Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078754277> ?p ?o ?g. }
- W2078754277 endingPage "295" @default.
- W2078754277 startingPage "282" @default.
- W2078754277 abstract "During development of the primary olfactory system, sensory axons project from the nasal cavity to the glomerular layer of the olfactory bulb. In the process axons can branch inappropriately into several glomeruli and sometimes over-shoot the glomerular layer, entering the deeper external plexiform layer. However in the adult, axons are rarely observed within the external plexiform layer. While chemorepulsive cues are proposed to restrict axons to the glomerular layer in the embryonic animal, these cues are clearly insufficient for all axons in the postnatal animal. We hypothesised that the external plexiform layer is initially an environment in which axons are able to grow but becomes increasingly inhibitory to axon growth in later postnatal development. We have determined that rather than having short localised trajectories as previously assumed, many axons that enter the external plexiform layer had considerable trajectories and projected preferentially along the ventro-dorsal and rostro-caudal axes for up to 950 μm. With increasing age, fewer axons were detected within the external plexiform layer but axons continued to be present until P17. Thus the external plexiform layer is initially an environment in which axons can extensively grow. We next tested whether the external plexiform layer became increasingly inhibitory to axon growth by microdissecting various layers of the olfactory bulb and preparing protein extracts. When assayed using olfactory epithelium explants of the same embryonic age, primary olfactory axons became increasingly inhibited by extract prepared from the external plexiform layer of increasingly older animals. These results demonstrate that primary olfactory axons can initially grow extensively in the external plexiform layer, but that during postnatal development inhibitory cues are upregulated that reduce axon growth within the external plexiform layer." @default.
- W2078754277 created "2016-06-24" @default.
- W2078754277 creator A5008299310 @default.
- W2078754277 creator A5011942786 @default.
- W2078754277 creator A5042087581 @default.
- W2078754277 creator A5044284698 @default.
- W2078754277 creator A5048807438 @default.
- W2078754277 creator A5062939619 @default.
- W2078754277 creator A5072375926 @default.
- W2078754277 creator A5081410662 @default.
- W2078754277 creator A5085145115 @default.
- W2078754277 creator A5090561424 @default.
- W2078754277 date "2011-01-01" @default.
- W2078754277 modified "2023-10-18" @default.
- W2078754277 title "Correction of aberrant axon growth in the developing mouse olfactory bulb" @default.
- W2078754277 cites W1501558564 @default.
- W2078754277 cites W1506689060 @default.
- W2078754277 cites W1531106880 @default.
- W2078754277 cites W1544900705 @default.
- W2078754277 cites W1567110775 @default.
- W2078754277 cites W1740677000 @default.
- W2078754277 cites W1819949295 @default.
- W2078754277 cites W1953807893 @default.
- W2078754277 cites W1969385197 @default.
- W2078754277 cites W1970256374 @default.
- W2078754277 cites W1971401377 @default.
- W2078754277 cites W1974326501 @default.
- W2078754277 cites W1978827370 @default.
- W2078754277 cites W1987452519 @default.
- W2078754277 cites W1989500792 @default.
- W2078754277 cites W1991218596 @default.
- W2078754277 cites W1996647995 @default.
- W2078754277 cites W1999224926 @default.
- W2078754277 cites W2008118471 @default.
- W2078754277 cites W2008991834 @default.
- W2078754277 cites W2020725045 @default.
- W2078754277 cites W2027727992 @default.
- W2078754277 cites W2028920013 @default.
- W2078754277 cites W2032911272 @default.
- W2078754277 cites W2033100939 @default.
- W2078754277 cites W2033937600 @default.
- W2078754277 cites W2037827891 @default.
- W2078754277 cites W2038752480 @default.
- W2078754277 cites W2041566392 @default.
- W2078754277 cites W2042902655 @default.
- W2078754277 cites W2047017001 @default.
- W2078754277 cites W2057258868 @default.
- W2078754277 cites W2059061546 @default.
- W2078754277 cites W2061737733 @default.
- W2078754277 cites W2062758517 @default.
- W2078754277 cites W2063366035 @default.
- W2078754277 cites W2064022588 @default.
- W2078754277 cites W2065274926 @default.
- W2078754277 cites W2071103277 @default.
- W2078754277 cites W2079346946 @default.
- W2078754277 cites W2083406057 @default.
- W2078754277 cites W2089193539 @default.
- W2078754277 cites W2089598622 @default.
- W2078754277 cites W2096445665 @default.
- W2078754277 cites W2101846435 @default.
- W2078754277 cites W2103275373 @default.
- W2078754277 cites W2130349147 @default.
- W2078754277 cites W2155742892 @default.
- W2078754277 cites W2156344024 @default.
- W2078754277 cites W2158953306 @default.
- W2078754277 cites W2168074899 @default.
- W2078754277 cites W2172299862 @default.
- W2078754277 doi "https://doi.org/10.1016/j.mcn.2010.09.012" @default.
- W2078754277 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20888913" @default.
- W2078754277 hasPublicationYear "2011" @default.
- W2078754277 type Work @default.
- W2078754277 sameAs 2078754277 @default.
- W2078754277 citedByCount "7" @default.
- W2078754277 countsByYear W20787542772012 @default.
- W2078754277 countsByYear W20787542772014 @default.
- W2078754277 countsByYear W20787542772017 @default.
- W2078754277 countsByYear W20787542772018 @default.
- W2078754277 countsByYear W20787542772022 @default.
- W2078754277 crossrefType "journal-article" @default.
- W2078754277 hasAuthorship W2078754277A5008299310 @default.
- W2078754277 hasAuthorship W2078754277A5011942786 @default.
- W2078754277 hasAuthorship W2078754277A5042087581 @default.
- W2078754277 hasAuthorship W2078754277A5044284698 @default.
- W2078754277 hasAuthorship W2078754277A5048807438 @default.
- W2078754277 hasAuthorship W2078754277A5062939619 @default.
- W2078754277 hasAuthorship W2078754277A5072375926 @default.
- W2078754277 hasAuthorship W2078754277A5081410662 @default.
- W2078754277 hasAuthorship W2078754277A5085145115 @default.
- W2078754277 hasAuthorship W2078754277A5090561424 @default.
- W2078754277 hasBestOaLocation W20787542772 @default.
- W2078754277 hasConcept C104317684 @default.
- W2078754277 hasConcept C105702510 @default.
- W2078754277 hasConcept C145103041 @default.
- W2078754277 hasConcept C154988683 @default.
- W2078754277 hasConcept C169760540 @default.
- W2078754277 hasConcept C201792869 @default.
- W2078754277 hasConcept C2776886281 @default.
- W2078754277 hasConcept C2779530196 @default.