Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078753583> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2078753583 endingPage "392" @default.
- W2078753583 startingPage "388" @default.
- W2078753583 abstract "Extracts from Neisseria meningitidis and N. gonorrhoeae with varying susceptibility to sulfanilamide have been investigated for dihydropteroate synthetase activity. Sulfanilamide was a competitive inhibitor of dihydropteroate synthetase with respect to p -aminobenzoate in extracts from both species. Though the K m for p -aminobenzoate was unaffected, the K i for sulfanilamide increased and the V max decreased as the strains' resistance to sulfanilamide increased. Temperature studies have revealed differences in the dihydropteroate synthetase from N. meningitidis and N. gonorrhoeae . A direct relationship was observed between the minimal inhibitory concentration of sulfanilamide determined in vitro and the ratio of K i /K m . This ratio may be a molecular explanation of sulfanilamide resistance for both N. meningitidis and N. gonorrhoeae ." @default.
- W2078753583 created "2016-06-24" @default.
- W2078753583 creator A5020672087 @default.
- W2078753583 creator A5052381679 @default.
- W2078753583 creator A5055076068 @default.
- W2078753583 creator A5057077191 @default.
- W2078753583 date "1974-04-01" @default.
- W2078753583 modified "2023-10-03" @default.
- W2078753583 title "Alterations in Dihydropteroate Synthetase in Cell-Free Extracts of Sulfanilamide-Resistant <i>Neisseria meningitidis</i> and <i>Neisseria gonorrhoeae</i>" @default.
- W2078753583 cites W1572778897 @default.
- W2078753583 cites W1775749144 @default.
- W2078753583 cites W1813415646 @default.
- W2078753583 cites W1931912635 @default.
- W2078753583 cites W193909774 @default.
- W2078753583 cites W1988175612 @default.
- W2078753583 cites W1999485221 @default.
- W2078753583 cites W2025233807 @default.
- W2078753583 cites W2034005237 @default.
- W2078753583 cites W2054486445 @default.
- W2078753583 cites W2055126516 @default.
- W2078753583 cites W2056847542 @default.
- W2078753583 cites W205937849 @default.
- W2078753583 cites W2066843354 @default.
- W2078753583 cites W2089477879 @default.
- W2078753583 doi "https://doi.org/10.1128/aac.5.4.388" @default.
- W2078753583 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/428980" @default.
- W2078753583 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15825393" @default.
- W2078753583 hasPublicationYear "1974" @default.
- W2078753583 type Work @default.
- W2078753583 sameAs 2078753583 @default.
- W2078753583 citedByCount "15" @default.
- W2078753583 crossrefType "journal-article" @default.
- W2078753583 hasAuthorship W2078753583A5020672087 @default.
- W2078753583 hasAuthorship W2078753583A5052381679 @default.
- W2078753583 hasAuthorship W2078753583A5055076068 @default.
- W2078753583 hasAuthorship W2078753583A5057077191 @default.
- W2078753583 hasBestOaLocation W20787535832 @default.
- W2078753583 hasConcept C159047783 @default.
- W2078753583 hasConcept C203014093 @default.
- W2078753583 hasConcept C2776983828 @default.
- W2078753583 hasConcept C2777035104 @default.
- W2078753583 hasConcept C2777234095 @default.
- W2078753583 hasConcept C2777425658 @default.
- W2078753583 hasConcept C2778048844 @default.
- W2078753583 hasConcept C2778458888 @default.
- W2078753583 hasConcept C2779056493 @default.
- W2078753583 hasConcept C2779166590 @default.
- W2078753583 hasConcept C501593827 @default.
- W2078753583 hasConcept C523546767 @default.
- W2078753583 hasConcept C54355233 @default.
- W2078753583 hasConcept C55493867 @default.
- W2078753583 hasConcept C86803240 @default.
- W2078753583 hasConcept C89423630 @default.
- W2078753583 hasConceptScore W2078753583C159047783 @default.
- W2078753583 hasConceptScore W2078753583C203014093 @default.
- W2078753583 hasConceptScore W2078753583C2776983828 @default.
- W2078753583 hasConceptScore W2078753583C2777035104 @default.
- W2078753583 hasConceptScore W2078753583C2777234095 @default.
- W2078753583 hasConceptScore W2078753583C2777425658 @default.
- W2078753583 hasConceptScore W2078753583C2778048844 @default.
- W2078753583 hasConceptScore W2078753583C2778458888 @default.
- W2078753583 hasConceptScore W2078753583C2779056493 @default.
- W2078753583 hasConceptScore W2078753583C2779166590 @default.
- W2078753583 hasConceptScore W2078753583C501593827 @default.
- W2078753583 hasConceptScore W2078753583C523546767 @default.
- W2078753583 hasConceptScore W2078753583C54355233 @default.
- W2078753583 hasConceptScore W2078753583C55493867 @default.
- W2078753583 hasConceptScore W2078753583C86803240 @default.
- W2078753583 hasConceptScore W2078753583C89423630 @default.
- W2078753583 hasIssue "4" @default.
- W2078753583 hasLocation W20787535831 @default.
- W2078753583 hasLocation W20787535832 @default.
- W2078753583 hasLocation W20787535833 @default.
- W2078753583 hasOpenAccess W2078753583 @default.
- W2078753583 hasPrimaryLocation W20787535831 @default.
- W2078753583 hasRelatedWork W1690126054 @default.
- W2078753583 hasRelatedWork W170088627 @default.
- W2078753583 hasRelatedWork W1964472982 @default.
- W2078753583 hasRelatedWork W2062764643 @default.
- W2078753583 hasRelatedWork W2078753583 @default.
- W2078753583 hasRelatedWork W2080733462 @default.
- W2078753583 hasRelatedWork W2105599850 @default.
- W2078753583 hasRelatedWork W2109230743 @default.
- W2078753583 hasRelatedWork W2473919745 @default.
- W2078753583 hasRelatedWork W4290429034 @default.
- W2078753583 hasVolume "5" @default.
- W2078753583 isParatext "false" @default.
- W2078753583 isRetracted "false" @default.
- W2078753583 magId "2078753583" @default.
- W2078753583 workType "article" @default.