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- W2078785991 endingPage "349" @default.
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- W2078785991 abstract "Applications of pharmacogenetics in children with attention-deficit/hyperactivity disorder Florence Levy School of Psychiatry, University of New South Wales and Prince of Wales Hospital, Sydney, Australia Abstract: This review examines molecular genetic studies shown to be of importance in the etiology of attention-deficit/hyperactivity disorder (ADHD) and contrasts prefrontal versus subcortical mechanisms. Although these mechanisms are not completely dissociated, an understanding of prefrontal dopaminergic/noradrenergic versus subcortical D1/D2 receptor mechanisms is useful for studies of diagnosis versus potential adverse effects. Dopamine physiology, dopamine receptor studies, alpha-2 agonist studies, and dopamine transporter and potential new therapies are reviewed. Further understandings of molecular mechanisms involved in etiology versus treatment and adverse effects should help personalize the treatment of ADHD. Keywords: ADHD, dopamine transporter, dopamine receptors, alpha-2 agonists, COMT, stimulant side effects" @default.
- W2078785991 created "2016-06-24" @default.
- W2078785991 creator A5035803678 @default.
- W2078785991 date "2014-11-01" @default.
- W2078785991 modified "2023-10-18" @default.
- W2078785991 title "Applications of pharmacogenetics in children with attention-deficit/hyperactivity disorder" @default.
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- W2078785991 doi "https://doi.org/10.2147/pgpm.s52844" @default.
- W2078785991 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4230702" @default.
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- W2078785991 hasPublicationYear "2014" @default.
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