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• W2078733356 abstract "Background Learning by conditioning is a key ability of animals and humans for acquiring novel behavior necessary for survival in a changing environment. Aberrant conditioning has been considered a crucial factor in the etiology and maintenance of panic disorder with agoraphobia (PD/A). Cognitive-behavioral therapy (CBT) is an effective treatment for PD/A. However, the neural mechanisms underlying the effects of CBT on conditioning processes in PD/A are unknown. Methods In a randomized, controlled, multicenter clinical trial in medication-free patients with PD/A who were treated with 12 sessions of manualized CBT, functional magnetic resonance imaging (fMRI) was used during fear conditioning before and after CBT. Quality-controlled fMRI data from 42 patients and 42 healthy subjects were obtained. Results After CBT, patients compared to control subjects revealed reduced activation for the conditioned response (CS+ > CS–) in the left inferior frontal gyrus (IFG). This activation reduction was correlated with reduction in agoraphobic symptoms from t1 to t2. Patients compared to control subjects also demonstrated increased connectivity between the IFG and regions of the “fear network” (amygdalae, insulae, anterior cingulate cortex) across time. Conclusions This study demonstrates the link between cerebral correlates of cognitive (IFG) and emotional (“fear network”) processing during symptom improvement across time in PD/A. Further research along this line has promising potential to support the development and further optimization of targeted treatments. Learning by conditioning is a key ability of animals and humans for acquiring novel behavior necessary for survival in a changing environment. Aberrant conditioning has been considered a crucial factor in the etiology and maintenance of panic disorder with agoraphobia (PD/A). Cognitive-behavioral therapy (CBT) is an effective treatment for PD/A. However, the neural mechanisms underlying the effects of CBT on conditioning processes in PD/A are unknown. In a randomized, controlled, multicenter clinical trial in medication-free patients with PD/A who were treated with 12 sessions of manualized CBT, functional magnetic resonance imaging (fMRI) was used during fear conditioning before and after CBT. Quality-controlled fMRI data from 42 patients and 42 healthy subjects were obtained. After CBT, patients compared to control subjects revealed reduced activation for the conditioned response (CS+ > CS–) in the left inferior frontal gyrus (IFG). This activation reduction was correlated with reduction in agoraphobic symptoms from t1 to t2. Patients compared to control subjects also demonstrated increased connectivity between the IFG and regions of the “fear network” (amygdalae, insulae, anterior cingulate cortex) across time. This study demonstrates the link between cerebral correlates of cognitive (IFG) and emotional (“fear network”) processing during symptom improvement across time in PD/A. Further research along this line has promising potential to support the development and further optimization of targeted treatments." @default.
• W2078733356 created "2016-06-24" @default.
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• W2078733356 date "2013-01-01" @default.
• W2078733356 modified "2023-10-16" @default.
• W2078733356 title "Effect of Cognitive-Behavioral Therapy on Neural Correlates of Fear Conditioning in Panic Disorder" @default.
• W2078733356 cites W1964698313 @default.
• W2078733356 cites W1965222801 @default.
• W2078733356 cites W1965788374 @default.
• W2078733356 cites W1967660841 @default.
• W2078733356 cites W1975345989 @default.
• W2078733356 cites W1982058506 @default.
• W2078733356 cites W1990137058 @default.
• W2078733356 cites W1995780552 @default.
• W2078733356 cites W1999807232 @default.
• W2078733356 cites W2005190428 @default.
• W2078733356 cites W2008245053 @default.
• W2078733356 cites W2008784431 @default.
• W2078733356 cites W2009470183 @default.
• W2078733356 cites W2011355679 @default.
• W2078733356 cites W2012254415 @default.
• W2078733356 cites W2016117011 @default.
• W2078733356 cites W2016521818 @default.
• W2078733356 cites W2028864037 @default.
• W2078733356 cites W2033866475 @default.
• W2078733356 cites W2035520183 @default.
• W2078733356 cites W2044634376 @default.
• W2078733356 cites W2046836290 @default.
• W2078733356 cites W2050618347 @default.
• W2078733356 cites W2052869567 @default.
• W2078733356 cites W2057988711 @default.
• W2078733356 cites W2058324327 @default.
• W2078733356 cites W2059217700 @default.
• W2078733356 cites W2064135174 @default.
• W2078733356 cites W2064896421 @default.
• W2078733356 cites W2065107893 @default.
• W2078733356 cites W2066027038 @default.
• W2078733356 cites W2074036774 @default.
• W2078733356 cites W2078515955 @default.
• W2078733356 cites W2082315793 @default.
• W2078733356 cites W2086146798 @default.
• W2078733356 cites W2089274331 @default.
• W2078733356 cites W2094918235 @default.
• W2078733356 cites W2102290181 @default.
• W2078733356 cites W2104602827 @default.
• W2078733356 cites W2105394148 @default.
• W2078733356 cites W2107900025 @default.
• W2078733356 cites W2110747672 @default.
• W2078733356 cites W2114642430 @default.
• W2078733356 cites W2115522595 @default.
• W2078733356 cites W2120055641 @default.
• W2078733356 cites W2131223670 @default.
• W2078733356 cites W2136022845 @default.
• W2078733356 cites W2143891326 @default.
• W2078733356 cites W2144325046 @default.
• W2078733356 cites W2146828510 @default.
• W2078733356 cites W2147033845 @default.
• W2078733356 cites W2148397587 @default.
• W2078733356 cites W2165508369 @default.
• W2078733356 cites W2168373965 @default.
• W2078733356 cites W2318576755 @default.
• W2078733356 cites W2410899317 @default.
• W2078733356 cites W25043755 @default.
• W2078733356 cites W4211156221 @default.
• W2078733356 cites W4235823143 @default.
• W2078733356 cites W4236575516 @default.
• W2078733356 cites W4237649186 @default.
• W2078733356 doi "https://doi.org/10.1016/j.biopsych.2012.07.026" @default.
• W2078733356 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22921454" @default.
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