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- W2078781736 abstract "The Focus article by Doctors Sove and Light calls attention to the generally neglected inner vation of nerve sheaths, the nervi nervorum. It is asserted that the hypotheses that were pro posed during the last century concerning the diagnosis and treatment of neuropathic and musculoskeletal pain have failed to withstand scientific scrutiny and that the nervi nervorum may be at least one of the offending agents that cause neuropathic pain. The Focus article gives a historical review of what is known about the nervi nervorum (including in this cate gory the nervi vasorum nervorum , the nerve fibers that supply the blood vessels within the nerve sheath). They are chiefly unmyelinated axons havinq free endings (although some have encapsulated endings) in the lay ers of connective tissue about peripheral nerves [13], and many of these axons contain neuropeptides, such as substance P (SP) and calcitonin gene-related peptide (CGRP) [2,6]. The authors have recently shown that at least some nervi nervorum in the deep paraspinal tis sues are nociceptors [7]. The nervi nervorum afferents have multiple, punctate receptive fields and respond to noxious mechanical, chemical , and thermal stimuli. Interestingly, they can also have receptive fields in adja cent muscles or tendons. The authors agree with Asbury and Fields [3] that the nervi nervorum contribute to nerve trunk pain. Damage to a peripheral nerve or application of cap saicin results in hyperemia as a result of the release of SP and CGRP from the nervi nervorum [26,27]. The hyperemia can be prevented by local administration of a" @default.
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- W2078781736 date "1997-09-01" @default.
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- W2078781736 title "An alternative mechanism for neuropathic pain" @default.
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- W2078781736 doi "https://doi.org/10.1016/s1082-3174(97)70031-x" @default.
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