Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078762085> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2078762085 endingPage "500" @default.
- W2078762085 startingPage "495" @default.
- W2078762085 abstract "Recent studies have identified the Alzheimer's disease amyloid beta/A4 protein precursor (APP) as a trophic and/or tropic protein on several types of cells, including fibroblasts, primary culture neurons, PC12 cells, and B103 neuron-like cells. Many trophic proteins bind heparin, and it is believed that the heparin-binding domain is crucial for the trophic activity of these proteins. APP also binds heparin. The current studies were undertaken to examine the hypothesis that the neuritotropic activity of APP requires heparin binding. It was found that APP produced in E. coli bound B103 cells through detergent-extractable molecules. Approximately 50% of the binding sites were heparinase-sensitive, and heparin and heparan sulfate competed for APP binding to these sites. The heparinase-insensitive sites were recognized by a stretch of 17 amino acids of APP (residues 319-335) that contains the neuritotropic activity of APP. A mutant APP with a deletion at this site was capable of binding to the heparinase-sensitive sites, although this molecule was not neuritotropic to B103 neuron-like cells. Therefore, the neuritotropic site and the heparin-binding site are distinct in APP, and the neuritotropic effect of APP is produced through its binding to detergent-extractable and heparinase-insensitive sites." @default.
- W2078762085 created "2016-06-24" @default.
- W2078762085 creator A5022477562 @default.
- W2078762085 creator A5024208611 @default.
- W2078762085 creator A5068706107 @default.
- W2078762085 creator A5073754932 @default.
- W2078762085 date "2002-11-23" @default.
- W2078762085 modified "2023-09-27" @default.
- W2078762085 title "Secreted Form of Amyloid β/A4 Protein Precursor (APP) Binds to Two Distinct APP Binding Sites on Rat B103 Neuron-Like Cells Through Two Different Domains, but Only One Site Is Involved in Neuritotropic Activity" @default.
- W2078762085 doi "https://doi.org/10.1046/j.1471-4159.1994.63020495.x" @default.
- W2078762085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7913487" @default.
- W2078762085 hasPublicationYear "2002" @default.
- W2078762085 type Work @default.
- W2078762085 sameAs 2078762085 @default.
- W2078762085 citedByCount "57" @default.
- W2078762085 countsByYear W20787620852012 @default.
- W2078762085 countsByYear W20787620852013 @default.
- W2078762085 countsByYear W20787620852014 @default.
- W2078762085 countsByYear W20787620852016 @default.
- W2078762085 countsByYear W20787620852017 @default.
- W2078762085 countsByYear W20787620852018 @default.
- W2078762085 countsByYear W20787620852019 @default.
- W2078762085 countsByYear W20787620852021 @default.
- W2078762085 countsByYear W20787620852023 @default.
- W2078762085 crossrefType "journal-article" @default.
- W2078762085 hasAuthorship W2078762085A5022477562 @default.
- W2078762085 hasAuthorship W2078762085A5024208611 @default.
- W2078762085 hasAuthorship W2078762085A5068706107 @default.
- W2078762085 hasAuthorship W2078762085A5073754932 @default.
- W2078762085 hasConcept C107824862 @default.
- W2078762085 hasConcept C126322002 @default.
- W2078762085 hasConcept C153911025 @default.
- W2078762085 hasConcept C169760540 @default.
- W2078762085 hasConcept C185592680 @default.
- W2078762085 hasConcept C2777557582 @default.
- W2078762085 hasConcept C2778041096 @default.
- W2078762085 hasConcept C2778794669 @default.
- W2078762085 hasConcept C2779134260 @default.
- W2078762085 hasConcept C31705614 @default.
- W2078762085 hasConcept C502032728 @default.
- W2078762085 hasConcept C51639874 @default.
- W2078762085 hasConcept C55493867 @default.
- W2078762085 hasConcept C71924100 @default.
- W2078762085 hasConcept C86803240 @default.
- W2078762085 hasConcept C95444343 @default.
- W2078762085 hasConceptScore W2078762085C107824862 @default.
- W2078762085 hasConceptScore W2078762085C126322002 @default.
- W2078762085 hasConceptScore W2078762085C153911025 @default.
- W2078762085 hasConceptScore W2078762085C169760540 @default.
- W2078762085 hasConceptScore W2078762085C185592680 @default.
- W2078762085 hasConceptScore W2078762085C2777557582 @default.
- W2078762085 hasConceptScore W2078762085C2778041096 @default.
- W2078762085 hasConceptScore W2078762085C2778794669 @default.
- W2078762085 hasConceptScore W2078762085C2779134260 @default.
- W2078762085 hasConceptScore W2078762085C31705614 @default.
- W2078762085 hasConceptScore W2078762085C502032728 @default.
- W2078762085 hasConceptScore W2078762085C51639874 @default.
- W2078762085 hasConceptScore W2078762085C55493867 @default.
- W2078762085 hasConceptScore W2078762085C71924100 @default.
- W2078762085 hasConceptScore W2078762085C86803240 @default.
- W2078762085 hasConceptScore W2078762085C95444343 @default.
- W2078762085 hasIssue "2" @default.
- W2078762085 hasLocation W20787620851 @default.
- W2078762085 hasLocation W20787620852 @default.
- W2078762085 hasOpenAccess W2078762085 @default.
- W2078762085 hasPrimaryLocation W20787620851 @default.
- W2078762085 hasRelatedWork W2003326907 @default.
- W2078762085 hasRelatedWork W2066346909 @default.
- W2078762085 hasRelatedWork W2071991954 @default.
- W2078762085 hasRelatedWork W2074351534 @default.
- W2078762085 hasRelatedWork W2096907533 @default.
- W2078762085 hasRelatedWork W2113288839 @default.
- W2078762085 hasRelatedWork W2138214875 @default.
- W2078762085 hasRelatedWork W2151280162 @default.
- W2078762085 hasRelatedWork W2571656945 @default.
- W2078762085 hasRelatedWork W3041474915 @default.
- W2078762085 hasVolume "63" @default.
- W2078762085 isParatext "false" @default.
- W2078762085 isRetracted "false" @default.
- W2078762085 magId "2078762085" @default.
- W2078762085 workType "article" @default.