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• W2078743327 abstract "The intestinal transport of L‐methionine has been investigated in brush‐border membrane vesicles isolated from the jejunum of 6‐week‐old chickens. L‐Methionine influx is mediated by passive diffusion and by Na + ‐dependent and Na + ‐independent carrier‐mediated mechanisms. In the absence of Na + , cis‐ inhibition experiments with neutral and cationic amino acids indicate that two transport components are involved in L‐methionine influx: one sensitive to L‐lysine and the other sensitive to 2‐aminobicyclo[2.2.1]heptane‐2‐carboxylic acid (BCH). The L‐lysine‐sensitive flux is strongly inhibited by L‐phenylalanine and can be broken down into two pathways, one sensitive to N‐ ethylmaleimide (NEM) and the other to L‐glutamine and L‐cystine. The kinetics of L‐methionine influx in Na + ‐free conditions is described by a model involving three transport systems, here called a,b and c: systems a and b are able to interact with cationic amino acids but differ in their kinetic characteristics (system a: K m = 2.2 ± 0.3 μM and V max = 0.13 ± 0.005 pmol (mg protein) −1 (2 s) −1 ; system b: K m = 3.0 ± 0.3 mM and V max = 465 ± 4.3 pmol (mg protein) −1 (2 s) −1 ); system c is specific for neutral amino acids, has a K m of 1.29 ± 0.08 mM and a V max of 229 ± 5.0 pmol (mg protein) −1 (2 s) −1 and is sensitive to BCH inhibition. The Na + ‐dependent component can be inhibited by BCH and L‐phenylalanine but cannot interact either with cationic amino acids or with α‐(methylamino)isobutyrate (MeAIB). The kinetic analysis of L‐methionine influx under a Na + gradient confirms the activity of the above described transport systems a and b. System a is not affected by the presence of Na + while system b shows a 3‐fold decrease in the Michaelis constant and a 1.4‐fold increase in V max . In the presence of Na + , the BCH‐sensitive component can be subdivided into two pathways: one corresponds to system c and the other is Na + dependent and has a K m of 0.64 ± 0.013 mM and a V max of 391 ± 2.3 pmol (mg protein) −1 (2 s) −1 . It is concluded that L‐methionine is transported in the chicken jejunum by four transport systems, one with functional characteristics similar to those of system b o, + (system a); a second (system b ) similar to system y + , which we suggest naming y + m to account for its high V max for L‐methionine transport in the absence of Na + ; a third (system c ) which is Na + independent and has similar properties to system L; and a fourth showing Na + dependence and tentatively identified with system B." @default.
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• W2078743327 date "1998-06-01" @default.
• W2078743327 modified "2023-10-15" @default.
• W2078743327 title "Multiple pathways for L-methionine transport in brush-border membrane vesicles from chicken jejunum" @default.
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• W2078743327 doi "https://doi.org/10.1111/j.1469-7793.1998.527bn.x" @default.
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