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• W2078713085 abstract "Cellular senescence was first reported in human fibroblasts as a state of stable in vitro growth arrest following extended culture. Since that initial observation, a variety of other phenotypic characteristics have been shown to co-associate with irreversible cell cycle exit in senescent fibroblasts. These include (1) a pro-inflammatory secretory response, (2) the up-regulation of immune ligands, (3) altered responses to apoptotic stimuli and (4) promiscuous gene expression (stochastic activation of genes possibly as a result of chromatin remodeling). Many features associated with senescent fibroblasts appear to promote conversion to an immunogenic phenotype that facilitates self-elimination by the immune system. Pro-inflammatory cytokines can attract and activate immune cells, the presentation of membrane bound immune ligands allows for specific recognition and promiscuous gene expression may function to generate an array of tissue restricted proteins that could subsequently be processed into peptides for presentation via MHC molecules. However, the phenotypes of senescent cells from different tissues and species are often assumed to be broadly similar to those seen in senescent human fibroblasts, but the data show a more complex picture in which the growth arrest mechanism, tissue of origin and species can all radically modulate this basic pattern. Furthermore, well-established triggers of cell senescence are often associated with a DNA damage response (DDR), but this may not be a universal feature of senescent cells. As such, we discuss the role of DNA damage in regulating an immunogenic response in senescent cells, in addition to discussing less established “atypical” senescent states that may occur independent of DNA damage." @default.
• W2078713085 created "2016-06-24" @default.
• W2078713085 creator A5027190196 @default.
• W2078713085 creator A5053780924 @default.
• W2078713085 date "2015-03-20" @default.
• W2078713085 modified "2023-10-06" @default.
• W2078713085 title "Cellular senescence: from growth arrest to immunogenic conversion" @default.
• W2078713085 cites W1536298439 @default.
• W2078713085 cites W1539873584 @default.
• W2078713085 cites W1553367038 @default.
• W2078713085 cites W1563936556 @default.
• W2078713085 cites W159681246 @default.
• W2078713085 cites W1632349675 @default.
• W2078713085 cites W1663526709 @default.
• W2078713085 cites W1853088825 @default.
• W2078713085 cites W1884535615 @default.
• W2078713085 cites W1948543785 @default.
• W2078713085 cites W1964295923 @default.
• W2078713085 cites W1964440144 @default.
• W2078713085 cites W1964951140 @default.
• W2078713085 cites W1965354428 @default.
• W2078713085 cites W1966453709 @default.
• W2078713085 cites W1966859474 @default.
• W2078713085 cites W1969250416 @default.
• W2078713085 cites W1969464492 @default.
• W2078713085 cites W1969503475 @default.
• W2078713085 cites W1970472050 @default.
• W2078713085 cites W1975774056 @default.
• W2078713085 cites W1976635482 @default.
• W2078713085 cites W1977362098 @default.
• W2078713085 cites W1977385137 @default.
• W2078713085 cites W1978256629 @default.
• W2078713085 cites W1978720331 @default.
• W2078713085 cites W1980523527 @default.
• W2078713085 cites W1982395176 @default.
• W2078713085 cites W1983052307 @default.
• W2078713085 cites W1983820182 @default.
• W2078713085 cites W1984051946 @default.
• W2078713085 cites W1986654313 @default.
• W2078713085 cites W1987908689 @default.
• W2078713085 cites W1993571663 @default.
• W2078713085 cites W1994714027 @default.
• W2078713085 cites W1997136478 @default.
• W2078713085 cites W1997893106 @default.
• W2078713085 cites W2001294667 @default.
• W2078713085 cites W2001815700 @default.
• W2078713085 cites W2002254994 @default.
• W2078713085 cites W2002303094 @default.
• W2078713085 cites W2002838864 @default.
• W2078713085 cites W2002863353 @default.
• W2078713085 cites W2003646458 @default.
• W2078713085 cites W2003982140 @default.
• W2078713085 cites W2004273407 @default.
• W2078713085 cites W2004314923 @default.
• W2078713085 cites W2006498791 @default.
• W2078713085 cites W2009166249 @default.
• W2078713085 cites W2010417927 @default.
• W2078713085 cites W2011705183 @default.
• W2078713085 cites W2013287222 @default.
• W2078713085 cites W2013781424 @default.
• W2078713085 cites W2015347505 @default.
• W2078713085 cites W2015665286 @default.
• W2078713085 cites W2018476521 @default.
• W2078713085 cites W2018686812 @default.
• W2078713085 cites W2019276374 @default.
• W2078713085 cites W2022861507 @default.
• W2078713085 cites W2023015403 @default.
• W2078713085 cites W2023283620 @default.
• W2078713085 cites W2026890342 @default.
• W2078713085 cites W2027249470 @default.
• W2078713085 cites W2027700437 @default.
• W2078713085 cites W2027931017 @default.
• W2078713085 cites W2028169108 @default.
• W2078713085 cites W2028253315 @default.
• W2078713085 cites W2028941546 @default.
• W2078713085 cites W2029744253 @default.
• W2078713085 cites W2030120780 @default.
• W2078713085 cites W2032352567 @default.
• W2078713085 cites W2033221504 @default.
• W2078713085 cites W2033748513 @default.
• W2078713085 cites W2036092325 @default.
• W2078713085 cites W2036676765 @default.
• W2078713085 cites W2038454445 @default.
• W2078713085 cites W2039677002 @default.
• W2078713085 cites W2041615416 @default.
• W2078713085 cites W2042000503 @default.
• W2078713085 cites W2042140414 @default.
• W2078713085 cites W2044341880 @default.
• W2078713085 cites W2045264627 @default.
• W2078713085 cites W2045269599 @default.
• W2078713085 cites W2047119143 @default.
• W2078713085 cites W2047330128 @default.
• W2078713085 cites W2051088438 @default.
• W2078713085 cites W2051781369 @default.
• W2078713085 cites W2052388837 @default.
• W2078713085 cites W2054161575 @default.
• W2078713085 cites W2058647415 @default.
• W2078713085 cites W2058664460 @default.
• W2078713085 cites W2059681268 @default.
• W2078713085 cites W2061765285 @default.

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