FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078754194> ?p ?o ?g. }

• W2078754194 endingPage "60" @default.
• W2078754194 startingPage "53" @default.
• W2078754194 abstract "The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a reproductive toxicant in multiple species; however, mechanisms and direct ovarian effects are poorly understood. DNA microarrays were used to characterize gene expression profiles of human luteinized granulosa cells (HLGCs) exposed to TCDD in primary cultures. Exposure to 10 nM TCDD for 24 h induced a significant increase in CYP1B1, while few other genes responded. TaqMan PCR and Western immunoblotting demonstrated that induction was dose-dependent. Additionally, the microsomal form of catechol-O-methyltransferase (COMT) was highly expressed in HLGCs, along with only fractional amounts of the soluble form. This is the first report of CYP1B1 and COMT expression, and CYP1B1 induction, in cells from the human ovary. The role of CYP1B1 in the oxidative metabolism of estrogens and potential generation of DNA adducts in the ovary may have significant consequences for oocyte quality, corpus luteum function, and ovarian carcinogenesis." @default.
• W2078754194 created "2016-06-24" @default.
• W2078754194 creator A5002562057 @default.
• W2078754194 creator A5012234184 @default.
• W2078754194 creator A5012436282 @default.
• W2078754194 creator A5079808534 @default.
• W2078754194 creator A5081503766 @default.
• W2078754194 date "2005-07-01" @default.
• W2078754194 modified "2023-10-18" @default.
• W2078754194 title "2,3,7,8-Tetrachlorodibenzo-p-dioxin induces CYP1B1 expression in human luteinized granulosa cells" @default.
• W2078754194 cites W1546668746 @default.
• W2078754194 cites W1963487709 @default.
• W2078754194 cites W1967774907 @default.
• W2078754194 cites W1968204832 @default.
• W2078754194 cites W1973922187 @default.
• W2078754194 cites W1975064171 @default.
• W2078754194 cites W1979758008 @default.
• W2078754194 cites W1988032701 @default.
• W2078754194 cites W1989235067 @default.
• W2078754194 cites W1996048503 @default.
• W2078754194 cites W2013440514 @default.
• W2078754194 cites W2021231181 @default.
• W2078754194 cites W2024851462 @default.
• W2078754194 cites W2027109773 @default.
• W2078754194 cites W2036938596 @default.
• W2078754194 cites W2051089000 @default.
• W2078754194 cites W2054286532 @default.
• W2078754194 cites W2055438858 @default.
• W2078754194 cites W2065092080 @default.
• W2078754194 cites W2079424406 @default.
• W2078754194 cites W2082547349 @default.
• W2078754194 cites W2083308172 @default.
• W2078754194 cites W2089151150 @default.
• W2078754194 cites W2092005132 @default.
• W2078754194 cites W2100403447 @default.
• W2078754194 cites W2100690704 @default.
• W2078754194 cites W2100947003 @default.
• W2078754194 cites W2115153534 @default.
• W2078754194 cites W2121492292 @default.
• W2078754194 cites W2130343048 @default.
• W2078754194 cites W2148911704 @default.
• W2078754194 cites W2150953303 @default.
• W2078754194 cites W2164575900 @default.
• W2078754194 cites W2165422066 @default.
• W2078754194 cites W2170187210 @default.
• W2078754194 cites W2170627048 @default.
• W2078754194 cites W2195080078 @default.
• W2078754194 cites W2228364734 @default.
• W2078754194 doi "https://doi.org/10.1016/j.abb.2005.04.024" @default.
• W2078754194 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15953582" @default.
• W2078754194 hasPublicationYear "2005" @default.
• W2078754194 type Work @default.
• W2078754194 sameAs 2078754194 @default.
• W2078754194 citedByCount "26" @default.
• W2078754194 countsByYear W20787541942012 @default.
• W2078754194 countsByYear W20787541942014 @default.
• W2078754194 countsByYear W20787541942015 @default.
• W2078754194 countsByYear W20787541942016 @default.
• W2078754194 countsByYear W20787541942017 @default.
• W2078754194 countsByYear W20787541942018 @default.
• W2078754194 countsByYear W20787541942019 @default.
• W2078754194 crossrefType "journal-article" @default.
• W2078754194 hasAuthorship W2078754194A5002562057 @default.
• W2078754194 hasAuthorship W2078754194A5012234184 @default.
• W2078754194 hasAuthorship W2078754194A5012436282 @default.
• W2078754194 hasAuthorship W2078754194A5079808534 @default.
• W2078754194 hasAuthorship W2078754194A5081503766 @default.
• W2078754194 hasConcept C104317684 @default.
• W2078754194 hasConcept C126322002 @default.
• W2078754194 hasConcept C134018914 @default.
• W2078754194 hasConcept C150194340 @default.
• W2078754194 hasConcept C155701950 @default.
• W2078754194 hasConcept C2776608385 @default.
• W2078754194 hasConcept C2777203538 @default.
• W2078754194 hasConcept C2778324911 @default.
• W2078754194 hasConcept C2780473477 @default.
• W2078754194 hasConcept C29730261 @default.
• W2078754194 hasConcept C33594762 @default.
• W2078754194 hasConcept C45815257 @default.
• W2078754194 hasConcept C526171541 @default.
• W2078754194 hasConcept C54355233 @default.
• W2078754194 hasConcept C62231903 @default.
• W2078754194 hasConcept C71924100 @default.
• W2078754194 hasConcept C86339819 @default.
• W2078754194 hasConcept C86803240 @default.
• W2078754194 hasConceptScore W2078754194C104317684 @default.
• W2078754194 hasConceptScore W2078754194C126322002 @default.
• W2078754194 hasConceptScore W2078754194C134018914 @default.
• W2078754194 hasConceptScore W2078754194C150194340 @default.
• W2078754194 hasConceptScore W2078754194C155701950 @default.
• W2078754194 hasConceptScore W2078754194C2776608385 @default.
• W2078754194 hasConceptScore W2078754194C2777203538 @default.
• W2078754194 hasConceptScore W2078754194C2778324911 @default.
• W2078754194 hasConceptScore W2078754194C2780473477 @default.
• W2078754194 hasConceptScore W2078754194C29730261 @default.
• W2078754194 hasConceptScore W2078754194C33594762 @default.
• W2078754194 hasConceptScore W2078754194C45815257 @default.
• W2078754194 hasConceptScore W2078754194C526171541 @default.

• next