FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078704638> ?p ?o ?g. }

• W2078704638 endingPage "87" @default.
• W2078704638 startingPage "78" @default.
• W2078704638 abstract "In mouse thymic lymphoma 3SB cells bearing wild type p53, ionizing radiation (IR) and UV light are potent triggers of caspase-3-dependent apoptosis. Although cytochrome c was released from mitochondria as expected, caspase-9 activation was not observed in UV-exposed cells. Laser scanning confocal microscopy analysis showed that caspase-9 is localized in an unusual punctuated pattern in UV-induced apoptotic cells. In agreement with differences in the status of caspase-9 activation between IR and UV, subcellular protein fractionation experiments showed that pro-apoptotic apoptosis protease-activating factor 1 (Apaf-1), normally a part of the apoptosome assembled in response to the release of cytochrome c from mitochondria, and B-cell lymphoma extra long (Bcl-xL), an inhibitor of the change in mitochondrial membrane permeability, were redistributed by the IR-exposure but not by the UV-exposure. Instead of the sequestration of the capase-9/apoptosome activation in UV-induced apoptotic cells, the extrinsic apoptotic signaling generated by caspase-8 activation and consequent activation of B-cell lymphoma extra long (Bid) to release cytochrome c from mitochondria was observed. Thus, the post-mitochondrial apoptotic pathway downstream of cytochrome c release cannot operate the apoptosome function in UV-induced apoptosis in thymic 3SB cells. The intracellular redistribution and sequestration of apoptosis-related proteins upon mitochondrion-based apoptotic signaling was identified as a novel cellular mechanism to respond to DNA damage in an agent type-specific manner. This finding suggests that the kind of the critical ultimate apoptosis-inducing DNA lesion complex form resulting from the agent-specific DNA damage responses is important to determine which of apoptosis signals would be activated." @default.
• W2078704638 created "2016-06-24" @default.
• W2078704638 creator A5006975848 @default.
• W2078704638 creator A5034977332 @default.
• W2078704638 creator A5072836217 @default.
• W2078704638 date "2010-06-01" @default.
• W2078704638 modified "2023-10-18" @default.
• W2078704638 title "Differential regulation of caspase-9 by ionizing radiation- and UV-induced apoptotic pathways in thymic cells" @default.
• W2078704638 cites W1506642042 @default.
• W2078704638 cites W1976961832 @default.
• W2078704638 cites W1979039759 @default.
• W2078704638 cites W1979664185 @default.
• W2078704638 cites W1986190434 @default.
• W2078704638 cites W1988756673 @default.
• W2078704638 cites W1993300108 @default.
• W2078704638 cites W1994936482 @default.
• W2078704638 cites W1995463051 @default.
• W2078704638 cites W1999057673 @default.
• W2078704638 cites W2007795814 @default.
• W2078704638 cites W2007939817 @default.
• W2078704638 cites W2011359957 @default.
• W2078704638 cites W2011980989 @default.
• W2078704638 cites W2012173926 @default.
• W2078704638 cites W2023851153 @default.
• W2078704638 cites W2033191623 @default.
• W2078704638 cites W2034901222 @default.
• W2078704638 cites W2043651078 @default.
• W2078704638 cites W2054681435 @default.
• W2078704638 cites W2055349083 @default.
• W2078704638 cites W2059028566 @default.
• W2078704638 cites W2061497413 @default.
• W2078704638 cites W2068240610 @default.
• W2078704638 cites W2070692423 @default.
• W2078704638 cites W2070968982 @default.
• W2078704638 cites W2073028327 @default.
• W2078704638 cites W2074615071 @default.
• W2078704638 cites W2078581194 @default.
• W2078704638 cites W2079831187 @default.
• W2078704638 cites W2088956884 @default.
• W2078704638 cites W2093279813 @default.
• W2078704638 cites W2094696997 @default.
• W2078704638 cites W2111650534 @default.
• W2078704638 cites W2113999599 @default.
• W2078704638 cites W2119683782 @default.
• W2078704638 cites W2120473562 @default.
• W2078704638 cites W2124221273 @default.
• W2078704638 cites W2139386752 @default.
• W2078704638 cites W2144472027 @default.
• W2078704638 cites W2156257249 @default.
• W2078704638 cites W2289050278 @default.
• W2078704638 cites W2315629023 @default.
• W2078704638 cites W2318774711 @default.
• W2078704638 cites W2330673460 @default.
• W2078704638 cites W4243872276 @default.
• W2078704638 doi "https://doi.org/10.1016/j.mrfmmm.2010.03.012" @default.
• W2078704638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20346366" @default.
• W2078704638 hasPublicationYear "2010" @default.
• W2078704638 type Work @default.
• W2078704638 sameAs 2078704638 @default.
• W2078704638 citedByCount "7" @default.
• W2078704638 countsByYear W20787046382013 @default.
• W2078704638 countsByYear W20787046382014 @default.
• W2078704638 countsByYear W20787046382015 @default.
• W2078704638 countsByYear W20787046382016 @default.
• W2078704638 countsByYear W20787046382023 @default.
• W2078704638 crossrefType "journal-article" @default.
• W2078704638 hasAuthorship W2078704638A5006975848 @default.
• W2078704638 hasAuthorship W2078704638A5034977332 @default.
• W2078704638 hasAuthorship W2078704638A5072836217 @default.
• W2078704638 hasConcept C153911025 @default.
• W2078704638 hasConcept C163421366 @default.
• W2078704638 hasConcept C173358068 @default.
• W2078704638 hasConcept C190283241 @default.
• W2078704638 hasConcept C193349765 @default.
• W2078704638 hasConcept C28859421 @default.
• W2078704638 hasConcept C29311851 @default.
• W2078704638 hasConcept C31573885 @default.
• W2078704638 hasConcept C55493867 @default.
• W2078704638 hasConcept C86803240 @default.
• W2078704638 hasConcept C95444343 @default.
• W2078704638 hasConcept C98424977 @default.
• W2078704638 hasConceptScore W2078704638C153911025 @default.
• W2078704638 hasConceptScore W2078704638C163421366 @default.
• W2078704638 hasConceptScore W2078704638C173358068 @default.
• W2078704638 hasConceptScore W2078704638C190283241 @default.
• W2078704638 hasConceptScore W2078704638C193349765 @default.
• W2078704638 hasConceptScore W2078704638C28859421 @default.
• W2078704638 hasConceptScore W2078704638C29311851 @default.
• W2078704638 hasConceptScore W2078704638C31573885 @default.
• W2078704638 hasConceptScore W2078704638C55493867 @default.
• W2078704638 hasConceptScore W2078704638C86803240 @default.
• W2078704638 hasConceptScore W2078704638C95444343 @default.
• W2078704638 hasConceptScore W2078704638C98424977 @default.
• W2078704638 hasIssue "1-2" @default.
• W2078704638 hasLocation W20787046381 @default.
• W2078704638 hasLocation W20787046382 @default.
• W2078704638 hasOpenAccess W2078704638 @default.
• W2078704638 hasPrimaryLocation W20787046381 @default.

• next