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- W2078754183 abstract "The potential use of 2-hydroxypropyl-β-cyclodextrin (HP-β-CyD) in the stabilization of prostaglandin E2 (PGE2) was investigated. Inclusion complexation of PGE2 with HP-β-CyD was estimated by circular dichroism spectroscopy. The effect of HP-β-CyD on the dehydration rate of PGE2 and the isomerization rate of PGA2 was examined by comparing the rate constant of PGE2 alone with that of the inclusion complex of PGE2 with HP-β-CyD in each buffered solution. The dehydration rate of PGE2 and the isomerization rate of PGA2 under acidic conditions were decreased by HP-β-CyD, while the rates under basic conditions were increased, probably due to positive catalytic effects on the reactions. The retardation of the dehydration and isomerization rates at low pH might be the effect of inclusion complexation with HP-β-CyD." @default.
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- W2078754183 date "1994-05-01" @default.
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- W2078754183 title "Effect of 2-hydroxypropyl-β-cyclodextrin on the stability of prostaglandin E2 in solution" @default.
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- W2078754183 doi "https://doi.org/10.1016/0378-5173(94)90311-5" @default.
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