FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078757921> ?p ?o ?g. }

• W2078757921 endingPage "278" @default.
• W2078757921 startingPage "269" @default.
• W2078757921 abstract "The antiarrhythmic effects of vehicle (0.1% dimethyl sulfoxide: DMSO) or capsaicin were evaluated in isolated perfused rat and guinea pig heart preparations. In the rat, capsaicin reduced ischemic ventricular tachycardia from 100% in control to 0%, and ischemic ventricular fibrillation from 60% in control to 0% at 30 μM, and diltiazem reduced the incidence of ischemic ventricular tachycardia and ventricular fibrillation to 55% and 0%, respectively. Reperfusion ventricular fibrillation was reduced from 90% to 20% and 33% for capsaicin and diltiazem, respectively, at these concentrations. In isolated perfused globally ischemic rat hearts, antiischemic efficacy was assessed as a significant extension (36% and 50%) in time to contracture with 30 μM capsaicin and 1 μM diltiazem, respectively. Capsaicin reduced left ventricular developed pressure by 35% in non-ischemic rat hearts, and increased coronary flow by 40%. The increased time to contracture for either compound was not blocked by glyburide (0.1 μM) suggesting a lack of any involvement of ATP-sensitive K+ channels. In isolated guinea pig hearts subjected to global ischemia, capsaicin and diltiazem reduced reperfusion ventricular fibrillation from 100% to 10% and 0% at 30 and 3 μM, respectively. Electrophysiologic evaluation in guinea pig papillary muscles using standard microelectrode techniques demonstrated significant (P < 0.05) action potential durations at 90% repolarization shortening at 1 Hz by 9%, 28% and 39%, and 23%, 37% and 51% at 10, 30, and 100 μM of capsaicin or diltiazem, respectively. Unlike diltiazem, no changes in action potential duration were observed with capsaicin (up to 100 μM) at faster stimulation rates (5 Hz). In conclusion, capsaicin displays both antiarrhythmic and antiischemic efficacy. These data suggest that the effects of capsaicin are mediated primarily through block of Ca2+ channels in these preparations." @default.
• W2078757921 created "2016-06-24" @default.
• W2078757921 creator A5002195234 @default.
• W2078757921 creator A5005893592 @default.
• W2078757921 creator A5009301588 @default.
• W2078757921 creator A5030379197 @default.
• W2078757921 creator A5038928807 @default.
• W2078757921 creator A5049166062 @default.
• W2078757921 creator A5060302237 @default.
• W2078757921 creator A5072999477 @default.
• W2078757921 date "1995-01-01" @default.
• W2078757921 modified "2023-10-18" @default.
• W2078757921 title "In vitro effects of capsaicin: antiarrhythmic and antiischemic activity" @default.
• W2078757921 cites W1561915708 @default.
• W2078757921 cites W1967151871 @default.
• W2078757921 cites W1968230648 @default.
• W2078757921 cites W1975869151 @default.
• W2078757921 cites W1981699410 @default.
• W2078757921 cites W2002153297 @default.
• W2078757921 cites W2007448071 @default.
• W2078757921 cites W2011653324 @default.
• W2078757921 cites W2017794006 @default.
• W2078757921 cites W2023318104 @default.
• W2078757921 cites W2028179937 @default.
• W2078757921 cites W2046723038 @default.
• W2078757921 cites W2048979764 @default.
• W2078757921 cites W2066461253 @default.
• W2078757921 cites W2071293796 @default.
• W2078757921 cites W2078400840 @default.
• W2078757921 cites W2091967055 @default.
• W2078757921 cites W2109817588 @default.
• W2078757921 cites W2113895167 @default.
• W2078757921 cites W2116056374 @default.
• W2078757921 cites W2121614682 @default.
• W2078757921 cites W2135225379 @default.
• W2078757921 cites W2149462844 @default.
• W2078757921 cites W2153936909 @default.
• W2078757921 cites W2168806904 @default.
• W2078757921 doi "https://doi.org/10.1016/0014-2999(94)00653-o" @default.
• W2078757921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7713171" @default.
• W2078757921 hasPublicationYear "1995" @default.
• W2078757921 type Work @default.
• W2078757921 sameAs 2078757921 @default.
• W2078757921 citedByCount "48" @default.
• W2078757921 countsByYear W20787579212012 @default.
• W2078757921 countsByYear W20787579212013 @default.
• W2078757921 countsByYear W20787579212014 @default.
• W2078757921 countsByYear W20787579212015 @default.
• W2078757921 countsByYear W20787579212016 @default.
• W2078757921 countsByYear W20787579212017 @default.
• W2078757921 countsByYear W20787579212018 @default.
• W2078757921 countsByYear W20787579212019 @default.
• W2078757921 countsByYear W20787579212020 @default.
• W2078757921 countsByYear W20787579212021 @default.
• W2078757921 countsByYear W20787579212022 @default.
• W2078757921 countsByYear W20787579212023 @default.
• W2078757921 crossrefType "journal-article" @default.
• W2078757921 hasAuthorship W2078757921A5002195234 @default.
• W2078757921 hasAuthorship W2078757921A5005893592 @default.
• W2078757921 hasAuthorship W2078757921A5009301588 @default.
• W2078757921 hasAuthorship W2078757921A5030379197 @default.
• W2078757921 hasAuthorship W2078757921A5038928807 @default.
• W2078757921 hasAuthorship W2078757921A5049166062 @default.
• W2078757921 hasAuthorship W2078757921A5060302237 @default.
• W2078757921 hasAuthorship W2078757921A5072999477 @default.
• W2078757921 hasConcept C126322002 @default.
• W2078757921 hasConcept C146403970 @default.
• W2078757921 hasConcept C164705383 @default.
• W2078757921 hasConcept C170493617 @default.
• W2078757921 hasConcept C185263204 @default.
• W2078757921 hasConcept C2776331378 @default.
• W2078757921 hasConcept C2776741139 @default.
• W2078757921 hasConcept C2777274916 @default.
• W2078757921 hasConcept C2777356233 @default.
• W2078757921 hasConcept C2778131192 @default.
• W2078757921 hasConcept C2779161974 @default.
• W2078757921 hasConcept C2780051329 @default.
• W2078757921 hasConcept C2780074459 @default.
• W2078757921 hasConcept C2781005686 @default.
• W2078757921 hasConcept C42219234 @default.
• W2078757921 hasConcept C519063684 @default.
• W2078757921 hasConcept C541997718 @default.
• W2078757921 hasConcept C71924100 @default.
• W2078757921 hasConcept C98274493 @default.
• W2078757921 hasConceptScore W2078757921C126322002 @default.
• W2078757921 hasConceptScore W2078757921C146403970 @default.
• W2078757921 hasConceptScore W2078757921C164705383 @default.
• W2078757921 hasConceptScore W2078757921C170493617 @default.
• W2078757921 hasConceptScore W2078757921C185263204 @default.
• W2078757921 hasConceptScore W2078757921C2776331378 @default.
• W2078757921 hasConceptScore W2078757921C2776741139 @default.
• W2078757921 hasConceptScore W2078757921C2777274916 @default.
• W2078757921 hasConceptScore W2078757921C2777356233 @default.
• W2078757921 hasConceptScore W2078757921C2778131192 @default.
• W2078757921 hasConceptScore W2078757921C2779161974 @default.
• W2078757921 hasConceptScore W2078757921C2780051329 @default.
• W2078757921 hasConceptScore W2078757921C2780074459 @default.
• W2078757921 hasConceptScore W2078757921C2781005686 @default.

• next