Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078771950> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2078771950 endingPage "50" @default.
- W2078771950 startingPage "45" @default.
- W2078771950 abstract "Recent studies have shown that transforming growth factor-beta (TGF beta) alters DNA synthesis and iodide metabolism in human, porcine, and rat thyroid cells. In the present work we studied the mechanism of TGF beta action in FRTL-5 rat thyroid cells. The cells were treated with TGF beta in the presence of TSH, growth factors, and cellular modulators for various periods of time; then, [3H]thymidine incorporation and DNA content were measured as indicators of DNA synthesis, and [125I]iodide uptake was measured to assess cell function. TGF beta (10 ng/ml) inhibited TSH-induced DNA synthesis and iodide uptake. TGF beta also inhibited DNA synthesis induced by insulin-like growth factor-I, fibroblast growth factor, and endothelial cell growth factor. The protein kinase-A (PKA) activator 8-bromo-cAMP increased both iodide uptake and DNA synthesis; TGF beta inhibited 8-bromo-cAMP-induced [125I]iodide uptake, but not [3H]thymidine incorporation. The protein kinase-C (PKC) activator phorbol 12-myristate 13-acetate increased [3H]thymidine incorporation, and TGF beta inhibited this action of phorbol 12-myristate 13-acetate. The results show that activation of PKA or PKC increases DNA synthesis. TGF beta inhibited PKC-mediated, but not PKA-mediated, DNA synthesis in these cells. The results also show that TGF beta selectively inhibits PKA-mediated iodide uptake, but not PKA-mediated DNA synthesis. These findings suggest that TGF beta is a strong inhibitor of the proliferation and function of thyroid cells." @default.
- W2078771950 created "2016-06-24" @default.
- W2078771950 creator A5029687387 @default.
- W2078771950 creator A5053739210 @default.
- W2078771950 creator A5087352271 @default.
- W2078771950 date "1992-07-01" @default.
- W2078771950 modified "2023-10-11" @default.
- W2078771950 title "Transforming growth factor-beta blocks protein kinase-A-mediated iodide transport and protein kinase-C-mediated DNA synthesis in FRTL-5 rat thyroid cells." @default.
- W2078771950 cites W1975392093 @default.
- W2078771950 cites W1996041999 @default.
- W2078771950 cites W2016167881 @default.
- W2078771950 cites W2030974372 @default.
- W2078771950 cites W2042743000 @default.
- W2078771950 cites W2073553245 @default.
- W2078771950 cites W2098692142 @default.
- W2078771950 cites W2101657207 @default.
- W2078771950 cites W2108986866 @default.
- W2078771950 cites W2113289867 @default.
- W2078771950 doi "https://doi.org/10.1210/endo.131.1.1612026" @default.
- W2078771950 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1612026" @default.
- W2078771950 hasPublicationYear "1992" @default.
- W2078771950 type Work @default.
- W2078771950 sameAs 2078771950 @default.
- W2078771950 citedByCount "37" @default.
- W2078771950 countsByYear W20787719502019 @default.
- W2078771950 countsByYear W20787719502020 @default.
- W2078771950 countsByYear W20787719502021 @default.
- W2078771950 countsByYear W20787719502023 @default.
- W2078771950 crossrefType "journal-article" @default.
- W2078771950 hasAuthorship W2078771950A5029687387 @default.
- W2078771950 hasAuthorship W2078771950A5053739210 @default.
- W2078771950 hasAuthorship W2078771950A5087352271 @default.
- W2078771950 hasConcept C118131993 @default.
- W2078771950 hasConcept C126322002 @default.
- W2078771950 hasConcept C134018914 @default.
- W2078771950 hasConcept C153911025 @default.
- W2078771950 hasConcept C170493617 @default.
- W2078771950 hasConcept C184235292 @default.
- W2078771950 hasConcept C185592680 @default.
- W2078771950 hasConcept C195794163 @default.
- W2078771950 hasConcept C2775960820 @default.
- W2078771950 hasConcept C2778229498 @default.
- W2078771950 hasConcept C2780043322 @default.
- W2078771950 hasConcept C552990157 @default.
- W2078771950 hasConcept C55493867 @default.
- W2078771950 hasConcept C62112901 @default.
- W2078771950 hasConcept C64241487 @default.
- W2078771950 hasConcept C71924100 @default.
- W2078771950 hasConcept C86803240 @default.
- W2078771950 hasConcept C88045685 @default.
- W2078771950 hasConcept C97029542 @default.
- W2078771950 hasConceptScore W2078771950C118131993 @default.
- W2078771950 hasConceptScore W2078771950C126322002 @default.
- W2078771950 hasConceptScore W2078771950C134018914 @default.
- W2078771950 hasConceptScore W2078771950C153911025 @default.
- W2078771950 hasConceptScore W2078771950C170493617 @default.
- W2078771950 hasConceptScore W2078771950C184235292 @default.
- W2078771950 hasConceptScore W2078771950C185592680 @default.
- W2078771950 hasConceptScore W2078771950C195794163 @default.
- W2078771950 hasConceptScore W2078771950C2775960820 @default.
- W2078771950 hasConceptScore W2078771950C2778229498 @default.
- W2078771950 hasConceptScore W2078771950C2780043322 @default.
- W2078771950 hasConceptScore W2078771950C552990157 @default.
- W2078771950 hasConceptScore W2078771950C55493867 @default.
- W2078771950 hasConceptScore W2078771950C62112901 @default.
- W2078771950 hasConceptScore W2078771950C64241487 @default.
- W2078771950 hasConceptScore W2078771950C71924100 @default.
- W2078771950 hasConceptScore W2078771950C86803240 @default.
- W2078771950 hasConceptScore W2078771950C88045685 @default.
- W2078771950 hasConceptScore W2078771950C97029542 @default.
- W2078771950 hasIssue "1" @default.
- W2078771950 hasLocation W20787719501 @default.
- W2078771950 hasLocation W20787719502 @default.
- W2078771950 hasOpenAccess W2078771950 @default.
- W2078771950 hasPrimaryLocation W20787719501 @default.
- W2078771950 hasRelatedWork W1968234224 @default.
- W2078771950 hasRelatedWork W1975286344 @default.
- W2078771950 hasRelatedWork W1983556646 @default.
- W2078771950 hasRelatedWork W1993329902 @default.
- W2078771950 hasRelatedWork W2002902845 @default.
- W2078771950 hasRelatedWork W2022445643 @default.
- W2078771950 hasRelatedWork W2026913891 @default.
- W2078771950 hasRelatedWork W2029870587 @default.
- W2078771950 hasRelatedWork W2084059091 @default.
- W2078771950 hasRelatedWork W2086524221 @default.
- W2078771950 hasVolume "131" @default.
- W2078771950 isParatext "false" @default.
- W2078771950 isRetracted "false" @default.
- W2078771950 magId "2078771950" @default.
- W2078771950 workType "article" @default.