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- W2078708149 abstract "Traditional laxatives are effective at relieving the symptoms of constipation but data for their role in long-term chronic constipation are limited. PEG is the only traditional laxative to have been studied in trials lasting longer than 16 weeks. Traditional laxatives are not tolerated by all patients, either because of side effects or dosage regimen, and are not effective in all patients with chronic constipation. For such patients, alternative approaches are needed. Two promising drug classes are the chloride channel activators such as lubiprostone, and new serotonergic enterokinetic agents such as the selective 5-HT4 agonist prucalopride." @default.
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- W2078708149 date "2009-05-01" @default.
- W2078708149 modified "2023-09-23" @default.
- W2078708149 title "Treatment of Chronic Constipation: Current Pharmacologic Approaches and Future Directions" @default.
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- W2078708149 doi "https://doi.org/10.1016/j.cgh.2008.12.006" @default.
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