FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078754671> ?p ?o ?g. }

• W2078754671 endingPage "257" @default.
• W2078754671 startingPage "244" @default.
• W2078754671 abstract "Hydrodynamic properties of fibrinogen molecules were theoretically calculated. Their shape was approximated by the bead model, considering the presence of flexible side chains of various length and orientation relative to the main body of the molecule. Using the bead model, and the precise many-multipole method of solving the Stokes equations, the mobility coefficients for the fibrinogen molecule were calculated for arbitrary orientations of the arms whose length was varied between 12 and 18 nm. Orientation averaged hydrodynamic radii and intrinsic viscosities were also calculated by considering interactions between the side arms and the core of the fibrinogen molecule. Whereas the hydrodynamic radii changed little with the interaction magnitude, the intrinsic viscosity exhibited considerable variation from 30 to 60 for attractive and repulsive interactions, respectively. These theoretical results were used for the interpretation of experimental data derived from sedimentation and diffusion coefficient measurements as well as dynamic viscosity measurements. Optimum dimensions of the fibrinogen molecule derived in this way were the following: the contour length 84.7 nm, the side arm length 18 nm, and the total volume 470 nm3, which gives 16% hydration (by volume). Our calculations enabled one to distinguish various conformational states of the fibrinogen molecule, especially the expanded conformation, prevailing for pH < 4 and lower ionic strength, characterized by high intrinsic viscosity of 50 and the hydrodynamic radius of 10.6 nm. On the other hand, for the physiological condition, that is, pH = 7.4 and the ionic strength of 0.15 M NaCl, the semi-collapsed conformation dominates. It is characterized by the average angle equal to <φ> = 55°, intrinsic viscosity of 35, and the hydrodynamic radius of 10 nm. Additionally, the interaction energy between the arms and the body of the molecule was predicted to be −4 kT units, confirming that they are oppositely charged than the central nodule. Results obtained in our work confirm an essential role of the side chains responsible for a highly anisotropic charge distribution in the fibrinogen molecule. These finding can be exploited to explain anomalous adsorption of fibrinogen on various surfaces." @default.
• W2078754671 created "2016-06-24" @default.
• W2078754671 creator A5021288224 @default.
• W2078754671 creator A5024869229 @default.
• W2078754671 creator A5028179115 @default.
• W2078754671 creator A5046279559 @default.
• W2078754671 creator A5063733434 @default.
• W2078754671 creator A5091214356 @default.
• W2078754671 date "2012-11-01" @default.
• W2078754671 modified "2023-10-03" @default.
• W2078754671 title "Fibrinogen conformations and charge in electrolyte solutions derived from DLS and dynamic viscosity measurements" @default.
• W2078754671 cites W1507424043 @default.
• W2078754671 cites W1907444416 @default.
• W2078754671 cites W1964223791 @default.
• W2078754671 cites W1965960407 @default.
• W2078754671 cites W1966049316 @default.
• W2078754671 cites W1966352369 @default.
• W2078754671 cites W1968056160 @default.
• W2078754671 cites W1968066759 @default.
• W2078754671 cites W1972353715 @default.
• W2078754671 cites W1976920225 @default.
• W2078754671 cites W1985699376 @default.
• W2078754671 cites W1988585128 @default.
• W2078754671 cites W2000862473 @default.
• W2078754671 cites W2001106116 @default.
• W2078754671 cites W2009100337 @default.
• W2078754671 cites W2011451395 @default.
• W2078754671 cites W2011538418 @default.
• W2078754671 cites W2016226468 @default.
• W2078754671 cites W2017381471 @default.
• W2078754671 cites W2019888372 @default.
• W2078754671 cites W2022451264 @default.
• W2078754671 cites W2025561491 @default.
• W2078754671 cites W2044075417 @default.
• W2078754671 cites W2046058559 @default.
• W2078754671 cites W2046378169 @default.
• W2078754671 cites W2053159898 @default.
• W2078754671 cites W2055721931 @default.
• W2078754671 cites W2064724563 @default.
• W2078754671 cites W2065957897 @default.
• W2078754671 cites W2067230558 @default.
• W2078754671 cites W2072168579 @default.
• W2078754671 cites W2075207766 @default.
• W2078754671 cites W2078132464 @default.
• W2078754671 cites W2079573450 @default.
• W2078754671 cites W2083990481 @default.
• W2078754671 cites W2135846300 @default.
• W2078754671 cites W2143444693 @default.
• W2078754671 cites W2153389625 @default.
• W2078754671 cites W2154775342 @default.
• W2078754671 cites W2158180504 @default.
• W2078754671 cites W2160124075 @default.
• W2078754671 cites W2170125941 @default.
• W2078754671 cites W2317957992 @default.
• W2078754671 cites W2321719068 @default.
• W2078754671 cites W3104468387 @default.
• W2078754671 cites W4324262994 @default.
• W2078754671 cites W48900529 @default.
• W2078754671 doi "https://doi.org/10.1016/j.jcis.2012.07.010" @default.
• W2078754671 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22883236" @default.
• W2078754671 hasPublicationYear "2012" @default.
• W2078754671 type Work @default.
• W2078754671 sameAs 2078754671 @default.
• W2078754671 citedByCount "59" @default.
• W2078754671 countsByYear W20787546712013 @default.
• W2078754671 countsByYear W20787546712014 @default.
• W2078754671 countsByYear W20787546712015 @default.
• W2078754671 countsByYear W20787546712016 @default.
• W2078754671 countsByYear W20787546712017 @default.
• W2078754671 countsByYear W20787546712018 @default.
• W2078754671 countsByYear W20787546712019 @default.
• W2078754671 countsByYear W20787546712020 @default.
• W2078754671 countsByYear W20787546712021 @default.
• W2078754671 countsByYear W20787546712022 @default.
• W2078754671 countsByYear W20787546712023 @default.
• W2078754671 crossrefType "journal-article" @default.
• W2078754671 hasAuthorship W2078754671A5021288224 @default.
• W2078754671 hasAuthorship W2078754671A5024869229 @default.
• W2078754671 hasAuthorship W2078754671A5028179115 @default.
• W2078754671 hasAuthorship W2078754671A5046279559 @default.
• W2078754671 hasAuthorship W2078754671A5063733434 @default.
• W2078754671 hasAuthorship W2078754671A5091214356 @default.
• W2078754671 hasConcept C11268172 @default.
• W2078754671 hasConcept C121332964 @default.
• W2078754671 hasConcept C127172972 @default.
• W2078754671 hasConcept C132233512 @default.
• W2078754671 hasConcept C147789679 @default.
• W2078754671 hasConcept C159467904 @default.
• W2078754671 hasConcept C17525397 @default.
• W2078754671 hasConcept C178635117 @default.
• W2078754671 hasConcept C178790620 @default.
• W2078754671 hasConcept C184651966 @default.
• W2078754671 hasConcept C185592680 @default.
• W2078754671 hasConcept C187428577 @default.
• W2078754671 hasConcept C207374878 @default.
• W2078754671 hasConcept C26360006 @default.
• W2078754671 hasConcept C32909587 @default.
• W2078754671 hasConcept C38652104 @default.

• next