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• W2078779797 abstract "Our previous study demonstrated that fibronectin (FN) is a negative regulator of Porphyromonas gingivalis fimbria-induced pathogenesis in the initiation and development of chronic periodontal diseases. We show herein the regulatory action of interleukin-6 (IL-6) on FN expression in fimbria-treated human gingival fibroblasts. Interestingly, the decrease in FN expression in the cells treated with fimbriae at a high dose (8 microg of protein ml(-1)) was negated by treatment with anti-IL-6 antibody. Also, the increase in FN expression in cells treated with fimbriae at a low dose (1 microg of protein ml(-1)) was inhibited by exogenous IL-6. These results suggest that P. gingivalis fimbria-stimulated FN expression in human gingival fibroblasts is negatively regulated by endogenous IL-6." @default.
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• W2078779797 date "2005-02-01" @default.
• W2078779797 modified "2023-10-18" @default.
• W2078779797 title "Interleukin-6 negatively regulatesPorphyromonas gingivalisfimbria-stimulated fibronectin expression in human gingival fibroblasts" @default.
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• W2078779797 doi "https://doi.org/10.1016/j.femsim.2004.08.003" @default.
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