emphasis on the unsolved issues that these vectors still presents toward clinical application." @default.
• W2078702908 created "2016-06-24" @default.
• W2078702908 creator A5035274699 @default.
• W2078702908 creator A5035714683 @default.
• W2078702908 date "2010-09-03" @default.
• W2078702908 modified "2023-10-02" @default.
• W2078702908 title "Gene Therapy with Helper-Dependent Adenoviral Vectors: Current Advances and Future Perspectives" @default.
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