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• W2078775150 abstract "In Brief Purpose: To evaluate the onset and duration of improvement in best-corrected visual acuity (BCVA) in eyes treated with dexamethasone intravitreal implant 0.7 mg (DEX implant) for macular edema after branch or central retinal vein occlusion. Methods: Post hoc analysis of data from 2 previously reported multicenter, 6-month, randomized sham-controlled clinical trials. Patients received a single DEX implant (n = 427) or sham procedure (n = 426) in the study eye. The primary endpoint was the percentage of eyes with ≥15-letter improvement in BCVA from baseline at postimplant Day 7. Results: The baseline mean BCVA was 20/80. At Day 7, 10.3% of DEX implant–treated eyes versus 4.0% of sham-treated eyes (P < 0.001) had ≥15-letter improvement in the BCVA, and 27.2% of DEX implant–treated eyes versus 10.6% of sham-treated eyes had ≥10-letter improvement (P < 0.001). The mean improvement at Day 7 was 5.3 letters (branch retinal vein occlusion, 5.1; and central retinal vein occlusion, 5.8) with DEX implant and 1.6 letters (branch retinal vein occlusion, 2.3; and central retinal vein occlusion, 0.1) with sham (P < 0.001). The mean time from initial observation of ≥15-letter BCVA gain to the last observation of ≥15-letter BCVA gain was 70 days. Conclusion: Dexamethasone intravitreal implant treatment led to improvement in BCVA compared with sham procedure as early as postimplant Day 7. The duration of ≥3-line improvement was typically 2 to 3 months. In a randomized sham-controlled clinical trial evaluating dexamethasone intravitreal implant for the treatment of macular edema after retinal vein occlusion, improvement in the best-corrected visual acuity compared with sham procedure was seen as early as 7 days after the implant, with gains of ≥3 lines typically sustained for 2 months to 3 months." @default.
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• W2078775150 date "2014-09-01" @default.
• W2078775150 modified "2023-09-25" @default.
• W2078775150 title "ONSET AND DURATION OF VISUAL ACUITY IMPROVEMENT AFTER DEXAMETHASONE INTRAVITREAL IMPLANT IN EYES WITH MACULAR EDEMA DUE TO RETINAL VEIN OCCLUSION" @default.
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• W2078775150 doi "https://doi.org/10.1097/iae.0000000000000167" @default.
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