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- W2078743071 abstract "Previous behavioral and pharmacological studies have implicated endorphins in radiation-induced locomotor hyperactivity of the C57BL/6J mouse. However, the endogenous opiate(s) responsible for this behavioral change have not been identified. The present study measured beta-endorphin-like immunoreactivity (beta-END-LI) in brain, blood, and combined brain and pituitary samples from irradiated and sham-irradiated C57BL/6J mice. After radiation exposure, levels of beta-END-LI decreased significantly in the brain. A similar, but not statistically significant, decline was measured in combined brain and pituitary samples. Concentrations of blood beta-END-LI were not changed by irradiation. These radiogenic changes in beta-END-LI are in some ways similar to those observed after other stresses. However, radiation-induced locomotor hyperactivity may be mediated more by alterations of beta-END-LI in the brain than in the periphery. Other endogenous opiate systems may also contribute to this behavioral change in the C57BL/6J mouse." @default.
- W2078743071 created "2016-06-24" @default.
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- W2078743071 date "1983-12-01" @default.
- W2078743071 modified "2023-09-25" @default.
- W2078743071 title "Ionizing radiation alters beta-endorphin-like immunoreactivity in brain but not blood" @default.
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- W2078743071 doi "https://doi.org/10.1016/0091-3057(83)90402-1" @default.
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