Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078753642> ?p ?o ?g. }
- W2078753642 endingPage "461" @default.
- W2078753642 startingPage "449" @default.
- W2078753642 abstract "Over the past 35 years or so, PET brain imaging has allowed powerful and unique insights into brain function under normal conditions and in disease states. Initially, as PET instrumentation continued to develop, studies were focused on brain perfusion and glucose metabolism. This permitted refinement of brain imaging for important, nononcologic clinical indications. The ability of PET to not only provide spatial localization of metabolic changes but also to accurately and consistently quantify their distribution proved valuable for applications in the clinical setting. Specifically, glucose metabolism brain imaging using (F-18) fluorodeoxyglucose continues to be invaluable for evaluating patients with intractable seizures for identifying seizure foci and operative planning. Cerebral glucose metabolism also contributes to diagnosis of neurodegenerative diseases that cause dementia. Alzheimer disease, dementia with Lewy bodies, and the several variants of frontotemporal lobar degeneration have differing typical patterns of hypometabolism. In Alzheimer disease, hypometabolism has furthermore been associated with poorer cognitive performance and ensuing cognitive and functional decline. As the field of radiochemistry evolved, novel radioligands including radiolabeled flumazenil, dopamine transporter ligands, nicotine receptor ligands, and others have allowed for further understanding of molecular changes in the brain associated with various diseases. Recently, PET brain imaging reached another milestone with the approval of (F-18) florbetapir imaging by the United States Federal Drug Administration for detection of amyloid plaque accumulation in brain, the major histopathologic hallmark of Alzheimer disease, and efforts have been made to define the clinical role of this imaging agent in the setting of the currently limited treatment options. Hopefully, this represents the first of many new radiopharmaceuticals that would allow improved diagnostic and prognostic information in these and other clinical applications, including Parkinson disease and traumatic brain injury." @default.
- W2078753642 created "2016-06-24" @default.
- W2078753642 creator A5010506491 @default.
- W2078753642 creator A5022996283 @default.
- W2078753642 date "2013-11-01" @default.
- W2078753642 modified "2023-10-11" @default.
- W2078753642 title "An Overview of PET Neuroimaging" @default.
- W2078753642 cites W1535935686 @default.
- W2078753642 cites W1559104216 @default.
- W2078753642 cites W1561072761 @default.
- W2078753642 cites W1579964801 @default.
- W2078753642 cites W1591764851 @default.
- W2078753642 cites W1605023419 @default.
- W2078753642 cites W1690218049 @default.
- W2078753642 cites W1767818491 @default.
- W2078753642 cites W1769992009 @default.
- W2078753642 cites W1901031303 @default.
- W2078753642 cites W1936079710 @default.
- W2078753642 cites W1964810688 @default.
- W2078753642 cites W1967008186 @default.
- W2078753642 cites W1967152978 @default.
- W2078753642 cites W1968048563 @default.
- W2078753642 cites W1969301568 @default.
- W2078753642 cites W1970858190 @default.
- W2078753642 cites W1970872927 @default.
- W2078753642 cites W1971216838 @default.
- W2078753642 cites W1971565607 @default.
- W2078753642 cites W1976439197 @default.
- W2078753642 cites W1977714477 @default.
- W2078753642 cites W1978115007 @default.
- W2078753642 cites W1978293111 @default.
- W2078753642 cites W1979219463 @default.
- W2078753642 cites W1980943996 @default.
- W2078753642 cites W1982559305 @default.
- W2078753642 cites W1982881439 @default.
- W2078753642 cites W1983924090 @default.
- W2078753642 cites W1986874860 @default.
- W2078753642 cites W1986903653 @default.
- W2078753642 cites W1987373100 @default.
- W2078753642 cites W1987643907 @default.
- W2078753642 cites W1988370080 @default.
- W2078753642 cites W1989771822 @default.
- W2078753642 cites W1991755871 @default.
- W2078753642 cites W1991950182 @default.
- W2078753642 cites W1997667725 @default.
- W2078753642 cites W1998480156 @default.
- W2078753642 cites W2000981300 @default.
- W2078753642 cites W2001479501 @default.
- W2078753642 cites W2002838359 @default.
- W2078753642 cites W2002962984 @default.
- W2078753642 cites W2003423221 @default.
- W2078753642 cites W2007856779 @default.
- W2078753642 cites W2009889181 @default.
- W2078753642 cites W2010393544 @default.
- W2078753642 cites W2011269223 @default.
- W2078753642 cites W2011783385 @default.
- W2078753642 cites W2014207702 @default.
- W2078753642 cites W2014847381 @default.
- W2078753642 cites W2015024516 @default.
- W2078753642 cites W2016927401 @default.
- W2078753642 cites W2017860119 @default.
- W2078753642 cites W2017900167 @default.
- W2078753642 cites W2021878441 @default.
- W2078753642 cites W2022783826 @default.
- W2078753642 cites W2024273214 @default.
- W2078753642 cites W2025124682 @default.
- W2078753642 cites W2027228825 @default.
- W2078753642 cites W2028671462 @default.
- W2078753642 cites W2028943878 @default.
- W2078753642 cites W2031903860 @default.
- W2078753642 cites W2032031314 @default.
- W2078753642 cites W2032726927 @default.
- W2078753642 cites W2034376688 @default.
- W2078753642 cites W2035809927 @default.
- W2078753642 cites W2037959172 @default.
- W2078753642 cites W2038463965 @default.
- W2078753642 cites W2041210568 @default.
- W2078753642 cites W2047154566 @default.
- W2078753642 cites W2047277548 @default.
- W2078753642 cites W2051344448 @default.
- W2078753642 cites W2055098295 @default.
- W2078753642 cites W2056384657 @default.
- W2078753642 cites W2057049846 @default.
- W2078753642 cites W2057375178 @default.
- W2078753642 cites W2059060097 @default.
- W2078753642 cites W2060523093 @default.
- W2078753642 cites W2060672748 @default.
- W2078753642 cites W2063017390 @default.
- W2078753642 cites W2063262674 @default.
- W2078753642 cites W2063749627 @default.
- W2078753642 cites W2067128590 @default.
- W2078753642 cites W2068648364 @default.
- W2078753642 cites W2070662724 @default.
- W2078753642 cites W2071156130 @default.
- W2078753642 cites W2071948754 @default.
- W2078753642 cites W2072361983 @default.
- W2078753642 cites W2078135788 @default.
- W2078753642 cites W2078245222 @default.