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- W2078791569 abstract "This report describes the effect of chronic estradiol treatment on the serotonin transporter in the female rat brain. Both [3H]imipramine binding and [3H]serotonin uptake increased by 20-30% in the frontal cortex and hypothalamus of ovariectomized rats after 12 days of 17 beta-estradiol treatment. No differences were observed in the binding and uptake parameters as a function of the rats' estrous cycle or in untreated ovariectomized rats, as compared to controls. Estradiol in vitro, inhibits [3H]imipramine binding as well as serotonin uptake in rat brain and human platelets. Like serotonin, estradiol decreases the dissociation rate in vitro of [3H]imipramine from its binding site in a dose-dependent manner." @default.
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- W2078791569 date "1987-04-01" @default.
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- W2078791569 title "Upregulation of imipramine binding and serotonin uptake by estradiol in female rat brain" @default.
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- W2078791569 doi "https://doi.org/10.1016/s0006-8993(87)80034-3" @default.
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