FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078714083> ?p ?o ?g. }

• W2078714083 endingPage "186" @default.
• W2078714083 startingPage "179" @default.
• W2078714083 abstract "Vasoconstrictor factors, like urotensin, angiotensin and catecholamines, activate Rho-dependent serine-threonine kinase (Rho-kinase) and inhibition of this pathway represents a novel therapy for cardiovascular diseases with hypertensive syndrome. The disbalance of relaxing endothelial nitric oxide (NO)-producing and vasoconstrictive pathways can be especially important in diseases where hypertension is accompanied by endothelial dysfunction that compromises NO generation. However, a recent study reported that the efficacy of the Rho-kinase inhibitor (R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)cyclohexanecarboxamide (Y27632) is dramatically attenuated upon removal of endothelium or inhibition of endothelial NO synthase (eNOS). This raises the question whether Rho-kinase inhibition could be an effective treatment in case of hypertension associated with endothelial dysfunction. The purpose of the present study was to determine whether the vasorelaxing effect of Rho-kinase inhibition is mediated through eNOS-dependent mechanisms. We show here that in the models of genetically reduced endothelial NO production (eNOS-/- mice and spontaneous hypertensive rats (SHR)) or in models of pharmacologically reduced endogenous NO production (N(omega)-nitro-L-arginine methyl ester (LNAME) treatment), Rho-kinase inhibition induced a strong vasodilation and reduction of blood pressure indicating independence of Rho-kinase pathway from eNOS. An additional important finding of our study is that Rho-kinase inhibitors induce a strong vasorelaxation and blood pressure reduction upon intravenous injection not only in hypertensive but in normotensive animals, as well. Inhibition of Rho-kinase represents a promising possibility to treat hypertension that is accompanied by endothelial dysfunction." @default.
• W2078714083 created "2016-06-24" @default.
• W2078714083 creator A5022121355 @default.
• W2078714083 creator A5036442263 @default.
• W2078714083 creator A5039473467 @default.
• W2078714083 creator A5047593064 @default.
• W2078714083 creator A5083811457 @default.
• W2078714083 date "2005-01-01" @default.
• W2078714083 modified "2023-09-23" @default.
• W2078714083 title "Inhibition of Rho-kinase stimulates nitric oxide-independent vasorelaxation" @default.
• W2078714083 cites W1597787921 @default.
• W2078714083 cites W1902300865 @default.
• W2078714083 cites W1972099640 @default.
• W2078714083 cites W1974364823 @default.
• W2078714083 cites W1978437761 @default.
• W2078714083 cites W1998856849 @default.
• W2078714083 cites W1999361409 @default.
• W2078714083 cites W2003011648 @default.
• W2078714083 cites W2027217536 @default.
• W2078714083 cites W2030081740 @default.
• W2078714083 cites W2052750950 @default.
• W2078714083 cites W2091193879 @default.
• W2078714083 cites W2102052376 @default.
• W2078714083 cites W2111833940 @default.
• W2078714083 cites W2114630275 @default.
• W2078714083 cites W2120978344 @default.
• W2078714083 cites W2121452261 @default.
• W2078714083 cites W2123349772 @default.
• W2078714083 cites W2131662040 @default.
• W2078714083 cites W2134080458 @default.
• W2078714083 cites W2141253144 @default.
• W2078714083 cites W2145708730 @default.
• W2078714083 cites W2147290899 @default.
• W2078714083 cites W2149194612 @default.
• W2078714083 cites W2153968612 @default.
• W2078714083 cites W2156588778 @default.
• W2078714083 cites W2159570527 @default.
• W2078714083 cites W2185099184 @default.
• W2078714083 cites W2323793886 @default.
• W2078714083 doi "https://doi.org/10.1016/j.ejphar.2004.11.047" @default.
• W2078714083 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15659308" @default.
• W2078714083 hasPublicationYear "2005" @default.
• W2078714083 type Work @default.
• W2078714083 sameAs 2078714083 @default.
• W2078714083 citedByCount "31" @default.
• W2078714083 countsByYear W20787140832012 @default.
• W2078714083 countsByYear W20787140832013 @default.
• W2078714083 countsByYear W20787140832014 @default.
• W2078714083 countsByYear W20787140832015 @default.
• W2078714083 countsByYear W20787140832016 @default.
• W2078714083 countsByYear W20787140832017 @default.
• W2078714083 countsByYear W20787140832018 @default.
• W2078714083 countsByYear W20787140832021 @default.
• W2078714083 countsByYear W20787140832022 @default.
• W2078714083 crossrefType "journal-article" @default.
• W2078714083 hasAuthorship W2078714083A5022121355 @default.
• W2078714083 hasAuthorship W2078714083A5036442263 @default.
• W2078714083 hasAuthorship W2078714083A5039473467 @default.
• W2078714083 hasAuthorship W2078714083A5047593064 @default.
• W2078714083 hasAuthorship W2078714083A5083811457 @default.
• W2078714083 hasConcept C120770815 @default.
• W2078714083 hasConcept C126322002 @default.
• W2078714083 hasConcept C134018914 @default.
• W2078714083 hasConcept C184235292 @default.
• W2078714083 hasConcept C185592680 @default.
• W2078714083 hasConcept C201800478 @default.
• W2078714083 hasConcept C2776992346 @default.
• W2078714083 hasConcept C2777622882 @default.
• W2078714083 hasConcept C2778326061 @default.
• W2078714083 hasConcept C2778609687 @default.
• W2078714083 hasConcept C2780972559 @default.
• W2078714083 hasConcept C2908929049 @default.
• W2078714083 hasConcept C519581460 @default.
• W2078714083 hasConcept C55493867 @default.
• W2078714083 hasConcept C71924100 @default.
• W2078714083 hasConcept C84393581 @default.
• W2078714083 hasConcept C97029542 @default.
• W2078714083 hasConcept C98274493 @default.
• W2078714083 hasConceptScore W2078714083C120770815 @default.
• W2078714083 hasConceptScore W2078714083C126322002 @default.
• W2078714083 hasConceptScore W2078714083C134018914 @default.
• W2078714083 hasConceptScore W2078714083C184235292 @default.
• W2078714083 hasConceptScore W2078714083C185592680 @default.
• W2078714083 hasConceptScore W2078714083C201800478 @default.
• W2078714083 hasConceptScore W2078714083C2776992346 @default.
• W2078714083 hasConceptScore W2078714083C2777622882 @default.
• W2078714083 hasConceptScore W2078714083C2778326061 @default.
• W2078714083 hasConceptScore W2078714083C2778609687 @default.
• W2078714083 hasConceptScore W2078714083C2780972559 @default.
• W2078714083 hasConceptScore W2078714083C2908929049 @default.
• W2078714083 hasConceptScore W2078714083C519581460 @default.
• W2078714083 hasConceptScore W2078714083C55493867 @default.
• W2078714083 hasConceptScore W2078714083C71924100 @default.
• W2078714083 hasConceptScore W2078714083C84393581 @default.
• W2078714083 hasConceptScore W2078714083C97029542 @default.
• W2078714083 hasConceptScore W2078714083C98274493 @default.
• W2078714083 hasIssue "1-3" @default.
• W2078714083 hasLocation W20787140831 @default.

• next