FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078776138> ?p ?o ?g. }

• W2078776138 endingPage "52" @default.
• W2078776138 startingPage "42" @default.
• W2078776138 abstract "HIV-1 Tat causes extensive neuroinflammation that may progress to AIDS-related encephalitis and dementia. Celastrol possesses various biological activities such as anti-oxidant, anti-tumor, and anti-inflammatory activities. In this study, we investigated the modulatory effects of celastrol on HIV-1 Tat-induced inflammatory responses and the molecular mechanisms underlying its action in astrocytes. Pre-treatment of CRT-MG human astroglioma cells with celastrol significantly inhibited HIV-1 Tat-induced expression of ICAM-1/VCAM-1 and subsequent monocyte adhesiveness in CRT-MG cells. In addition, celastrol suppressed HIV-1 Tat-induced expression of pro-inflammatory chemokines, such as CXCL10, IL-8, and MCP-1. Celastrol decreased HIV-1 Tat-induced activation of JNK MAPK, AP-1, and NF-κB. Furthermore, celastrol induced mRNA and protein expression of HO-1 as well as Nrf2 activation. Blockage of HO-1 expression using siRNA reversed the inhibitory effect of celastrol on HIV-1 Tat-induced inflammatory responses. These results suggest that celastrol has regulatory effects on HIV-1 Tat-induced inflammatory responses by blocking the JNK MAPK-AP-1/NF-κB signaling pathways and inducing HO-1 expression in astrocytes." @default.
• W2078776138 created "2016-06-24" @default.
• W2078776138 creator A5018983272 @default.
• W2078776138 creator A5030458449 @default.
• W2078776138 creator A5041813523 @default.
• W2078776138 creator A5053765314 @default.
• W2078776138 creator A5070173208 @default.
• W2078776138 creator A5078229156 @default.
• W2078776138 creator A5080127932 @default.
• W2078776138 date "2014-10-01" @default.
• W2078776138 modified "2023-09-30" @default.
• W2078776138 title "Celastrol ameliorates HIV-1 Tat-induced inflammatory responses via NF-kappaB and AP-1 inhibition and heme oxygenase-1 induction in astrocytes" @default.
• W2078776138 cites W1530364137 @default.
• W2078776138 cites W1583492957 @default.
• W2078776138 cites W1600224209 @default.
• W2078776138 cites W1789490659 @default.
• W2078776138 cites W1870780415 @default.
• W2078776138 cites W1905628010 @default.
• W2078776138 cites W1965059673 @default.
• W2078776138 cites W1967291007 @default.
• W2078776138 cites W1974682598 @default.
• W2078776138 cites W1974835419 @default.
• W2078776138 cites W1985057198 @default.
• W2078776138 cites W1988963406 @default.
• W2078776138 cites W1989476041 @default.
• W2078776138 cites W1991504591 @default.
• W2078776138 cites W1991968280 @default.
• W2078776138 cites W1994774985 @default.
• W2078776138 cites W1995625289 @default.
• W2078776138 cites W2002096100 @default.
• W2078776138 cites W2005904261 @default.
• W2078776138 cites W2009905886 @default.
• W2078776138 cites W2010358244 @default.
• W2078776138 cites W2027580727 @default.
• W2078776138 cites W2037057064 @default.
• W2078776138 cites W2037390262 @default.
• W2078776138 cites W2043849781 @default.
• W2078776138 cites W2044168327 @default.
• W2078776138 cites W2044177663 @default.
• W2078776138 cites W2046457366 @default.
• W2078776138 cites W2053793074 @default.
• W2078776138 cites W2060662813 @default.
• W2078776138 cites W2061150581 @default.
• W2078776138 cites W2062868705 @default.
• W2078776138 cites W2063060213 @default.
• W2078776138 cites W2065752062 @default.
• W2078776138 cites W2067592236 @default.
• W2078776138 cites W2099080968 @default.
• W2078776138 cites W2102057694 @default.
• W2078776138 cites W2129139418 @default.
• W2078776138 cites W2138246067 @default.
• W2078776138 cites W2139258120 @default.
• W2078776138 cites W2144637482 @default.
• W2078776138 cites W2152180560 @default.
• W2078776138 cites W2161579926 @default.
• W2078776138 cites W2164572353 @default.
• W2078776138 cites W2165626477 @default.
• W2078776138 cites W2168999576 @default.
• W2078776138 cites W2169241566 @default.
• W2078776138 doi "https://doi.org/10.1016/j.taap.2014.07.010" @default.
• W2078776138 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25064159" @default.
• W2078776138 hasPublicationYear "2014" @default.
• W2078776138 type Work @default.
• W2078776138 sameAs 2078776138 @default.
• W2078776138 citedByCount "45" @default.
• W2078776138 countsByYear W20787761382014 @default.
• W2078776138 countsByYear W20787761382015 @default.
• W2078776138 countsByYear W20787761382016 @default.
• W2078776138 countsByYear W20787761382017 @default.
• W2078776138 countsByYear W20787761382018 @default.
• W2078776138 countsByYear W20787761382019 @default.
• W2078776138 countsByYear W20787761382020 @default.
• W2078776138 countsByYear W20787761382021 @default.
• W2078776138 countsByYear W20787761382022 @default.
• W2078776138 countsByYear W20787761382023 @default.
• W2078776138 crossrefType "journal-article" @default.
• W2078776138 hasAuthorship W2078776138A5018983272 @default.
• W2078776138 hasAuthorship W2078776138A5030458449 @default.
• W2078776138 hasAuthorship W2078776138A5041813523 @default.
• W2078776138 hasAuthorship W2078776138A5053765314 @default.
• W2078776138 hasAuthorship W2078776138A5070173208 @default.
• W2078776138 hasAuthorship W2078776138A5078229156 @default.
• W2078776138 hasAuthorship W2078776138A5080127932 @default.
• W2078776138 hasConcept C13373296 @default.
• W2078776138 hasConcept C17991360 @default.
• W2078776138 hasConcept C181199279 @default.
• W2078776138 hasConcept C185592680 @default.
• W2078776138 hasConcept C190283241 @default.
• W2078776138 hasConcept C203014093 @default.
• W2078776138 hasConcept C2776217839 @default.
• W2078776138 hasConcept C2776914184 @default.
• W2078776138 hasConcept C2777228702 @default.
• W2078776138 hasConcept C2777730290 @default.
• W2078776138 hasConcept C2779219270 @default.
• W2078776138 hasConcept C2781184567 @default.
• W2078776138 hasConcept C502942594 @default.
• W2078776138 hasConcept C55493867 @default.
• W2078776138 hasConcept C57074206 @default.

• next