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- W2078760188 startingPage "301" @default.
- W2078760188 abstract "The immunoglobulin superfamily molecule protein zero (P0) is important for myelin formation and may also play a role in adult axon regeneration, since it promotes neurite outgrowth in vitro. Moreover, it is expressed in the regenerating central nervous system (CNS) of fish, but not in the nonregenerating CNS of mammals. We identified a P0 homolog in zebrafish. Cell type-specific expression of P0 begins in the ventromedial hindbrain and the optic chiasm at 3-5 days of development. Later (at 4 weeks) expression has spread throughout the optic system and spinal cord. This is consistent with a role for P0 in CNS myelination during development. In the adult CNS, glial cells constitutively express P0 mRNA. After an optic nerve crush, expression is increased within 2 days in the entire optic pathway. Expression peaks at 1 to 2 months and remains elevated for at least 6 months postlesion. After enucleation, P0 mRNA expression is also upregulated but fails to reach the high levels observed in crush-lesioned animals at 4 weeks postlesion. Spinal cord transection leads to increased expression of P0 mRNA in the spinal cord caudal to the lesion site. The glial upregulation of P0 mRNA expression after a lesion of the adult zebrafish CNS suggests roles for P0 in promoting axon regeneration and remyelination after injury." @default.
- W2078760188 created "2016-06-24" @default.
- W2078760188 creator A5004973809 @default.
- W2078760188 creator A5081370735 @default.
- W2078760188 creator A5081747194 @default.
- W2078760188 creator A5088526865 @default.
- W2078760188 date "2003-01-13" @default.
- W2078760188 modified "2023-09-26" @default.
- W2078760188 title "Expression of protein zero is increased in lesioned axon pathways in the central nervous system of adult zebrafish" @default.
- W2078760188 cites W118890540 @default.
- W2078760188 cites W1518325536 @default.
- W2078760188 cites W1557598012 @default.
- W2078760188 cites W1566509581 @default.
- W2078760188 cites W1586855301 @default.
- W2078760188 cites W1601004977 @default.
- W2078760188 cites W1626699932 @default.
- W2078760188 cites W1675393486 @default.
- W2078760188 cites W1827800528 @default.
- W2078760188 cites W1920404482 @default.
- W2078760188 cites W1952053031 @default.
- W2078760188 cites W1955437910 @default.
- W2078760188 cites W1965304162 @default.
- W2078760188 cites W1967078733 @default.
- W2078760188 cites W1971281441 @default.
- W2078760188 cites W1971320724 @default.
- W2078760188 cites W1971717180 @default.
- W2078760188 cites W1973283250 @default.
- W2078760188 cites W1975899886 @default.
- W2078760188 cites W1978121032 @default.
- W2078760188 cites W1979702979 @default.
- W2078760188 cites W1980771298 @default.
- W2078760188 cites W1982327997 @default.
- W2078760188 cites W1984509666 @default.
- W2078760188 cites W1985354097 @default.
- W2078760188 cites W1985432034 @default.
- W2078760188 cites W1987467814 @default.
- W2078760188 cites W1991578536 @default.
- W2078760188 cites W1992001038 @default.
- W2078760188 cites W1995469202 @default.
- W2078760188 cites W2003781664 @default.
- W2078760188 cites W2004207364 @default.
- W2078760188 cites W2004339764 @default.
- W2078760188 cites W2005416260 @default.
- W2078760188 cites W2009191172 @default.
- W2078760188 cites W2009657747 @default.
- W2078760188 cites W2009847120 @default.
- W2078760188 cites W2010124105 @default.
- W2078760188 cites W2010406663 @default.
- W2078760188 cites W2011757341 @default.
- W2078760188 cites W2012132694 @default.
- W2078760188 cites W2012928251 @default.
- W2078760188 cites W2013267369 @default.
- W2078760188 cites W2014399514 @default.
- W2078760188 cites W2015789561 @default.
- W2078760188 cites W2016319815 @default.
- W2078760188 cites W2018719279 @default.
- W2078760188 cites W2019964690 @default.
- W2078760188 cites W2020453274 @default.
- W2078760188 cites W2022844868 @default.
- W2078760188 cites W2026041941 @default.
- W2078760188 cites W2027856332 @default.
- W2078760188 cites W2029664852 @default.
- W2078760188 cites W2035340480 @default.
- W2078760188 cites W2035981357 @default.
- W2078760188 cites W2036080490 @default.
- W2078760188 cites W2036567890 @default.
- W2078760188 cites W2039791904 @default.
- W2078760188 cites W2039959415 @default.
- W2078760188 cites W2042250021 @default.
- W2078760188 cites W2049325499 @default.
- W2078760188 cites W2055043387 @default.
- W2078760188 cites W2055718798 @default.
- W2078760188 cites W2056068926 @default.
- W2078760188 cites W2058486555 @default.
- W2078760188 cites W2068179546 @default.
- W2078760188 cites W2070042427 @default.
- W2078760188 cites W2074480164 @default.
- W2078760188 cites W2077021837 @default.
- W2078760188 cites W2077370760 @default.
- W2078760188 cites W2078062494 @default.
- W2078760188 cites W2081882296 @default.
- W2078760188 cites W2085880342 @default.
- W2078760188 cites W2093229003 @default.
- W2078760188 cites W2096475309 @default.
- W2078760188 cites W2098557198 @default.
- W2078760188 cites W2100986512 @default.
- W2078760188 cites W2102323023 @default.
- W2078760188 cites W2110998704 @default.
- W2078760188 cites W2111594035 @default.
- W2078760188 cites W2112537227 @default.
- W2078760188 cites W2117097628 @default.
- W2078760188 cites W2120290397 @default.
- W2078760188 cites W2120960764 @default.
- W2078760188 cites W2124871329 @default.
- W2078760188 cites W2128178775 @default.
- W2078760188 cites W2129775648 @default.
- W2078760188 cites W2138707664 @default.
- W2078760188 cites W2152612174 @default.