FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078755921> ?p ?o ?g. }

• W2078755921 endingPage "145" @default.
• W2078755921 startingPage "127" @default.
• W2078755921 abstract "1. The developmental expression of an inwardly rectifying current activated by membrane hyperpolarization (Ih) and of a tetrodotoxin (TTX)-resistant Na+ current (INa(TR)) was studied using freshly dissociated ganglionic quail neurones of various embryonic ages. This work was carried out on parasympathetic (ciliary) and sensory (trigeminal and dorsal root) ganglion neurones with the whole-cell configuration of the patch-clamp technique. 2. In sensory and parasympathetic neurones, Ih was activated at potentials more negative than -60 mV and displayed strong inward rectification. No sign of time- or voltage-dependent inactivation was apparent. Ih was carried by both Na+ and K+ ions and was selectively and reversibly blocked by extracellular Cs+. 3. During the development of sensory neurones, Ih was observed for the first time between embryonic day 10 (E10) and E11 and the percentage of neurones expressing the current increased subsequently, reaching a plateau level of about 80% at E14. In the parasympathetic neurones of the ciliary ganglion, Ih was already detected at E10 and the percentage of neurones possessing the current increased until E16, a stage at which all neurones were found to express Ih. 4. In the presence of TTX (1 microM), an inward Na+ current, INa(TR), was recorded in sensory neurones after E12. This current was activated at potentials more depolarized than -30 mV and its amplitude was maximal at +5 mV. INa(TR) showed time- and voltage-dependent inactivation. Half-maximal steady-state inactivation was observed at -40 mV. 5. INa(TR) was observed for the first time after E12 in sensory neurones and the percentage of neurones with INa(TR) increased until E14. Thereafter, 80% of the neurones had the current. In contrast, INa(TR) was never observed in the parasympathetic neurones of the ciliary ganglion during embryonic development. 6. Our results with parasympathetic and sensory neurones suggest that the expression of INa(TR) is linked to the phenotype and not to the embryonic origin of a neurone." @default.
• W2078755921 created "2016-06-24" @default.
• W2078755921 creator A5014863610 @default.
• W2078755921 creator A5054708530 @default.
• W2078755921 creator A5072760094 @default.
• W2078755921 date "1991-10-01" @default.
• W2078755921 modified "2023-10-18" @default.
• W2078755921 title "Development of anomalous rectification (Ih) and of a tetrodotoxin-resistant sodium current in embryonic quail neurones." @default.
• W2078755921 cites W1250038976 @default.
• W2078755921 cites W1486605623 @default.
• W2078755921 cites W1491900501 @default.
• W2078755921 cites W1578677172 @default.
• W2078755921 cites W1603200478 @default.
• W2078755921 cites W1774317629 @default.
• W2078755921 cites W1813275637 @default.
• W2078755921 cites W1947078330 @default.
• W2078755921 cites W1963637213 @default.
• W2078755921 cites W1966936758 @default.
• W2078755921 cites W1976070297 @default.
• W2078755921 cites W1977253798 @default.
• W2078755921 cites W1978467401 @default.
• W2078755921 cites W1985607901 @default.
• W2078755921 cites W1993164873 @default.
• W2078755921 cites W1996438246 @default.
• W2078755921 cites W1997511216 @default.
• W2078755921 cites W2009667219 @default.
• W2078755921 cites W2011740813 @default.
• W2078755921 cites W2015426350 @default.
• W2078755921 cites W2027206867 @default.
• W2078755921 cites W2032215399 @default.
• W2078755921 cites W2036889994 @default.
• W2078755921 cites W2044137205 @default.
• W2078755921 cites W2047584122 @default.
• W2078755921 cites W2050967951 @default.
• W2078755921 cites W2055185962 @default.
• W2078755921 cites W2056644765 @default.
• W2078755921 cites W2058014139 @default.
• W2078755921 cites W2069387230 @default.
• W2078755921 cites W2070390515 @default.
• W2078755921 cites W2072043893 @default.
• W2078755921 cites W2078697776 @default.
• W2078755921 cites W2082771451 @default.
• W2078755921 cites W2085628194 @default.
• W2078755921 cites W2088323064 @default.
• W2078755921 cites W2088840944 @default.
• W2078755921 cites W2098766226 @default.
• W2078755921 cites W2112796297 @default.
• W2078755921 cites W2117531417 @default.
• W2078755921 cites W2128675443 @default.
• W2078755921 cites W2133267068 @default.
• W2078755921 cites W2149879881 @default.
• W2078755921 cites W2252378079 @default.
• W2078755921 cites W2396235587 @default.
• W2078755921 cites W2404561157 @default.
• W2078755921 cites W2406620982 @default.
• W2078755921 cites W2422573186 @default.
• W2078755921 doi "https://doi.org/10.1113/jphysiol.1991.sp018786" @default.
• W2078755921 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1179882" @default.
• W2078755921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1798027" @default.
• W2078755921 hasPublicationYear "1991" @default.
• W2078755921 type Work @default.
• W2078755921 sameAs 2078755921 @default.
• W2078755921 citedByCount "21" @default.
• W2078755921 countsByYear W20787559212015 @default.
• W2078755921 countsByYear W20787559212017 @default.
• W2078755921 crossrefType "journal-article" @default.
• W2078755921 hasAuthorship W2078755921A5014863610 @default.
• W2078755921 hasAuthorship W2078755921A5054708530 @default.
• W2078755921 hasAuthorship W2078755921A5072760094 @default.
• W2078755921 hasBestOaLocation W20787559211 @default.
• W2078755921 hasConcept C105702510 @default.
• W2078755921 hasConcept C12554922 @default.
• W2078755921 hasConcept C126322002 @default.
• W2078755921 hasConcept C131453863 @default.
• W2078755921 hasConcept C134018914 @default.
• W2078755921 hasConcept C147944092 @default.
• W2078755921 hasConcept C169760540 @default.
• W2078755921 hasConcept C178790620 @default.
• W2078755921 hasConcept C185263204 @default.
• W2078755921 hasConcept C185592680 @default.
• W2078755921 hasConcept C2775908076 @default.
• W2078755921 hasConcept C2776281502 @default.
• W2078755921 hasConcept C2776741303 @default.
• W2078755921 hasConcept C2777882087 @default.
• W2078755921 hasConcept C2779229579 @default.
• W2078755921 hasConcept C66974803 @default.
• W2078755921 hasConcept C71924100 @default.
• W2078755921 hasConcept C86803240 @default.
• W2078755921 hasConcept C94487597 @default.
• W2078755921 hasConceptScore W2078755921C105702510 @default.
• W2078755921 hasConceptScore W2078755921C12554922 @default.
• W2078755921 hasConceptScore W2078755921C126322002 @default.
• W2078755921 hasConceptScore W2078755921C131453863 @default.
• W2078755921 hasConceptScore W2078755921C134018914 @default.
• W2078755921 hasConceptScore W2078755921C147944092 @default.
• W2078755921 hasConceptScore W2078755921C169760540 @default.
• W2078755921 hasConceptScore W2078755921C178790620 @default.
• W2078755921 hasConceptScore W2078755921C185263204 @default.

• next