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- W2078731100 abstract "Dendrimers are well-defined (monodisperse) synthetic globular polymers with a range of interesting chemical and biological properties. Chemical properties include the presence of multiple accessible surface functional groups that can be used for coupling biologically relevant molecules and methods that allow for precise heterofunctionalization of surface groups. Biologically, dendrimers are highly biocompatible and have predictable biodistribution and cell membrane interacting characteristics determined by their size and surface charge. Dendrimers have optimal characteristics to fill the need for efficient immunostimulating compounds (adjuvants) that can increase the efficiency of vaccines, as dendrimers can provide molecularly defined multivalent scaffolds to produce highly defined conjugates with small molecule immunostimulators and/or antigens. The review gives an overview on the use of dendrimers as molecularly defined carriers/presenters of small antigens, including constructs that have built-in immunostimulatory (adjuvant) properties, and as stand-alone adjuvants that can be mixed with antigens to provide efficient vaccine formulations. These approaches allow the preparation of molecularly defined vaccines with highly predictable and specific properties and enable knowledge-based vaccine design substituting the traditional empirically based approaches for vaccine development and production." @default.
- W2078731100 created "2016-06-24" @default.
- W2078731100 creator A5043072336 @default.
- W2078731100 creator A5071167872 @default.
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- W2078731100 date "2009-11-04" @default.
- W2078731100 modified "2023-10-13" @default.
- W2078731100 title "Dendrimers for Vaccine and Immunostimulatory Uses. A Review" @default.
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- W2078731100 doi "https://doi.org/10.1021/bc900290d" @default.
- W2078731100 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19886668" @default.
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