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• W2078769540 abstract "The function of inhibitory interneurons within brain microcircuits depends critically on the nature and properties of their excitatory synaptic drive. Golgi cells (GoCs) of the cerebellum inhibit cerebellar granule cells (GrCs) and are driven both by feedforward mossy fiber (<i>mf</i>) and feedback GrC excitation. Here, we have characterized GrC inputs to GoCs in rats and mice. We show that, during sustained <i>mf</i> discharge, synapses from local GrCs contribute equivalent charge to GoCs as <i>mf</i> synapses, arguing for the importance of the feedback inhibition. Previous studies predicted that GrC-GoC synapses occur predominantly between parallel fibers (<i>pf</i>s) and apical GoC dendrites in the molecular layer (ML). By combining EM and Ca²⁺ imaging, we now demonstrate the presence of functional synaptic contacts between ascending axons (<i>aa</i>) of GrCs and basolateral dendrites of GoCs in the granular layer (GL). Immunohistochemical quantification estimates these contacts to be ∼400 per GoC. Using Ca²⁺ imaging to identify synaptic inputs, we show that EPSCs from <i>aa</i> and <i>mf</i> contacts in basolateral dendrites display similarly fast kinetics, whereas <i>pf</i> inputs in the ML exhibit markedly slower kinetics as they undergo strong filtering by apical dendrites. We estimate that approximately half of the local GrC contacts generate fast EPSCs, indicating their basolateral location in the GL. We conclude that GrCs, through their <i>aa</i> contacts onto proximal GoC dendrites, define a powerful feedback inhibitory circuit in the GL." @default.
• W2078769540 created "2016-06-24" @default.
• W2078769540 creator A5005647434 @default.
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• W2078769540 date "2013-07-24" @default.
• W2078769540 modified "2023-10-12" @default.
• W2078769540 title "Granule Cell Ascending Axon Excitatory Synapses onto Golgi Cells Implement a Potent Feedback Circuit in the Cerebellar Granular Layer" @default.
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• W2078769540 doi "https://doi.org/10.1523/jneurosci.4897-11.2013" @default.
• W2078769540 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6618671" @default.
• W2078769540 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23884948" @default.

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