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- W2078787351 abstract "Colorectal cancer (CRC) is the third most common cause of cancer-related deaths with treatment of advanced and metastatic CRC (mCRC) remaining palliative at best. (1) The epidermal growth factor receptor (EGFR) has been identified as a therapeutic target for a multitude of malignancies, including mCRC. Ligand-binding to EGFR results in the subsequent activation of multiple signal transduction pathways including the PI3K/AKT and RAS/RAF/MAPK pathways, which are vital for cell growth and survival. (2) Constitutive activation of these signaling pathways leads to deregulated cellular proliferation, malignant progression, and invasion. (3.)" @default.
- W2078787351 created "2016-06-24" @default.
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- W2078787351 date "2014-01-14" @default.
- W2078787351 modified "2023-09-26" @default.
- W2078787351 title "When to screen and not to screen" @default.
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- W2078787351 doi "https://doi.org/10.4161/cbt.27741" @default.
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