FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078751569> ?p ?o ?g. }

• W2078751569 endingPage "1233" @default.
• W2078751569 startingPage "1224" @default.
• W2078751569 abstract "Several epidemiological studies suggested that treatment with angiotensin II type 1 receptor blocker (ARB) provided a risk reduction of developing type 2 diabetes. In this study, we investigated whether and how ARB treatment can improve abnormalities of pancreatic islets in diabetes state. We randomized db/db mice, a model of type 2 diabetes with obesity, at the age of 8 weeks to receive candesartan, an ARB, for 6 weeks. We also studied age-matched db/misty mice as control. Glucose tolerance test revealed that candesartan treatment improved glucose tolerance with the modest increase in serum insulin level in db/db mice. Concurrently, candesartan increased beta-cell mass, increased staining intensity of insulin, and decreased staining intensity of components of NAD(P)H oxidase, p22phox and gp91phox, and those of oxidative stress markers in beta-cells. These changes were accompanied by reduction of mitochondrial volume. Treatment with candesartan also reduced fibrosis in and around the islets and prevented the loss of endothelial cells in islets. Our results showed that candesartan partially prevented deterioration of glucose tolerance by providing protection against progressive beta-cell damage in diabetes." @default.
• W2078751569 created "2016-06-24" @default.
• W2078751569 creator A5017309843 @default.
• W2078751569 creator A5032317621 @default.
• W2078751569 creator A5037878079 @default.
• W2078751569 creator A5039673545 @default.
• W2078751569 creator A5043599747 @default.
• W2078751569 creator A5043895658 @default.
• W2078751569 creator A5049677961 @default.
• W2078751569 creator A5062525338 @default.
• W2078751569 creator A5067038356 @default.
• W2078751569 creator A5070547255 @default.
• W2078751569 date "2006-06-01" @default.
• W2078751569 modified "2023-10-16" @default.
• W2078751569 title "Beneficial effects of candesartan, an angiotensin II type 1 receptor blocker, on β-cell function and morphology in db/db mice" @default.
• W2078751569 cites W1502283651 @default.
• W2078751569 cites W1542041608 @default.
• W2078751569 cites W1604160535 @default.
• W2078751569 cites W180946569 @default.
• W2078751569 cites W1966156012 @default.
• W2078751569 cites W1977887431 @default.
• W2078751569 cites W1989352421 @default.
• W2078751569 cites W1990001566 @default.
• W2078751569 cites W1992716613 @default.
• W2078751569 cites W2005754586 @default.
• W2078751569 cites W2010086727 @default.
• W2078751569 cites W2019468531 @default.
• W2078751569 cites W2025442136 @default.
• W2078751569 cites W2027808216 @default.
• W2078751569 cites W2034129642 @default.
• W2078751569 cites W2059467226 @default.
• W2078751569 cites W2097784879 @default.
• W2078751569 cites W2098816300 @default.
• W2078751569 cites W2099142346 @default.
• W2078751569 cites W2103144484 @default.
• W2078751569 cites W2103908751 @default.
• W2078751569 cites W2111190158 @default.
• W2078751569 cites W2113544353 @default.
• W2078751569 cites W2116209576 @default.
• W2078751569 cites W2123766698 @default.
• W2078751569 cites W2124211797 @default.
• W2078751569 cites W2132557269 @default.
• W2078751569 cites W2139016545 @default.
• W2078751569 cites W2143256430 @default.
• W2078751569 cites W2144673000 @default.
• W2078751569 cites W2145713912 @default.
• W2078751569 cites W2153769155 @default.
• W2078751569 cites W2154784486 @default.
• W2078751569 cites W2156044622 @default.
• W2078751569 cites W2159632385 @default.
• W2078751569 cites W2159766146 @default.
• W2078751569 doi "https://doi.org/10.1016/j.bbrc.2006.04.011" @default.
• W2078751569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16650382" @default.
• W2078751569 hasPublicationYear "2006" @default.
• W2078751569 type Work @default.
• W2078751569 sameAs 2078751569 @default.
• W2078751569 citedByCount "84" @default.
• W2078751569 countsByYear W20787515692012 @default.
• W2078751569 countsByYear W20787515692013 @default.
• W2078751569 countsByYear W20787515692014 @default.
• W2078751569 countsByYear W20787515692015 @default.
• W2078751569 countsByYear W20787515692016 @default.
• W2078751569 countsByYear W20787515692017 @default.
• W2078751569 countsByYear W20787515692019 @default.
• W2078751569 countsByYear W20787515692020 @default.
• W2078751569 countsByYear W20787515692021 @default.
• W2078751569 countsByYear W20787515692022 @default.
• W2078751569 countsByYear W20787515692023 @default.
• W2078751569 crossrefType "journal-article" @default.
• W2078751569 hasAuthorship W2078751569A5017309843 @default.
• W2078751569 hasAuthorship W2078751569A5032317621 @default.
• W2078751569 hasAuthorship W2078751569A5037878079 @default.
• W2078751569 hasAuthorship W2078751569A5039673545 @default.
• W2078751569 hasAuthorship W2078751569A5043599747 @default.
• W2078751569 hasAuthorship W2078751569A5043895658 @default.
• W2078751569 hasAuthorship W2078751569A5049677961 @default.
• W2078751569 hasAuthorship W2078751569A5062525338 @default.
• W2078751569 hasAuthorship W2078751569A5067038356 @default.
• W2078751569 hasAuthorship W2078751569A5070547255 @default.
• W2078751569 hasConcept C104849204 @default.
• W2078751569 hasConcept C126322002 @default.
• W2078751569 hasConcept C134018914 @default.
• W2078751569 hasConcept C165220095 @default.
• W2078751569 hasConcept C170493617 @default.
• W2078751569 hasConcept C2776151105 @default.
• W2078751569 hasConcept C2776828364 @default.
• W2078751569 hasConcept C2777180221 @default.
• W2078751569 hasConcept C2779306644 @default.
• W2078751569 hasConcept C2780036600 @default.
• W2078751569 hasConcept C2780609358 @default.
• W2078751569 hasConcept C2908929049 @default.
• W2078751569 hasConcept C555293320 @default.
• W2078751569 hasConcept C71924100 @default.
• W2078751569 hasConceptScore W2078751569C104849204 @default.
• W2078751569 hasConceptScore W2078751569C126322002 @default.
• W2078751569 hasConceptScore W2078751569C134018914 @default.
• W2078751569 hasConceptScore W2078751569C165220095 @default.
• W2078751569 hasConceptScore W2078751569C170493617 @default.

• next