Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078747972> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2078747972 endingPage "189" @default.
- W2078747972 startingPage "181" @default.
- W2078747972 abstract "S21400 (AERODIOL) is a new intranasal formulation of 17beta-estradiol. It provides a pulsed estrogen therapy that ensures sufficient estrogenisation of tissues to treat estrogen deficiency symptoms, particularly those of the menopause. This multicentric study was designed to determine dose-range, efficacy and acceptability of S21400. One hundred and thirty four women were allocated a daily dose of 100-900 microg for 12 weeks. The doses of 100, 600 and 900 microg were given in two daily administrations, the doses of 200, 300 and 450 microg were given in one and two daily administrations. Oral progestogen was added the last 10-14 days of each cycle of estrogen therapy in all non-hysterectomized women. S21400 showed a dose-effect relationship and provided adequate estrogenisation in more than 80% of patients receiving a dose ranging from 200 to 600 microg daily. Hormonal impregnation was judged sufficient in 23% of women receiving the lowest dose (100 microg). It was often considered excessive for daily doses of 900 microg (36%). After 12 weeks of treatment, efficacy was similar whether the total daily dose was given in one or two administrations. Treatment was well tolerated and accepted, with only minor nasal events (prickling, sneezing). It was perceived by 92% of patients as good or excellent and 81% chose to continue the nasal treatment when it was offered to them. An initial dose of 300 microg per day provides an optimal efficacy/tolerability ratio. In summary, the pulsed estrogen therapy with AERODIOL in one daily administration offers a safe, well accepted and highly effective treatment to alleviate climacteric symptoms. It can be adapted easily to ensure optimal clinical efficacy." @default.
- W2078747972 created "2016-06-24" @default.
- W2078747972 creator A5005943609 @default.
- W2078747972 creator A5012016821 @default.
- W2078747972 creator A5034349442 @default.
- W2078747972 creator A5038351724 @default.
- W2078747972 creator A5043739549 @default.
- W2078747972 creator A5063363547 @default.
- W2078747972 creator A5068422809 @default.
- W2078747972 creator A5082489519 @default.
- W2078747972 creator A5082719657 @default.
- W2078747972 creator A5087010701 @default.
- W2078747972 date "2001-01-01" @default.
- W2078747972 modified "2023-10-05" @default.
- W2078747972 title "Clinical evaluation, dose-finding and acceptability of AERODIOL®, the pulsed estrogen therapy for treatment of climacteric symptoms" @default.
- W2078747972 cites W1963514718 @default.
- W2078747972 cites W1972987732 @default.
- W2078747972 cites W1976879422 @default.
- W2078747972 cites W2007824063 @default.
- W2078747972 cites W2011247197 @default.
- W2078747972 cites W2034642847 @default.
- W2078747972 cites W2047001294 @default.
- W2078747972 cites W2057635337 @default.
- W2078747972 cites W2058956606 @default.
- W2078747972 cites W2089714738 @default.
- W2078747972 cites W2097506722 @default.
- W2078747972 cites W2159394406 @default.
- W2078747972 doi "https://doi.org/10.1016/s0378-5122(00)00175-4" @default.
- W2078747972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11173180" @default.
- W2078747972 hasPublicationYear "2001" @default.
- W2078747972 type Work @default.
- W2078747972 sameAs 2078747972 @default.
- W2078747972 citedByCount "23" @default.
- W2078747972 countsByYear W20787479722014 @default.
- W2078747972 countsByYear W20787479722017 @default.
- W2078747972 countsByYear W20787479722018 @default.
- W2078747972 countsByYear W20787479722020 @default.
- W2078747972 countsByYear W20787479722022 @default.
- W2078747972 crossrefType "journal-article" @default.
- W2078747972 hasAuthorship W2078747972A5005943609 @default.
- W2078747972 hasAuthorship W2078747972A5012016821 @default.
- W2078747972 hasAuthorship W2078747972A5034349442 @default.
- W2078747972 hasAuthorship W2078747972A5038351724 @default.
- W2078747972 hasAuthorship W2078747972A5043739549 @default.
- W2078747972 hasAuthorship W2078747972A5063363547 @default.
- W2078747972 hasAuthorship W2078747972A5068422809 @default.
- W2078747972 hasAuthorship W2078747972A5082489519 @default.
- W2078747972 hasAuthorship W2078747972A5082719657 @default.
- W2078747972 hasAuthorship W2078747972A5087010701 @default.
- W2078747972 hasConcept C126322002 @default.
- W2078747972 hasConcept C142724271 @default.
- W2078747972 hasConcept C197934379 @default.
- W2078747972 hasConcept C198454886 @default.
- W2078747972 hasConcept C204787440 @default.
- W2078747972 hasConcept C27081682 @default.
- W2078747972 hasConcept C2776312127 @default.
- W2078747972 hasConcept C2777164284 @default.
- W2078747972 hasConcept C2778375690 @default.
- W2078747972 hasConcept C2778562196 @default.
- W2078747972 hasConcept C2780572241 @default.
- W2078747972 hasConcept C29456083 @default.
- W2078747972 hasConcept C2991744798 @default.
- W2078747972 hasConcept C71924100 @default.
- W2078747972 hasConceptScore W2078747972C126322002 @default.
- W2078747972 hasConceptScore W2078747972C142724271 @default.
- W2078747972 hasConceptScore W2078747972C197934379 @default.
- W2078747972 hasConceptScore W2078747972C198454886 @default.
- W2078747972 hasConceptScore W2078747972C204787440 @default.
- W2078747972 hasConceptScore W2078747972C27081682 @default.
- W2078747972 hasConceptScore W2078747972C2776312127 @default.
- W2078747972 hasConceptScore W2078747972C2777164284 @default.
- W2078747972 hasConceptScore W2078747972C2778375690 @default.
- W2078747972 hasConceptScore W2078747972C2778562196 @default.
- W2078747972 hasConceptScore W2078747972C2780572241 @default.
- W2078747972 hasConceptScore W2078747972C29456083 @default.
- W2078747972 hasConceptScore W2078747972C2991744798 @default.
- W2078747972 hasConceptScore W2078747972C71924100 @default.
- W2078747972 hasIssue "3" @default.
- W2078747972 hasLocation W20787479721 @default.
- W2078747972 hasLocation W20787479722 @default.
- W2078747972 hasOpenAccess W2078747972 @default.
- W2078747972 hasPrimaryLocation W20787479721 @default.
- W2078747972 hasRelatedWork W1984316546 @default.
- W2078747972 hasRelatedWork W2073947704 @default.
- W2078747972 hasRelatedWork W2102418794 @default.
- W2078747972 hasRelatedWork W2115023228 @default.
- W2078747972 hasRelatedWork W2403503433 @default.
- W2078747972 hasRelatedWork W2463785292 @default.
- W2078747972 hasRelatedWork W4229752162 @default.
- W2078747972 hasRelatedWork W4230924817 @default.
- W2078747972 hasRelatedWork W4244771339 @default.
- W2078747972 hasRelatedWork W2214793386 @default.
- W2078747972 hasVolume "37" @default.
- W2078747972 isParatext "false" @default.
- W2078747972 isRetracted "false" @default.
- W2078747972 magId "2078747972" @default.
- W2078747972 workType "article" @default.