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• W2078726734 abstract "Human gC1qR/p33 is a multi-compartmental and multi-functional cellular protein expressed on a wide range of tissues and cell types including lymphocytes, endothelial cells, dendritic cells, and platelets. Although originally isolated as a receptor for C1q by virtue of its affinity (Kd=15–50 nM), and specificity for the globular heads of this molecule, a large body of evidence has now been accumulated which shows that in addition to C1q, gC1qR can serve as a receptor for diverse proinflammatory ligands including proteins of the plasma kinin-forming system, most notably high molecular weight kininogen (HK; Kd=9 nM). In addition, gC1qR has been reported to recognize and bind a number of functional antigens of viral and bacterial origin. It is its ability to interact with microbial antigens and its potential to serve as a cellular protein for bacterial attachment and/or entry that has been the focus of our laboratory in the past few years. On the surface of activated platelets, gC1qR has been shown to serve as a binding site for Staphylococcus aureus and this binding is mediated by protein A. Since the binding of S. aureus to platelets is postulated to play a major role in the pathogenesis of endocarditis, gC1qR may provide a suitable surface for the initial adhesion of the bacterium. Recent data also demonstrate that the exosporium of Bacillus cereus, a member of a genus of aerobic, Gram-positive, spore-forming rod-like bacilli, which includes the deadly Bacillus anthracis, contains a binding site for gC1qR. Therefore, by virtue of its ability to recognize plasma proteins such as C1q and HK, as well as bacterial and viral antigens, cell-surface gC1qR not only is able to generate proinflammatory byproducts from the complement and kinin/kallikrein systems, but also can be an efficient vehicle and platform for a plethora of pathogenic microorganisms." @default.
• W2078726734 created "2016-06-24" @default.
• W2078726734 creator A5012990589 @default.
• W2078726734 creator A5023783979 @default.
• W2078726734 date "2007-06-01" @default.
• W2078726734 modified "2023-10-17" @default.
• W2078726734 title "The contribution of gC1qR/p33 in infection and inflammation" @default.
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• W2078726734 doi "https://doi.org/10.1016/j.imbio.2006.11.011" @default.
• W2078726734 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2001281" @default.
• W2078726734 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17544818" @default.
• W2078726734 hasPublicationYear "2007" @default.
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