FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078704741> ?p ?o ?g. }

• W2078704741 endingPage "166" @default.
• W2078704741 startingPage "159" @default.
• W2078704741 abstract "An acute and potentially life-threatening complication associated with the recreational use of the 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) is hyperthermia. In the present study, Sprague-Dawley rats treated with MDMA (40 mg/kg s.c.) responded with a significant increase (maximal at 1 h) in rectal and skeletal muscle temperatures that lasted for at least 3 h post-treatment. Hypophysectomized (HYPO) and thyroparathyroidectomized (TX) animals treated with MDMA (40 mg/kg s.c.) did not become hyperthermic and in fact displayed a significant hypothermia. The HYPO and TX animals were also resistant to the serotonergic neurotoxic effects of MDMA assessed by serotonin measurements 4 to 7 days later in the striatum and hippocampus. MDMA (40 mg/kg s.c.) induced a significant increase in thyroxine levels 1 h post-treatment. Thyroid hormone replacement in TX animals returned the hyperthermic response seen after MDMA. Prazosin, an alpha(1)-antagonist (0.2 mg/kg i.p.), administered 30 min before MDMA significantly attenuated the MDMA-induced increase in rectal temperature, but had no effect on skeletal muscle temperature. Cyanopindolol, a beta(3)-antagonist (4 mg/kg s.c.), administered 30 min before MDMA (40 mg/kg s.c.) significantly attenuated the increase in skeletal muscle temperature, but had no effect on the rise in rectal temperature. The combination of prazosin and cyanopindolol resulted in an abolishment of MDMA-induced hyperthermia. The mechanisms of thermogenesis induced by MDMA seem to result from an interaction between the hypothalamic-pituitary-thyroid axis and the sympathetic nervous system, wherein mechanisms leading to core and skeletal muscle hyperthermia after MDMA exposure seem to be differentially regulated by alpha(1)- and beta(3)-adrenergic receptors." @default.
• W2078704741 created "2016-06-24" @default.
• W2078704741 creator A5023437507 @default.
• W2078704741 creator A5025982747 @default.
• W2078704741 creator A5040531815 @default.
• W2078704741 creator A5049619754 @default.
• W2078704741 date "2003-01-21" @default.
• W2078704741 modified "2023-10-12" @default.
• W2078704741 title "Hypothalamic-Pituitary-Thyroid Axis and Sympathetic Nervous System Involvement in Hyperthermia Induced by 3,4-Methylenedioxymethamphetamine (Ecstasy)" @default.
• W2078704741 cites W1672199487 @default.
• W2078704741 cites W1886546158 @default.
• W2078704741 cites W1960526592 @default.
• W2078704741 cites W1964847294 @default.
• W2078704741 cites W1966305781 @default.
• W2078704741 cites W1970290995 @default.
• W2078704741 cites W1970902020 @default.
• W2078704741 cites W1979950401 @default.
• W2078704741 cites W1999489764 @default.
• W2078704741 cites W2002861559 @default.
• W2078704741 cites W2009275235 @default.
• W2078704741 cites W2019673219 @default.
• W2078704741 cites W2031713060 @default.
• W2078704741 cites W2036982675 @default.
• W2078704741 cites W2066023103 @default.
• W2078704741 cites W2069800617 @default.
• W2078704741 cites W2072436586 @default.
• W2078704741 cites W2074690643 @default.
• W2078704741 cites W2079218486 @default.
• W2078704741 cites W2083049504 @default.
• W2078704741 cites W2083385526 @default.
• W2078704741 cites W2087693218 @default.
• W2078704741 cites W2092618585 @default.
• W2078704741 cites W2092663898 @default.
• W2078704741 cites W2105455639 @default.
• W2078704741 cites W2118614496 @default.
• W2078704741 cites W2162391320 @default.
• W2078704741 cites W2166120388 @default.
• W2078704741 cites W2166469175 @default.
• W2078704741 cites W4245816985 @default.
• W2078704741 cites W4249000512 @default.
• W2078704741 doi "https://doi.org/10.1124/jpet.102.044982" @default.
• W2078704741 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12649364" @default.
• W2078704741 hasPublicationYear "2003" @default.
• W2078704741 type Work @default.
• W2078704741 sameAs 2078704741 @default.
• W2078704741 citedByCount "97" @default.
• W2078704741 countsByYear W20787047412012 @default.
• W2078704741 countsByYear W20787047412013 @default.
• W2078704741 countsByYear W20787047412014 @default.
• W2078704741 countsByYear W20787047412015 @default.
• W2078704741 countsByYear W20787047412016 @default.
• W2078704741 countsByYear W20787047412017 @default.
• W2078704741 countsByYear W20787047412018 @default.
• W2078704741 countsByYear W20787047412020 @default.
• W2078704741 countsByYear W20787047412021 @default.
• W2078704741 countsByYear W20787047412023 @default.
• W2078704741 crossrefType "journal-article" @default.
• W2078704741 hasAuthorship W2078704741A5023437507 @default.
• W2078704741 hasAuthorship W2078704741A5025982747 @default.
• W2078704741 hasAuthorship W2078704741A5040531815 @default.
• W2078704741 hasAuthorship W2078704741A5049619754 @default.
• W2078704741 hasConcept C100564792 @default.
• W2078704741 hasConcept C118552586 @default.
• W2078704741 hasConcept C126322002 @default.
• W2078704741 hasConcept C134018914 @default.
• W2078704741 hasConcept C170493617 @default.
• W2078704741 hasConcept C185592680 @default.
• W2078704741 hasConcept C2775864247 @default.
• W2078704741 hasConcept C2776885963 @default.
• W2078704741 hasConcept C2777390192 @default.
• W2078704741 hasConcept C2779488553 @default.
• W2078704741 hasConcept C2779949491 @default.
• W2078704741 hasConcept C2780648677 @default.
• W2078704741 hasConcept C2780876324 @default.
• W2078704741 hasConcept C37000724 @default.
• W2078704741 hasConcept C42219234 @default.
• W2078704741 hasConcept C71924100 @default.
• W2078704741 hasConcept C98274493 @default.
• W2078704741 hasConceptScore W2078704741C100564792 @default.
• W2078704741 hasConceptScore W2078704741C118552586 @default.
• W2078704741 hasConceptScore W2078704741C126322002 @default.
• W2078704741 hasConceptScore W2078704741C134018914 @default.
• W2078704741 hasConceptScore W2078704741C170493617 @default.
• W2078704741 hasConceptScore W2078704741C185592680 @default.
• W2078704741 hasConceptScore W2078704741C2775864247 @default.
• W2078704741 hasConceptScore W2078704741C2776885963 @default.
• W2078704741 hasConceptScore W2078704741C2777390192 @default.
• W2078704741 hasConceptScore W2078704741C2779488553 @default.
• W2078704741 hasConceptScore W2078704741C2779949491 @default.
• W2078704741 hasConceptScore W2078704741C2780648677 @default.
• W2078704741 hasConceptScore W2078704741C2780876324 @default.
• W2078704741 hasConceptScore W2078704741C37000724 @default.
• W2078704741 hasConceptScore W2078704741C42219234 @default.
• W2078704741 hasConceptScore W2078704741C71924100 @default.
• W2078704741 hasConceptScore W2078704741C98274493 @default.
• W2078704741 hasIssue "1" @default.
• W2078704741 hasLocation W20787047411 @default.
• W2078704741 hasLocation W20787047412 @default.

• next