FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078741210> ?p ?o ?g. }

• W2078741210 endingPage "361" @default.
• W2078741210 startingPage "353" @default.
• W2078741210 abstract "Use of the aldosterone-to-renin ratio (ARR) has suggested that at least one in 10 hypertensive subjects have primary aldosteronism (PA). There is thus a timely need to review the literature for effective drug therapies and to speculate on other therapeutic options by taking into account recent advances in understanding of the PA disease pathophysiological process.A MEDLINE and EMBASE search of all articles published from the start of the databases until July 1999 and reviews of the bibliographies of textbooks.Primary research articles on the medical treatment of PA with emphasis on diagnosis, treatment option, drug dosage, therapeutic response and adverse drug effect.Study design and quality were assessed. Relevant data on diagnostic methodology, drug usage and response were analysed and compared.A select number of subjects with aldosterone-producing adenoma (APA) can be expected to respond well to surgical treatment For the majority of PA cases especially subjects with idiopathic hyperaldosteronism (IHA), long-term medical treatment is now safe and feasible although no randomized controlled trials have been carried out to date. The best therapeutic response is obtained by directly antagonizing aldosterone at the receptor level using medium to low dose spironolactone and this response can be predicted by a raised ARR. The response to other potassium-sparing diuretics and calcium channel blockers are modest. IHA responds better than angiotensin II-unresponsive APA to angiotensin converting enzyme inhibitors and this may also be true with angiotensin II receptor blockers. The discovery of the aldosterone synthase gene opens up the possibility for gene therapy.The diagnosis of PA allows appropriate management with resultant blood pressure control in many hypertensive subjects who otherwise have resistant hypertension despite multiple drug therapy." @default.
• W2078741210 created "2016-06-24" @default.
• W2078741210 creator A5053151541 @default.
• W2078741210 creator A5057382848 @default.
• W2078741210 creator A5081246882 @default.
• W2078741210 date "2001-03-01" @default.
• W2078741210 modified "2023-10-11" @default.
• W2078741210 title "A review of the medical treatment of primary aldosteronism" @default.
• W2078741210 cites W1541612403 @default.
• W2078741210 cites W1603490609 @default.
• W2078741210 cites W1965973499 @default.
• W2078741210 cites W1970195303 @default.
• W2078741210 cites W1975847524 @default.
• W2078741210 cites W1976380515 @default.
• W2078741210 cites W1986477804 @default.
• W2078741210 cites W1992093466 @default.
• W2078741210 cites W2001053537 @default.
• W2078741210 cites W2001601001 @default.
• W2078741210 cites W2006999343 @default.
• W2078741210 cites W2015769117 @default.
• W2078741210 cites W2020415448 @default.
• W2078741210 cites W2025302968 @default.
• W2078741210 cites W2028589480 @default.
• W2078741210 cites W2029607709 @default.
• W2078741210 cites W2031135412 @default.
• W2078741210 cites W2031665777 @default.
• W2078741210 cites W2033296363 @default.
• W2078741210 cites W2035896957 @default.
• W2078741210 cites W2036247250 @default.
• W2078741210 cites W2038051166 @default.
• W2078741210 cites W2038227770 @default.
• W2078741210 cites W2039397242 @default.
• W2078741210 cites W2042552892 @default.
• W2078741210 cites W2048041131 @default.
• W2078741210 cites W2049745875 @default.
• W2078741210 cites W2050493582 @default.
• W2078741210 cites W2051617480 @default.
• W2078741210 cites W2053050837 @default.
• W2078741210 cites W2053579877 @default.
• W2078741210 cites W2061135005 @default.
• W2078741210 cites W2063753451 @default.
• W2078741210 cites W2064320461 @default.
• W2078741210 cites W2067263206 @default.
• W2078741210 cites W2072074888 @default.
• W2078741210 cites W2074502593 @default.
• W2078741210 cites W2076541362 @default.
• W2078741210 cites W2081471132 @default.
• W2078741210 cites W2085182906 @default.
• W2078741210 cites W2089481347 @default.
• W2078741210 cites W2099567527 @default.
• W2078741210 cites W2104034826 @default.
• W2078741210 cites W2111515893 @default.
• W2078741210 cites W2114892112 @default.
• W2078741210 cites W2115973414 @default.
• W2078741210 cites W2124738746 @default.
• W2078741210 cites W2130530500 @default.
• W2078741210 cites W2139847730 @default.
• W2078741210 cites W2143442116 @default.
• W2078741210 cites W2146059439 @default.
• W2078741210 cites W2149996020 @default.
• W2078741210 cites W2154375739 @default.
• W2078741210 cites W2167549446 @default.
• W2078741210 cites W2187012015 @default.
• W2078741210 cites W2312673624 @default.
• W2078741210 cites W2318174853 @default.
• W2078741210 cites W2323458614 @default.
• W2078741210 cites W2334678071 @default.
• W2078741210 cites W2399424898 @default.
• W2078741210 cites W2407497141 @default.
• W2078741210 cites W4231249271 @default.
• W2078741210 cites W4235718974 @default.
• W2078741210 cites W4253045252 @default.
• W2078741210 cites W4296588245 @default.
• W2078741210 cites W1998925273 @default.
• W2078741210 doi "https://doi.org/10.1097/00004872-200103000-00001" @default.
• W2078741210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11288803" @default.
• W2078741210 hasPublicationYear "2001" @default.
• W2078741210 type Work @default.
• W2078741210 sameAs 2078741210 @default.
• W2078741210 citedByCount "180" @default.
• W2078741210 countsByYear W20787412102012 @default.
• W2078741210 countsByYear W20787412102013 @default.
• W2078741210 countsByYear W20787412102014 @default.
• W2078741210 countsByYear W20787412102015 @default.
• W2078741210 countsByYear W20787412102016 @default.
• W2078741210 countsByYear W20787412102017 @default.
• W2078741210 countsByYear W20787412102018 @default.
• W2078741210 countsByYear W20787412102019 @default.
• W2078741210 countsByYear W20787412102020 @default.
• W2078741210 countsByYear W20787412102021 @default.
• W2078741210 countsByYear W20787412102022 @default.
• W2078741210 countsByYear W20787412102023 @default.
• W2078741210 crossrefType "journal-article" @default.
• W2078741210 hasAuthorship W2078741210A5053151541 @default.
• W2078741210 hasAuthorship W2078741210A5057382848 @default.
• W2078741210 hasAuthorship W2078741210A5081246882 @default.
• W2078741210 hasConcept C104849204 @default.
• W2078741210 hasConcept C126322002 @default.

• next