Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078752671> ?p ?o ?g. }
- W2078752671 endingPage "37" @default.
- W2078752671 startingPage "32" @default.
- W2078752671 abstract "The ideal gene-therapy vector for treating genetic disorders should deliver intact therapeutic genes and their essential regulatory elements into the specific “safe genomic site” and realize long-term, self-regulatory expression. For β-thalassemia gene therapy, viral vectors have been broadly used, but the accompanying insertional mutation and immunogenicity remain problematic. Hence, we aimed to develop new non-viral vectors that are efficient and safe in treating diseases. As previous studies have demonstrated that physiological expression of β-globin genes requires both a 5′ locus control region and 3′ specific elements, we constructed a new human chromosome-derived targeting vector to transfer the intact β-globin gene cluster into K562 cells. The whole β-globin gene cluster was precisely integrated into the target site and expressed in a self-regulatory pattern. The results proved that the human chromosome-derived vector was specifically targeted to the human genome and this could provide a novel platform for further gene therapy research." @default.
- W2078752671 created "2016-06-24" @default.
- W2078752671 creator A5012513461 @default.
- W2078752671 creator A5019565664 @default.
- W2078752671 creator A5026030459 @default.
- W2078752671 creator A5026206714 @default.
- W2078752671 creator A5042505106 @default.
- W2078752671 creator A5042995444 @default.
- W2078752671 creator A5049687384 @default.
- W2078752671 creator A5067534017 @default.
- W2078752671 creator A5071197747 @default.
- W2078752671 creator A5075889094 @default.
- W2078752671 creator A5079717997 @default.
- W2078752671 date "2007-04-01" @default.
- W2078752671 modified "2023-09-26" @default.
- W2078752671 title "Site-specific transfer of an intact β-globin gene cluster through a new targeting vector" @default.
- W2078752671 cites W1490324405 @default.
- W2078752671 cites W1523950660 @default.
- W2078752671 cites W1598569053 @default.
- W2078752671 cites W1988750924 @default.
- W2078752671 cites W1989424614 @default.
- W2078752671 cites W1997170085 @default.
- W2078752671 cites W2003103876 @default.
- W2078752671 cites W2008685326 @default.
- W2078752671 cites W2020977773 @default.
- W2078752671 cites W2041798627 @default.
- W2078752671 cites W2049109647 @default.
- W2078752671 cites W2050206304 @default.
- W2078752671 cites W2054406966 @default.
- W2078752671 cites W2056711252 @default.
- W2078752671 cites W2069093904 @default.
- W2078752671 cites W2075110532 @default.
- W2078752671 cites W2090126488 @default.
- W2078752671 cites W2104442199 @default.
- W2078752671 cites W2104799492 @default.
- W2078752671 cites W2105938039 @default.
- W2078752671 cites W2111444354 @default.
- W2078752671 cites W2118299921 @default.
- W2078752671 cites W2160615543 @default.
- W2078752671 cites W2170533808 @default.
- W2078752671 cites W2245575916 @default.
- W2078752671 cites W2404293426 @default.
- W2078752671 cites W4362204021 @default.
- W2078752671 cites W3151452517 @default.
- W2078752671 doi "https://doi.org/10.1016/j.bbrc.2007.02.074" @default.
- W2078752671 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17339031" @default.
- W2078752671 hasPublicationYear "2007" @default.
- W2078752671 type Work @default.
- W2078752671 sameAs 2078752671 @default.
- W2078752671 citedByCount "10" @default.
- W2078752671 countsByYear W20787526712012 @default.
- W2078752671 countsByYear W20787526712013 @default.
- W2078752671 countsByYear W20787526712015 @default.
- W2078752671 countsByYear W20787526712017 @default.
- W2078752671 crossrefType "journal-article" @default.
- W2078752671 hasAuthorship W2078752671A5012513461 @default.
- W2078752671 hasAuthorship W2078752671A5019565664 @default.
- W2078752671 hasAuthorship W2078752671A5026030459 @default.
- W2078752671 hasAuthorship W2078752671A5026206714 @default.
- W2078752671 hasAuthorship W2078752671A5042505106 @default.
- W2078752671 hasAuthorship W2078752671A5042995444 @default.
- W2078752671 hasAuthorship W2078752671A5049687384 @default.
- W2078752671 hasAuthorship W2078752671A5067534017 @default.
- W2078752671 hasAuthorship W2078752671A5071197747 @default.
- W2078752671 hasAuthorship W2078752671A5075889094 @default.
- W2078752671 hasAuthorship W2078752671A5079717997 @default.
- W2078752671 hasConcept C101762097 @default.
- W2078752671 hasConcept C104317684 @default.
- W2078752671 hasConcept C111599444 @default.
- W2078752671 hasConcept C141231307 @default.
- W2078752671 hasConcept C150194340 @default.
- W2078752671 hasConcept C32470452 @default.
- W2078752671 hasConcept C36857842 @default.
- W2078752671 hasConcept C39981086 @default.
- W2078752671 hasConcept C40767141 @default.
- W2078752671 hasConcept C54355233 @default.
- W2078752671 hasConcept C70721500 @default.
- W2078752671 hasConcept C84597430 @default.
- W2078752671 hasConcept C86803240 @default.
- W2078752671 hasConcept C92087593 @default.
- W2078752671 hasConceptScore W2078752671C101762097 @default.
- W2078752671 hasConceptScore W2078752671C104317684 @default.
- W2078752671 hasConceptScore W2078752671C111599444 @default.
- W2078752671 hasConceptScore W2078752671C141231307 @default.
- W2078752671 hasConceptScore W2078752671C150194340 @default.
- W2078752671 hasConceptScore W2078752671C32470452 @default.
- W2078752671 hasConceptScore W2078752671C36857842 @default.
- W2078752671 hasConceptScore W2078752671C39981086 @default.
- W2078752671 hasConceptScore W2078752671C40767141 @default.
- W2078752671 hasConceptScore W2078752671C54355233 @default.
- W2078752671 hasConceptScore W2078752671C70721500 @default.
- W2078752671 hasConceptScore W2078752671C84597430 @default.
- W2078752671 hasConceptScore W2078752671C86803240 @default.
- W2078752671 hasConceptScore W2078752671C92087593 @default.
- W2078752671 hasIssue "1" @default.
- W2078752671 hasLocation W20787526711 @default.
- W2078752671 hasLocation W20787526712 @default.
- W2078752671 hasOpenAccess W2078752671 @default.