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- W2078762947 endingPage "384" @default.
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- W2078762947 abstract "Transepithelial bicarbonate secretion plays a key role in the maintenance of fluid and protein secretion from epithelial cells and the protection of the epithelial cell surface from various pathogens. Epithelial bicarbonate secretion is mainly under the control of cAMP and calcium signaling. While the physiological roles and molecular mechanisms of cAMP-induced bicarbonate secretion are relatively well defined, those induced by calcium signaling remain poorly understood in most epithelia. The present review summarizes the current status of knowledge on the role of calcium signaling in epithelial bicarbonate secretion. Specifically, this review introduces how cytosolic calcium signaling can increase bicarbonate secretion by regulating membrane transport proteins and how it synergizes with cAMP-induced mechanisms in epithelial cells. In addition, tissue-specific variations in the pancreas, salivary glands, intestines, bile ducts, and airways are discussed. We hope that the present report will stimulate further research into this important topic. These studies will provide the basis for future medicines for a wide spectrum of epithelial disorders including cystic fibrosis, Sjögren's syndrome, and chronic pancreatitis." @default.
- W2078762947 created "2016-06-24" @default.
- W2078762947 creator A5011007448 @default.
- W2078762947 creator A5034176785 @default.
- W2078762947 date "2014-06-01" @default.
- W2078762947 modified "2023-10-14" @default.
- W2078762947 title "Role of calcium signaling in epithelial bicarbonate secretion" @default.
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