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- W2078775090 abstract "A recent paper by J. R. St-Jean and colleagues reported the complete genome sequences of the human coronavirus OC43 (HCoV-OC43) laboratory strain from the American Type Culture Collection (ATCC) and an HCoV-OC43 clinical isolate, designated Paris (7). The ATCC HCoV-OC43 (VR759) strain originated in 1967 and was passaged several times in suckling mouse brain and in cell culture. The contemporary HCoV-OC43 Paris strain was isolated in 2001 and was subsequently cultured in an HRT-18 cell line by the authors. A high degree of genetic stability was stated for HCoV-OC43 since only six nucleotide variations in the whole genome could be observed between both HCoV-OC43 strains, with isolation dates 34 years apart. There are, however, some arguments to suggest that the HCoV-OC43 genome is not as stable as suggested by the authors and that the HCoV-OC43 Paris strain might not be a contemporary strain but might be a result of cross-contamination with the ATCC HCoV-OC43 strain." @default.
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- W2078775090 date "2005-03-01" @default.
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- W2078775090 title "Genetic Variability of Human Respiratory Coronavirus OC43" @default.
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- W2078775090 doi "https://doi.org/10.1128/jvi.79.5.3223-3225.2005" @default.
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