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- W2078790899 abstract "Background Deletions of the long arm of chromosome 11 are frequently identified in human neuroblastomas. Procedure We screened 394 primary neuroblastomas and 52 tumor-derived cell lines with a panel of 11q and 11p polymorphic markers to determine the frequency of chromosome 11 allelic deletion, and to differentiate partial deletions of chromosome 11q (unb[11q] LOH) from whole chromosome loss. Results Allelic deletion occurred most frequently at cytogenetic band 11q23 and was detected in 161 primary neuroblastomas (41%) and 18 cell lines (35%). Eighty-seven tumors (22%) had unb[11q] LOH with a heterogeneous distribution of deletion breakpoints. Unb[11q] LOH was highly correlated with age > 1 year at diagnosis (P = 0.008), stage 4 disease (P = 0.001), unfavorable Shimada histopathology (P < 0.001), and assignment to a high-risk therapeutic protocol (P < 0.001), and was inversely correlated with MYCN amplification (P = 0.018). Patients whose tumors showed unb[11q] LOH were less likely to survive (P < 0.001), but there was only a trend towards an independent prognostic influence in multivariate analyses. Conclusions Thus, structural rearrangements resulting in unb[11q] LOH commonly occur during the malignant evolution of high-risk neuroblastomas with single-copy MYCN. Med. Pediatr. Oncol. 35: 544–546, 2000. © 2000 Wiley-Liss, Inc." @default.
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- W2078790899 date "2000-01-01" @default.
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- W2078790899 title "Deletion of 11q23 is a frequent event in the evolution ofMYCN single-copy high-risk neuroblastomas" @default.
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- W2078790899 doi "https://doi.org/10.1002/1096-911x(20001201)35:6<544::aid-mpo10>3.0.co;2-2" @default.
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