FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078757557> ?p ?o ?g. }

• W2078757557 abstract "The Oncotype DX Colon Cancer Assay is a new diagnostic test for determining the likelihood of recurrence in stage II colon cancer patients after surgical resection using fixed paraffin embedded (FPE) primary colon tumor tissue. Like the Oncotype DX Breast Cancer Assay, this is a high complexity, multi-analyte, reverse transcription (RT) polymerase chain reaction (PCR) assay that measures the expression levels of specific cancer-related genes. By capturing the biology underlying each patient's tumor, the Oncotype DX Colon Cancer Assay provides a Recurrence Score (RS) that reflects an individualized risk of disease recurrence. Here we describe its analytical performance using pre-determined performance criteria, which is a critical component of molecular diagnostic test validation.All analytical measurements met pre-specified performance criteria. PCR amplification efficiency for all 12 assays was high, ranging from 96% to 107%, while linearity was demonstrated over an 11 log2 concentration range for all assays. Based on estimated components of variance for FPE RNA pools, analytical reproducibility and precision demonstrated low SDs for individual genes (0.16 to 0.32 CTs), gene groups (≤ 0.05 normalized/aggregate CTs) and RS (≤ 1.38 RS units).Analytical performance characteristics shown here for both individual genes and gene groups in the Oncotype DX Colon Cancer Assay demonstrate consistent translation of specific biology of individual tumors into clinically useful diagnostic information. The results of these studies illustrate how the analytical capability of the Oncotype DX Colon Cancer Assay has enabled clinical validation of a test to determine individualized recurrence risk after colon cancer surgery." @default.
• W2078757557 created "2016-06-24" @default.
• W2078757557 creator A5002755675 @default.
• W2078757557 creator A5056629892 @default.
• W2078757557 creator A5063335511 @default.
• W2078757557 creator A5073553571 @default.
• W2078757557 date "2010-12-01" @default.
• W2078757557 modified "2023-10-17" @default.
• W2078757557 title "Translating tumor biology into personalized treatment planning: analytical performance characteristics of the Oncotype DX®Colon Cancer Assay" @default.
• W2078757557 cites W1484414601 @default.
• W2078757557 cites W1920378002 @default.
• W2078757557 cites W1989653345 @default.
• W2078757557 cites W1992608045 @default.
• W2078757557 cites W2000264668 @default.
• W2078757557 cites W2003278673 @default.
• W2078757557 cites W2004140222 @default.
• W2078757557 cites W2009629116 @default.
• W2078757557 cites W2010637767 @default.
• W2078757557 cites W2012124753 @default.
• W2078757557 cites W2012239746 @default.
• W2078757557 cites W2022038525 @default.
• W2078757557 cites W2032930680 @default.
• W2078757557 cites W2058043554 @default.
• W2078757557 cites W2061322694 @default.
• W2078757557 cites W2061723075 @default.
• W2078757557 cites W2062809449 @default.
• W2078757557 cites W2065258600 @default.
• W2078757557 cites W2066745712 @default.
• W2078757557 cites W2080480789 @default.
• W2078757557 cites W2093531978 @default.
• W2078757557 cites W2093909277 @default.
• W2078757557 cites W2095860099 @default.
• W2078757557 cites W2105337907 @default.
• W2078757557 cites W2105882193 @default.
• W2078757557 cites W2106811951 @default.
• W2078757557 cites W2108244474 @default.
• W2078757557 cites W2111725473 @default.
• W2078757557 cites W2117305280 @default.
• W2078757557 cites W2123820544 @default.
• W2078757557 cites W2124402963 @default.
• W2078757557 cites W2129859749 @default.
• W2078757557 cites W2134435289 @default.
• W2078757557 cites W2151798039 @default.
• W2078757557 cites W2154976095 @default.
• W2078757557 cites W2156711378 @default.
• W2078757557 cites W2157173581 @default.
• W2078757557 cites W2159084559 @default.
• W2078757557 cites W2160377567 @default.
• W2078757557 cites W2167290154 @default.
• W2078757557 cites W2171974881 @default.
• W2078757557 cites W2314203153 @default.
• W2078757557 cites W2333367268 @default.
• W2078757557 cites W41523064 @default.
• W2078757557 doi "https://doi.org/10.1186/1471-2407-10-691" @default.
• W2078757557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3016296" @default.
• W2078757557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21176237" @default.
• W2078757557 hasPublicationYear "2010" @default.
• W2078757557 type Work @default.
• W2078757557 sameAs 2078757557 @default.
• W2078757557 citedByCount "87" @default.
• W2078757557 countsByYear W20787575572012 @default.
• W2078757557 countsByYear W20787575572013 @default.
• W2078757557 countsByYear W20787575572014 @default.
• W2078757557 countsByYear W20787575572015 @default.
• W2078757557 countsByYear W20787575572016 @default.
• W2078757557 countsByYear W20787575572017 @default.
• W2078757557 countsByYear W20787575572018 @default.
• W2078757557 countsByYear W20787575572019 @default.
• W2078757557 countsByYear W20787575572020 @default.
• W2078757557 countsByYear W20787575572021 @default.
• W2078757557 countsByYear W20787575572022 @default.
• W2078757557 countsByYear W20787575572023 @default.
• W2078757557 crossrefType "journal-article" @default.
• W2078757557 hasAuthorship W2078757557A5002755675 @default.
• W2078757557 hasAuthorship W2078757557A5056629892 @default.
• W2078757557 hasAuthorship W2078757557A5063335511 @default.
• W2078757557 hasAuthorship W2078757557A5073553571 @default.
• W2078757557 hasBestOaLocation W20787575571 @default.
• W2078757557 hasConcept C104317684 @default.
• W2078757557 hasConcept C121608353 @default.
• W2078757557 hasConcept C126322002 @default.
• W2078757557 hasConcept C143998085 @default.
• W2078757557 hasConcept C2779134260 @default.
• W2078757557 hasConcept C2780140570 @default.
• W2078757557 hasConcept C48023723 @default.
• W2078757557 hasConcept C526805850 @default.
• W2078757557 hasConcept C530470458 @default.
• W2078757557 hasConcept C55493867 @default.
• W2078757557 hasConcept C60644358 @default.
• W2078757557 hasConcept C71924100 @default.
• W2078757557 hasConcept C86803240 @default.
• W2078757557 hasConceptScore W2078757557C104317684 @default.
• W2078757557 hasConceptScore W2078757557C121608353 @default.
• W2078757557 hasConceptScore W2078757557C126322002 @default.
• W2078757557 hasConceptScore W2078757557C143998085 @default.
• W2078757557 hasConceptScore W2078757557C2779134260 @default.
• W2078757557 hasConceptScore W2078757557C2780140570 @default.
• W2078757557 hasConceptScore W2078757557C48023723 @default.
• W2078757557 hasConceptScore W2078757557C526805850 @default.
• W2078757557 hasConceptScore W2078757557C530470458 @default.

• next