Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078751570> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2078751570 endingPage "125" @default.
- W2078751570 startingPage "117" @default.
- W2078751570 abstract "An important quality feature of stability testing of drug products is mass balance. Besides several known or anticipated causes for mass imbalances, a further potential cause that has not yet been systematically assessed might be incomplete recovery due to the influence of matrix ageing. The genotoxic degradation product 4-chloroaniline (PCA) and the unstable drug substance estradiol (E2) that is known to be difficult to extract from matrices in low-dose solid formulations were chosen as examples. A marketed product containing E2 as well as two marketed products that potentially contain PCA were investigated together with experimental formulations containing E2 or PCA that were produced for this study. To accelerate drug product matrix ageing, samples were stored at different conditions for defined storage periods. PCA and E2 recovery was determined at all sampling time points, respectively. In comparison to unstressed samples, significant changes in recovery were observed in 67% of the formulations investigated. Consequently, the outlined procedure can be regarded as a promising approach to reveal potential reasons for mass imbalance." @default.
- W2078751570 created "2016-06-24" @default.
- W2078751570 creator A5023105426 @default.
- W2078751570 creator A5033197577 @default.
- W2078751570 creator A5064663460 @default.
- W2078751570 creator A5090484754 @default.
- W2078751570 date "2013-02-01" @default.
- W2078751570 modified "2023-10-12" @default.
- W2078751570 title "Changes in recovery due to drug product matrix ageing as a source of mass imbalances" @default.
- W2078751570 cites W1964640305 @default.
- W2078751570 cites W1972358942 @default.
- W2078751570 cites W1975714885 @default.
- W2078751570 cites W1988308747 @default.
- W2078751570 cites W1994050049 @default.
- W2078751570 cites W1997353911 @default.
- W2078751570 cites W2004906271 @default.
- W2078751570 cites W2011897414 @default.
- W2078751570 cites W2013507357 @default.
- W2078751570 cites W2036991953 @default.
- W2078751570 cites W2038575665 @default.
- W2078751570 cites W2039995547 @default.
- W2078751570 cites W2041769041 @default.
- W2078751570 cites W2050274306 @default.
- W2078751570 cites W2061356882 @default.
- W2078751570 cites W2085318990 @default.
- W2078751570 cites W2089828431 @default.
- W2078751570 cites W2118965123 @default.
- W2078751570 cites W2139048060 @default.
- W2078751570 cites W2160731254 @default.
- W2078751570 cites W2416830628 @default.
- W2078751570 doi "https://doi.org/10.1016/j.jpba.2012.10.014" @default.
- W2078751570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23245242" @default.
- W2078751570 hasPublicationYear "2013" @default.
- W2078751570 type Work @default.
- W2078751570 sameAs 2078751570 @default.
- W2078751570 citedByCount "3" @default.
- W2078751570 countsByYear W20787515702013 @default.
- W2078751570 countsByYear W20787515702017 @default.
- W2078751570 countsByYear W20787515702018 @default.
- W2078751570 crossrefType "journal-article" @default.
- W2078751570 hasAuthorship W2078751570A5023105426 @default.
- W2078751570 hasAuthorship W2078751570A5033197577 @default.
- W2078751570 hasAuthorship W2078751570A5064663460 @default.
- W2078751570 hasAuthorship W2078751570A5090484754 @default.
- W2078751570 hasConcept C106487976 @default.
- W2078751570 hasConcept C126322002 @default.
- W2078751570 hasConcept C127413603 @default.
- W2078751570 hasConcept C162356407 @default.
- W2078751570 hasConcept C183696295 @default.
- W2078751570 hasConcept C185592680 @default.
- W2078751570 hasConcept C2524010 @default.
- W2078751570 hasConcept C2779679103 @default.
- W2078751570 hasConcept C2780035454 @default.
- W2078751570 hasConcept C33923547 @default.
- W2078751570 hasConcept C41008148 @default.
- W2078751570 hasConcept C43617362 @default.
- W2078751570 hasConcept C500499127 @default.
- W2078751570 hasConcept C71924100 @default.
- W2078751570 hasConcept C76155785 @default.
- W2078751570 hasConcept C90673727 @default.
- W2078751570 hasConcept C98274493 @default.
- W2078751570 hasConceptScore W2078751570C106487976 @default.
- W2078751570 hasConceptScore W2078751570C126322002 @default.
- W2078751570 hasConceptScore W2078751570C127413603 @default.
- W2078751570 hasConceptScore W2078751570C162356407 @default.
- W2078751570 hasConceptScore W2078751570C183696295 @default.
- W2078751570 hasConceptScore W2078751570C185592680 @default.
- W2078751570 hasConceptScore W2078751570C2524010 @default.
- W2078751570 hasConceptScore W2078751570C2779679103 @default.
- W2078751570 hasConceptScore W2078751570C2780035454 @default.
- W2078751570 hasConceptScore W2078751570C33923547 @default.
- W2078751570 hasConceptScore W2078751570C41008148 @default.
- W2078751570 hasConceptScore W2078751570C43617362 @default.
- W2078751570 hasConceptScore W2078751570C500499127 @default.
- W2078751570 hasConceptScore W2078751570C71924100 @default.
- W2078751570 hasConceptScore W2078751570C76155785 @default.
- W2078751570 hasConceptScore W2078751570C90673727 @default.
- W2078751570 hasConceptScore W2078751570C98274493 @default.
- W2078751570 hasLocation W20787515701 @default.
- W2078751570 hasLocation W20787515702 @default.
- W2078751570 hasOpenAccess W2078751570 @default.
- W2078751570 hasPrimaryLocation W20787515701 @default.
- W2078751570 hasRelatedWork W1988156550 @default.
- W2078751570 hasRelatedWork W2012906904 @default.
- W2078751570 hasRelatedWork W2079106159 @default.
- W2078751570 hasRelatedWork W2345614571 @default.
- W2078751570 hasRelatedWork W2358940109 @default.
- W2078751570 hasRelatedWork W2392044770 @default.
- W2078751570 hasRelatedWork W2756093870 @default.
- W2078751570 hasRelatedWork W2775518447 @default.
- W2078751570 hasRelatedWork W4205795461 @default.
- W2078751570 hasRelatedWork W2136134918 @default.
- W2078751570 hasVolume "74" @default.
- W2078751570 isParatext "false" @default.
- W2078751570 isRetracted "false" @default.
- W2078751570 magId "2078751570" @default.
- W2078751570 workType "article" @default.