Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078742810> ?p ?o ?g. }
- W2078742810 endingPage "3288" @default.
- W2078742810 startingPage "3278" @default.
- W2078742810 abstract "The stemness state is characterized by self-renewal and differentiation properties. However, stem cells are not able to preserve these characteristics in long-term culture because of the intrinsic fragility of their phenotype easily undergoing senescence or neoplastic transformation. Furthermore, although isolated from the same original tissue using similar protocols, adult stem cells can display dissimilar phenotypes and important cell clone/species contamination. Finally, the lack of a clear standardization contributes to complicate the comprehension about the stemness condition. In this context, cell lines displaying a particularly stable phenotype must be identified to define one or multiple benchmarks against which other stem cell lines could be reliably assessed. The present paper demonstrates that it is possible to isolate from the rat dental pulp a stem cell line (MUR-1) that does not display neoplastic transformation in long-term culture. MUR-1 cells stably express a broad range of stemness markers and are able to differentiate into adipogenic, osteogenic, chondrogenic, neurogenic, and cardiomyogenic lineages independently of the culture passages. Moreover, serial in vitro passages have not changed their immunophenotype, proliferation capacity, or differentiation potential. The uniqueness of these characteristics candidates MUR-1 as a model to reliably improve the understanding of the mechanisms governing the stem cell fate in the same as well as in other stem cell populations." @default.
- W2078742810 created "2016-06-24" @default.
- W2078742810 creator A5000004537 @default.
- W2078742810 creator A5000899819 @default.
- W2078742810 creator A5006446931 @default.
- W2078742810 creator A5012525221 @default.
- W2078742810 creator A5025892630 @default.
- W2078742810 creator A5041724205 @default.
- W2078742810 creator A5053491148 @default.
- W2078742810 creator A5058315925 @default.
- W2078742810 creator A5058674640 @default.
- W2078742810 creator A5061965810 @default.
- W2078742810 creator A5074304059 @default.
- W2078742810 date "2012-12-10" @default.
- W2078742810 modified "2023-10-16" @default.
- W2078742810 title "Self-Renewal and Multipotency Coexist in a Long-Term Cultured Adult Rat Dental Pulp Stem Cell Line: An Exception to the Rule?" @default.
- W2078742810 cites W1514351476 @default.
- W2078742810 cites W1544751778 @default.
- W2078742810 cites W1554920990 @default.
- W2078742810 cites W1561427403 @default.
- W2078742810 cites W1816158752 @default.
- W2078742810 cites W1965903389 @default.
- W2078742810 cites W1969866392 @default.
- W2078742810 cites W1970530378 @default.
- W2078742810 cites W1970540079 @default.
- W2078742810 cites W1974207011 @default.
- W2078742810 cites W1977950302 @default.
- W2078742810 cites W1978683461 @default.
- W2078742810 cites W1979431956 @default.
- W2078742810 cites W1980867815 @default.
- W2078742810 cites W1984099131 @default.
- W2078742810 cites W1988451304 @default.
- W2078742810 cites W1993640536 @default.
- W2078742810 cites W1994172589 @default.
- W2078742810 cites W1996884864 @default.
- W2078742810 cites W2014673628 @default.
- W2078742810 cites W2017713326 @default.
- W2078742810 cites W2023321396 @default.
- W2078742810 cites W2024843140 @default.
- W2078742810 cites W2025371271 @default.
- W2078742810 cites W2027736364 @default.
- W2078742810 cites W2027740915 @default.
- W2078742810 cites W2027981595 @default.
- W2078742810 cites W2030128067 @default.
- W2078742810 cites W2035176325 @default.
- W2078742810 cites W2036550391 @default.
- W2078742810 cites W2040324519 @default.
- W2078742810 cites W2040856926 @default.
- W2078742810 cites W2041385580 @default.
- W2078742810 cites W2045456080 @default.
- W2078742810 cites W2048365950 @default.
- W2078742810 cites W2052898605 @default.
- W2078742810 cites W2053797631 @default.
- W2078742810 cites W2054216371 @default.
- W2078742810 cites W2055116714 @default.
- W2078742810 cites W2055670245 @default.
- W2078742810 cites W2058375497 @default.
- W2078742810 cites W2058969559 @default.
- W2078742810 cites W2066719891 @default.
- W2078742810 cites W2071433207 @default.
- W2078742810 cites W2072806829 @default.
- W2078742810 cites W2075328360 @default.
- W2078742810 cites W2077264573 @default.
- W2078742810 cites W2087592242 @default.
- W2078742810 cites W2103637156 @default.
- W2078742810 cites W2111081538 @default.
- W2078742810 cites W2125987139 @default.
- W2078742810 cites W2126068683 @default.
- W2078742810 cites W2130516299 @default.
- W2078742810 cites W2139814462 @default.
- W2078742810 cites W2140171665 @default.
- W2078742810 cites W2142410730 @default.
- W2078742810 cites W2143076230 @default.
- W2078742810 cites W2145040826 @default.
- W2078742810 cites W2154330374 @default.
- W2078742810 cites W2157285575 @default.
- W2078742810 cites W2158048826 @default.
- W2078742810 cites W2165238834 @default.
- W2078742810 cites W2595308412 @default.
- W2078742810 cites W4252245952 @default.
- W2078742810 doi "https://doi.org/10.1089/scd.2012.0141" @default.
- W2078742810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22582744" @default.
- W2078742810 hasPublicationYear "2012" @default.
- W2078742810 type Work @default.
- W2078742810 sameAs 2078742810 @default.
- W2078742810 citedByCount "10" @default.
- W2078742810 countsByYear W20787428102012 @default.
- W2078742810 countsByYear W20787428102013 @default.
- W2078742810 countsByYear W20787428102014 @default.
- W2078742810 countsByYear W20787428102016 @default.
- W2078742810 countsByYear W20787428102017 @default.
- W2078742810 countsByYear W20787428102021 @default.
- W2078742810 countsByYear W20787428102022 @default.
- W2078742810 crossrefType "journal-article" @default.
- W2078742810 hasAuthorship W2078742810A5000004537 @default.
- W2078742810 hasAuthorship W2078742810A5000899819 @default.
- W2078742810 hasAuthorship W2078742810A5006446931 @default.
- W2078742810 hasAuthorship W2078742810A5012525221 @default.