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- W2078753112 endingPage "302" @default.
- W2078753112 startingPage "291" @default.
- W2078753112 abstract "Transcription is apparently risky business. Its intrinsic mutagenic potential must be kept in check by networks of DNA repair factors that monitor the transcription process to repair DNA lesions that could otherwise compromise transcriptional fidelity and genome integrity. Intriguingly, recent studies point to an even more direct function of DNA repair complexes as coactivators of transcription and the unexpected role of “scheduled” DNA damage/repair at gene promoters. Paradoxically, spontaneous DNA double-strand breaks also induce ectopic transcription that is essential for repair. Thus, transcription, DNA damage, and repair may be more physically and functionally intertwined than previously appreciated. Transcription is apparently risky business. Its intrinsic mutagenic potential must be kept in check by networks of DNA repair factors that monitor the transcription process to repair DNA lesions that could otherwise compromise transcriptional fidelity and genome integrity. Intriguingly, recent studies point to an even more direct function of DNA repair complexes as coactivators of transcription and the unexpected role of “scheduled” DNA damage/repair at gene promoters. Paradoxically, spontaneous DNA double-strand breaks also induce ectopic transcription that is essential for repair. Thus, transcription, DNA damage, and repair may be more physically and functionally intertwined than previously appreciated." @default.
- W2078753112 created "2016-06-24" @default.
- W2078753112 creator A5007556906 @default.
- W2078753112 creator A5026304050 @default.
- W2078753112 creator A5082330841 @default.
- W2078753112 date "2013-11-01" @default.
- W2078753112 modified "2023-09-29" @default.
- W2078753112 title "The Intertwined Roles of Transcription and Repair Proteins" @default.
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