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• W2078748046 startingPage "611" @default.
• W2078748046 abstract "Insects have frequently evolved mutualistic relationships with extracellular and/or intracellular bacterial endosymbionts. Infection with endosymbionts seems to affect several cellular functions of the host such as immune pathways, oxidative stress regulation and autophagy. Our current knowledge about specific host factors leading to endosymbiont tolerance and/or control is still scarce and is based on very few associations between insect hosts and bacteria only. Camponotus floridanus ants harbour the obligate intracellular bacterium Blochmannia floridanus within specialized midgut cells called bacteriocytes. The number of Blochmannia endosymbionts within the midgut tissue increases strongly during host development and reaches a maximum at the late pupal stage, where the entire midgut is transformed into a symbiotic organ. After eclosion of workers the number of Blochmannia strongly decreases again. We chose 15 candidate genes from C. floridanus likely to be involved in host-symbiont interactions based on their significant homology to previously investigated symbiosis-relevant genes from other insects. We determined the expression of these genes in the endosymbiont-bearing midgut tissue in comparison to the residual body tissue at different developmental stages of C. floridanus in order to reveal changes in gene expression correlating with changes in endosymbiont number per host. Strikingly, two pattern recognition receptors (amidase PGRP-LB and PGRP-SC2) were highly expressed in the midgut tissue at the pupal stage, potentially down-modulating the IMD pathway to enable endosymbiont tolerance. Moreover, we investigated the immune gene expression in response to bacterial challenge at the pupal stage. Results showed that the midgut tissue differs in expression pattern in contrast to the residual body. Our results support a key role for amidase PGRPs, especially PGRP-LB, in regulation of the immune response towards endosymbionts in C. floridanus and suggest an involvement of the lysosomal system in control of Blochmannia endosymbionts." @default.
• W2078748046 created "2016-06-24" @default.
• W2078748046 creator A5018587960 @default.
• W2078748046 creator A5029750346 @default.
• W2078748046 creator A5069501849 @default.
• W2078748046 date "2013-06-01" @default.
• W2078748046 modified "2023-09-25" @default.
• W2078748046 title "Gene expression analysis of the endosymbiont-bearing midgut tissue during ontogeny of the carpenter ant Camponotus floridanus" @default.
• W2078748046 cites W1479939900 @default.
• W2078748046 cites W1558387872 @default.
• W2078748046 cites W1561229372 @default.
• W2078748046 cites W1908461678 @default.
• W2078748046 cites W1963781115 @default.
• W2078748046 cites W1966291468 @default.
• W2078748046 cites W1966732621 @default.
• W2078748046 cites W1966963462 @default.
• W2078748046 cites W1970426009 @default.
• W2078748046 cites W1971116536 @default.
• W2078748046 cites W1971748043 @default.
• W2078748046 cites W1972462926 @default.
• W2078748046 cites W1973597902 @default.
• W2078748046 cites W1974555103 @default.
• W2078748046 cites W1975501068 @default.
• W2078748046 cites W1981025988 @default.
• W2078748046 cites W1981417468 @default.
• W2078748046 cites W1984133423 @default.
• W2078748046 cites W1987320140 @default.
• W2078748046 cites W1988016047 @default.
• W2078748046 cites W1989719456 @default.
• W2078748046 cites W1994586595 @default.
• W2078748046 cites W2000530029 @default.
• W2078748046 cites W2000667679 @default.
• W2078748046 cites W2002213182 @default.
• W2078748046 cites W2006768051 @default.
• W2078748046 cites W2011515559 @default.
• W2078748046 cites W2015160750 @default.
• W2078748046 cites W2015560964 @default.
• W2078748046 cites W2020664730 @default.
• W2078748046 cites W2026457004 @default.
• W2078748046 cites W2029014358 @default.
• W2078748046 cites W2034948731 @default.
• W2078748046 cites W2035241610 @default.
• W2078748046 cites W2036933537 @default.
• W2078748046 cites W2043669567 @default.
• W2078748046 cites W2048869977 @default.
• W2078748046 cites W2049395582 @default.
• W2078748046 cites W2052104837 @default.
• W2078748046 cites W2052129538 @default.
• W2078748046 cites W2059145665 @default.
• W2078748046 cites W2063523235 @default.
• W2078748046 cites W2064082040 @default.
• W2078748046 cites W2073980858 @default.
• W2078748046 cites W2074636100 @default.
• W2078748046 cites W2074898833 @default.
• W2078748046 cites W2075570572 @default.
• W2078748046 cites W2077906612 @default.
• W2078748046 cites W2079639127 @default.
• W2078748046 cites W2079825884 @default.
• W2078748046 cites W2080359892 @default.
• W2078748046 cites W2080924129 @default.
• W2078748046 cites W2081613273 @default.
• W2078748046 cites W2084394087 @default.
• W2078748046 cites W2085070954 @default.
• W2078748046 cites W2086341363 @default.
• W2078748046 cites W2088787651 @default.
• W2078748046 cites W2099824652 @default.
• W2078748046 cites W2100241857 @default.
• W2078748046 cites W2100993985 @default.
• W2078748046 cites W2102549002 @default.
• W2078748046 cites W2104092777 @default.
• W2078748046 cites W2107277218 @default.
• W2078748046 cites W2116016820 @default.
• W2078748046 cites W2117715561 @default.
• W2078748046 cites W2117777628 @default.
• W2078748046 cites W2120906459 @default.
• W2078748046 cites W2123495423 @default.
• W2078748046 cites W2123759872 @default.
• W2078748046 cites W2123836324 @default.
• W2078748046 cites W2124786856 @default.
• W2078748046 cites W2132962075 @default.
• W2078748046 cites W2136274814 @default.
• W2078748046 cites W2138474497 @default.
• W2078748046 cites W2150825041 @default.
• W2078748046 cites W2152770371 @default.
• W2078748046 cites W2153001833 @default.
• W2078748046 cites W2159267296 @default.
• W2078748046 cites W2159492807 @default.
• W2078748046 cites W2161340990 @default.
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• W2078748046 doi "https://doi.org/10.1016/j.jinsphys.2013.03.011" @default.
• W2078748046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23570961" @default.
• W2078748046 hasPublicationYear "2013" @default.
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